Meningococcal vaccines : methods and protocols /

Meningococcal vaccines : methods and protocols / edited by Andrew J. Pollard and Martin C.J. Maiden ; foreword by E. Richardson Moxon. - Totowa, N.J. : Humana Press, ©2001. - 1 online resource (xvii, 421 pages) : illustrations - Methods in molecular medicine ; 66 . - Methods in molecular medicine ; 66. .

Companion volume to: Meningococal disease.

Includes bibliographical references and index.

Meningococcal vaccines and vaccine developments / I.M. Feavers -- Immune response and host-pathogen interactions / A.J. Pollard and D. Goldblatt -- Purification of capsular polysaccharide / Q. Yang and H. Jennings -- Protein-polysaccharide conjugation / Z. Guo and H. Jennings -- N -propionylation / Z. Guo and H. Jennings -- Outer membrane protein purification / C. Arigita [and others] -- Outer membrane protein vesicle vaccines for meningococcal disease / C.E. Frasch [and others] -- Methods for manipulation of transferrin-binding proteins / L.M. DeWinter and A.B. Schryvers -- Methods for the preparation and crystallization of fab fragments in complex with peptide antigens derived from N. Meningitidis outer membrane proteins / R.F. Collins and J.P. Derrick -- Application of optical biosensor techniques to the characterization of porA-antibody binding kinetics / J. Suker and B.M. Charalambous -- Construction of porA mutants / P. Ley and L. Alphen -- Construction of LPS mutants / P. Ley and L. Steeghs -- Recombinant proteins in vaccine development / M. Christodoulides, K.A. Jolley and J.E. Heckels -- Identification of peptides that mimic N. Meningitidis LOS epitopes via the use of combinatorial phage-display libraries / P.J. Brett, I.M. Feavers and B.M. Charalambous -- Testing meningococcal vaccines for mitogenicity and superantigenicity / A.A. Delvig, J.H. Robinson and L. Wetzler -- Early experiences with nasal vaccines against meningococcal disease / J. Holst and B. Haneberg -- Animal models for meningococcal disease / A.R. Gorringe [and others] -- Determination of antibody responses to meningococcal antigens by ELISA / E. Rosenqvist, H. Käyhty and A.J. Pollard -- Immunoblot analysis of sera from patients and vaccinees / E. Wedege -- Serogroup B and C serum bactericidal assays / R. Borrow and G.M. Carlone -- A modified ELISA for measurement of high-avidity IgG antibodies to meningococcal serogroup c polysaccharide that correlate with bactericidal titers / D.M. Granoff and J.J. Donnelly -- Whole-blood model / C.A. Ison -- Antibody-induced opsonophagocytosis of serogroup b meningococci measured by flow cytometry / T.E. Michaelsen and A. Aase -- T-cell responses against meningococcal antigens / L.M. Næss [and others] -- CF4 T-cell epitope mapping / A.A. Delvig and J.H. Robinson -- Epitope mapping / J.E. Heckels and M. Christodoulides -- Meningococcal vaccine trials / P. Farrington and E. Miller -- The introduction of group C conjugate meningococcal vaccine into the UK / D.M. Salisbury.

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The development of a comprehensive vaccine against Neisseria meningitidis, the causative agent of meningococcal disease, has remained elusive because of bacterial diversity and immunologic evasion. In Meningococcal Vaccines: Methods and Protocols, Andrew Pollard and Martin Maiden have assembled an impressive collection of the latest molecular and cellular techniques for the development, evaluation, and implementation of vaccines to be used against this dreaded disease. The contributors-leading scientists, clinicians, and public health physicians-describe in detail the many approaches to vaccine design, as well as the assessment of immune response to vaccine candidates and novel vaccine formulations. They also present as a test case the recent implementation of a new meningococcal vaccine in the United Kingdom. A companion volume, Meningococcal Disease: Methods and Protocols, contains detailed methods for diagnostic microbiology, bacterial characterization, epidemiology, host-pathogen interactions, and clinical studies. Timely and comprehensive, Meningococcal Vaccines: Methods and Protocols provides the scientist, public health physician, epidemiologist, clinical microbiologist, and clinician with the essential tools to lay bare the secrets of the meningococcus and to develop, evaluate, and implement successful new meningococcal vaccines.

Electronic reproduction.
[Place of publication not identified] :
HathiTrust Digital Library,

Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.


0896038017 9780896038011 9781592591480 1592591485 1280821132 9781280821134 9786610821136 6610821135

10.1385/1592591485. doi

Bacterial vaccines--Laboratory manuals.
Neisseria meningitidis--Laboratory manuals.
Meningitis--Laboratory manuals.
Meningococcal Vaccines
Meningitis, Meningococcal
Drug Therapy
Bacterial Vaccines
Meningococcal Infections
Meningitis, Bacterial
Central Nervous System Bacterial Infections
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Neisseriaceae Infections
Gram-Negative Bacterial Infections
Biological Products
Central Nervous System Infections
Bacterial Infections
Complex Mixtures
Bacterial Infections and Mycoses
Central Nervous System Diseases
Chemicals and Drugs
Nervous System Diseases
Vaccins antibactériens--Manuels de laboratoire.
Neisseria meningitidis--Manuels de laboratoire.
Méningite--Manuels de laboratoire.
HEALTH & FITNESS--Diseases--Nervous System (incl. Brain)
Bacterial vaccines.
Neisseria meningitidis.
Wetenschappelijke technieken.
Meningitis cerebrospinalis epidemica

Electronic books.
Laboratory manuals.

QR189.5.B33 / M46 2001


WC 245 / M5457 2001

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