Methionine dependence of cancer and aging : methods and protocols / edited by Robert M. Hoffman. - 1 online resource (xii, 329 pages) : illustrations (some color) - Methods in molecular biology, volume 1866 1940-6029 ; . - Methods in molecular biology (Clifton, N.J.) ; v. 1866. .

Includes bibliographical references and index.

Methods to study the role of methionine-restricted diet and methioninase in cancer growth control / Altered methionine metabolism in cancer cells / Linkage of methionine dependence and other features of malignancy / Isolation and characterization of methionine-independent clones from methionine-dependent cancer cells / Tumor-specific S/G2-phase cell cycle arrest of cancer cells by methionine restriction / Preclinical breast cancer models to investigate metabolic priming by methionine restriction / Efficacy of methionine-restricted diets on cancers in vivo / Dietary methionine restriction-based cancer chemotherapy in rodents / Clinical studies of methionine-restricted diets for cancer patients / Development of recombinant methioninase for cancer treatment / Methioninase cell-cycle trap cancer chemotherapy / High efficacy of recombinant methioninase on patient-derived orthotopic xenograft (PDOX) mouse models of cancer / Total methionine restriction treatment of cancer / Methioninase gene therapy / Selenomethionine and methioninase : selenium free radical anticancer activity / Safety and toxicity of recombinant methioninase and polyethylene glycol (PEG) recombinant methioninase in primates / Pilot phase I clinical trial of methioninase on high-stage cancer patients : rapid depletion of circulating methionine / Methionine gamma lyase from Clostridium sporogenes increases the anticancer efficacy of doxorubicin on A549 cancer cells in vitro and human cancer xenografts / Methionine restriction and life-span extension / L-[Methyl-11C] methionine-positron-emission tomography (MET-PET) / Is the Hoffman effect for methionine overuse analogous to the warburg effect for glucose overuse in cancer? / Recombinant methioninase as a DNA demethylation agent / Homocysteine, thioretinaco ozonide, and oxidative phosphorylation in cancer and aging : a proposed clinical trial protocol / Afterword : oral methioninase--answer to cancer and fountain of youth? / Epilogue : why do we keep mis-targeting cancer chemotherapy when the methionine target has been obvious for more than a half-century? Shushma Chaturvedi and Joseph R. Bertino -- Robert M. Hoffman, Peter H. Stern, DennisW. Coalson, C. DouglasWallace, and Richard W. Erbe -- Robert M. Hoffman and Richard W. Erbe -- Stacey L. Borrego, Da-Wei Lin, and Peter Kaiser -- Robert M. Hoffman and Shuya Yano -- Elena Strekalova, Dmitry Malin, Harisha Rajanala, and Vincent L. Cryns -- Robert M. Hoffman, Yasunori Hoshiya, and Weiyan Guo -- Robert M. Hoffman and Peter H. Stern -- Robert M. Hoffman -- Robert M. Hoffman, Yuying Tan, Shukuan Li, Qinghong Han, Shigeo Yagi, Tomoaki Takakura, Akio Takimoto, Kenji Inagaki, and Daizou Kudou -- Robert M. Hoffman, Shuya Yano, and Kentaro Igarashi -- Robert M. Hoffman, Takashi Murakami, Kei Kawaguchi, Kentaro Igarashi, Yuying Tan, Shukuan Li, and Qinghong Han -- Robert M. Hoffman, Demetrius M. Kokkinakis, and Eugene P. Frenkel -- Robert M. Hoffman, Kenji Miki, Waddah Al-Refaie, Mingxu Xu, and Yuying Tan -- Julian E. Spallholz -- Robert M. Hoffman, Zhijian Yang, Yuying Tan, Qinghong Han, Shukuan Li, and Shigeo Yagi -- Robert M. Hoffman, Yuying Tan, Shukuan Li, Qinghong Han, Jorge Zavala Sr, and Jorge Zavala Jr -- V.S. Pokrovsky, N. Yu. Anisimova, D. Zh. Davydov, S.V. Bazhenov, N.V. Bulushova, G.B. Zavilgelsky, V.Y. Kotova, and I.V. Manukhov -- Robert M. Hoffman -- Robert M. Hoffman -- Robert M. Hoffman -- Robert M. Hoffman and David Machover -- Kilmer S. McCully -- Robert M. Hoffman, Qinghong Han, Kei Kawaguchi, Shukuan Li, and Yuying Tan --

9781493987962 1493987968

com.springer.onix.9781493987962 Springer Nature

GBB957660 bnb

019249652 Uk


Methionine.
Cancer--Molecular aspects.
Cancer--Chemotherapy.
Methionine.
Neoplasms--metabolism.
Aging.
Cancer--Chemotherapy.
Cancer--Molecular aspects.
Methionine.


Laboratory Manual.
Electronic books.

QP562.M4 / M48 2019

572/.65

QU 60

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