Active properties of hippocampal CA3 pyramidal neuron dendrites (Record no. 340550)

000 -LEADER
fixed length control field 02193ntm a22002897a 4500
003 - CONTROL NUMBER IDENTIFIER
control field AT-ISTA
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20190813091742.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 160531s2012 au ||||| m||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Transcribing agency IST
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Kim, Sooyun
9 (RLIN) 2636
245 ## - TITLE STATEMENT
Title Active properties of hippocampal CA3 pyramidal neuron dendrites
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Name of publisher, distributor, etc. IST Austria
Date of publication, distribution, etc. 2012
500 ## - GENERAL NOTE
General note Thesis
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Formatted contents note Publication List
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Formatted contents note Abstract
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Formatted contents note 1 Introduction
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Formatted contents note 2 Materials and Methods
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Formatted contents note 3 Results
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Formatted contents note 4 Discussion
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Formatted contents note 5 List of Abbreviations
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Formatted contents note 6 References
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Formatted contents note 7 Curriculum Vitae
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Formatted contents note 8 Acknowledgments
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Formatted contents note 9 Appendix
520 ## - SUMMARY, ETC.
Summary, etc. CA3 pyramidal neurons are important for memory formation and pattern completion in the hippocampal network. These neurons receive multiple excitatory inputs from numerous sources. Therefore, the rules of spatiotemporal integration of multiple synaptic inputs and propagation of action potentials are important to understand how CA3 neurons contribute to higher brain functions at cellular level. By using confocally targeted patch-clamp recording techniques, we investigated the biophysical properties of rat CA3 pyramidal neuron dendrites. We found two distinct dendritic domains critical for action potential initiation and propagation: In the proximal domain, action potentials initiated in the axon backpropagate actively with large amplitude and fast time course. In the distal domain, Na+-channel mediated dendritic spikes are efficiently evoked by local dendritic depolarization or waveforms mimicking synaptic events. These findings can be explained by a high Na+-to-K+ conductance density ratio of CA3 pyramidal neuron dendrites. The results challenge the prevailing view that proximal mossy fiber inputs activate CA3 pyramidal neurons more efficiently than distal perforant inputs by showing that the distal synapses trigger a different form of activity represented by dendritic spikes. The high probability of dendritic spike initiation in the distal area may enhance the computational power of CA3 pyramidal neurons in the hippocampal network.
942 ## - ADDED ENTRY ELEMENTS (KOHA)
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  Not Lost       Library Library 2016-05-31 AT-ISTA#001146 2018-11-06 2016-05-31 Book

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