Cell adhesion and cell fate: An effective feedback loop during zebrafish gastrulation (Record no. 358241)

000 -LEADER
fixed length control field 02454ntm a22002897a 4500
003 - CONTROL NUMBER IDENTIFIER
control field AT-ISTA
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20190813101658.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 170612s2017 au ||||| m||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Transcribing agency IST
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Barone, Vanessa
9 (RLIN) 3358
245 ## - TITLE STATEMENT
Title Cell adhesion and cell fate: An effective feedback loop during zebrafish gastrulation
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Name of publisher, distributor, etc. IST Austria
Date of publication, distribution, etc. 2017
500 ## - GENERAL NOTE
General note Thesis
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Formatted contents note Abstract
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Formatted contents note Acknowledgments
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Formatted contents note List of Figures
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Formatted contents note List of Symbols/Abbreviations
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Formatted contents note 1 Introduction
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Formatted contents note 2 Materials and methods
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Formatted contents note 3 Results
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Formatted contents note 4 Discussion
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Formatted contents note References
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Formatted contents note A. Appendix 1
520 ## - SUMMARY, ETC.
Summary, etc. Cell-cell contact formation constitutes the first step in the emergence of multicellularity in evolution, thereby allowing the differentiation of specialized cell types. In metazoan development, cell-cell contact formation is thought to influence cell fate specification, and cell fate specification has been implicated in cell-cell contact formation. However, remarkably little is yet known about whether and how the interaction and feedback between cell-cell contact formation and cell fate specification affect development. Here we identify a positive feedback loop between cell-cell contact duration, morphogen signaling and mesendoderm cell fate specification during zebrafish gastrulation. We show that long lasting cell-cell contacts enhance the competence of prechordal plate (ppl) progenitor cells to respond to Nodal signaling, required for proper ppl cell fate specification. We further show that Nodal signalling romotes ppl cell-cell contact duration, thereby generating an effective positive feedback loop between ppl cell-cell contact duration and cell fate specification. Finally, by using a combination of theoretical modeling and experimentation, we show that this feedback loop determines whether anterior axial mesendoderm cells become ppl progenitors or, instead, turn into endoderm progenitors. Our findings reveal that the gene regulatory networks leading to cell fate diversification within the developing embryo are controlled by the interdependent activities of cell-cell signaling and contact formation.
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://doi.org/10.15479/AT:ISTA:th_825">https://doi.org/10.15479/AT:ISTA:th_825</a>
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Permanent Location Current Location Date acquired Barcode Date last seen Price effective from Koha item type
  Not Lost       Library Library 2017-06-12 AT-iSTA#001357 2018-11-06 2017-06-12 Book

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