Bacterial herd and social immunity to phages (Record no. 358242)

000 -LEADER
fixed length control field 02563ntm a22002897a 4500
003 - CONTROL NUMBER IDENTIFIER
control field AT-ISTA
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20190813093421.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 170612s2017 au ||||| m||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Transcribing agency IST
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Payne, Pavel
9 (RLIN) 3359
245 ## - TITLE STATEMENT
Title Bacterial herd and social immunity to phages
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Name of publisher, distributor, etc. IST Austria
Date of publication, distribution, etc. 2017
500 ## - GENERAL NOTE
General note Thesis
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Formatted contents note Biographical Sketch
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Formatted contents note List of Publications
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Formatted contents note Acknowledgments
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Formatted contents note Abstract
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Formatted contents note List of Tables
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Formatted contents note List of Figures
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Formatted contents note List of Abbreviations
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Formatted contents note 1 Introduction
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Formatted contents note 2 CRISPR-based herd immunity limits phage epidemics in bacterial populations
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Formatted contents note 3 Pheromone mediated bacterial social immunity
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Formatted contents note 4 Conlcusions
520 ## - SUMMARY, ETC.
Summary, etc. Bacteria and their pathogens – phages – are the most abundant living entities on Earth. Throughout their coevolution, bacteria have evolved multiple immune systems to overcome the ubiquitous threat from the phages. Although the molecu- lar details of these immune systems’ functions are relatively well understood, their epidemiological consequences for the phage-bacterial communities have been largely neglected. In this thesis we employed both experimental and theoretical methods to explore whether herd and social immunity may arise in bacterial popu- lations. Using our experimental system consisting of Escherichia coli strains with a CRISPR based immunity to the T7 phage we show that herd immunity arises in phage-bacterial communities and that it is accentuated when the populations are spatially structured. By fitting a mathematical model, we inferred expressions for the herd immunity threshold and the velocity of spread of a phage epidemic in partially resistant bacterial populations, which both depend on the bacterial growth rate, phage burst size and phage latent period. We also investigated the poten- tial for social immunity in Streptococcus thermophilus and its phage 2972 using a bioinformatic analysis of potentially coding short open reading frames with a signalling signature, encoded within the CRISPR associated genes. Subsequently, we tested one identified potentially signalling peptide and found that its addition to a phage-challenged culture increases probability of survival of bacteria two fold, although the results were only marginally significant. Together, these results demonstrate that the ubiquitous arms races between bacteria and phages have further consequences at the level of the population.
942 ## - ADDED ENTRY ELEMENTS (KOHA)
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Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Permanent Location Current Location Date acquired Barcode Date last seen Price effective from Koha item type
  Not Lost       Library Library 2017-06-12 AT-ISTA#001358 2018-11-06 2017-06-12 Book

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