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04939nam a22005535i 4500 |
| 001 - CONTROL NUMBER |
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978-1-4614-8301-4 |
| 003 - CONTROL NUMBER IDENTIFIER |
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DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20180115171531.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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cr nn 008mamaa |
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131115s2014 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9781461483014 |
| -- |
978-1-4614-8301-4 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/978-1-4614-8301-4 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
QH323.5 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
PBW |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MAT003000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
570.285 |
| Edition number |
23 |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Komarova, Natalia L. |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
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| Title |
Targeted Cancer Treatment in Silico |
| Medium |
[electronic resource] : |
| Remainder of title |
Small Molecule Inhibitors and Oncolytic Viruses / |
| Statement of responsibility, etc. |
by Natalia L. Komarova, Dominik Wodarz. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
New York, NY : |
| Name of producer, publisher, distributor, manufacturer |
Springer New York : |
| -- |
Imprint: Birkhäuser, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2014. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
XV, 227 p. 71 illus., 26 illus. in color. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
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| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 490 1# - SERIES STATEMENT |
|---|
| Series statement |
Modeling and Simulation in Science, Engineering and Technology, |
| International Standard Serial Number |
2164-3679 |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Background and Scope of the Book -- Part I Treatment of Cancer with Small Molecule Inhibitors -- An Introduction to Small Molecule Inhibitors and Chronic Myeloid Leukemia -- Basic Dynamics of Chronic Myeloid Leukemia During Imatinib Treatment -- Stochastic Modeling of Cellular Growth, Treatment, and Resistance Generation -- Evolutionary Dynamics of Drug Resistant Mutants in Targeted Treatment of CML -- Effect of Cellular Quiescence on the Evolution of Drug Resistance in CML -- Combination Therapies: Short term versus Long term Strategies -- Cross Resistance: Treatment and Modeling -- Mathematical Modeling of Cyclic Cancer Treatments -- Part II Treatment of Cancer with Oncolytic Viruses -- Introduction to Oncolytic Viruses -- Basic Dynamics of Oncolytic Viruses -- Mitotic Virus Transmission and Immune Responses -- Axiomatic Approaches to Oncolytic Virus Modeling -- Spatial Oncolytic Virus Dynamics -- Oncolytic Viruses and the Eradication of Drug-resistant Tumor Cells. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
This monograph provides the first in-depth study of how mathematical and computational approaches can be used to advance our understanding of cancer therapies and to improve treatment design and outcome. Over the past century, the search for a cancer cure has been a primary occupation of medical researchers. So far, it has led to a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, and most recently, small molecule inhibitors and oncolytic viruses. Each treatment tends to have a certain effectiveness in a specific class of patients, but it is often unclear what exactly causes it to succeed or fail. Recent technological advances have given rise to an ever increasing pool of data and information that highlight the complexity underlying the cancers and their response to treatment. Next to experimental and clinical research, mathematical and computational approaches are becoming an indispensible tool to understand this complexity. Targeted Cancer Treatment in Silico is organized into two parts, corresponding to two types of targeted cancer treatment: small molecule inhibitors and oncolytic viruses. In each part, the authors provide a brief overview of the treatment’s biological basis and present the mathematical methods most suitable for modeling it. Additionally, they discuss how these methods can be applied to answer relevant questions about treatment mechanisms and propose modifications to treatment approaches that may potentially increase success rates. The book is intended for both the applied mathematics and experimental oncology communities, as mathematical models are becoming an increasingly important supplement to laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, it will be a valuable resource for scientists and graduate students alike, and can also serve as an upper-division undergraduate or graduate textbook. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Mathematics. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Cancer research. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Oncology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Applied mathematics. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Engineering mathematics. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Biomathematics. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Mathematics. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Physiological, Cellular and Medical Topics. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Cancer Research. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Mathematical and Computational Biology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Oncology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Genetics and Population Dynamics. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Applications of Mathematics. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Wodarz, Dominik. |
| Relator term |
author. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
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| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Printed edition: |
| International Standard Book Number |
9781461483007 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
|---|
| Uniform title |
Modeling and Simulation in Science, Engineering and Technology, |
| International Standard Serial Number |
2164-3679 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
<a href="http://dx.doi.org/10.1007/978-1-4614-8301-4">http://dx.doi.org/10.1007/978-1-4614-8301-4</a> |
| 912 ## - |
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ZDB-2-SMA |