Coevolution of transcription factors and their binding sites in sequence space (Record no. 374019)

000 -LEADER
fixed length control field 03025ntm a22003377a 4500
003 - CONTROL NUMBER IDENTIFIER
control field AT-ISTA
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20190904114827.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 190819s2019 au ||||| m||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Transcribing agency IST
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Prizak, Roshan
9 (RLIN) 5881
245 ## - TITLE STATEMENT
Title Coevolution of transcription factors and their binding sites in sequence space
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Name of publisher, distributor, etc. IST Austria
Date of publication, distribution, etc. 2019
500 ## - GENERAL NOTE
General note Thesis
505 ## - FORMATTED CONTENTS NOTE
Formatted contents note Abstract
505 ## - FORMATTED CONTENTS NOTE
Formatted contents note About the Author
505 ## - FORMATTED CONTENTS NOTE
Formatted contents note List of Publications
505 ## - FORMATTED CONTENTS NOTE
Formatted contents note List of Tables
505 ## - FORMATTED CONTENTS NOTE
Formatted contents note List of Figures
505 ## - FORMATTED CONTENTS NOTE
Formatted contents note List of Abbreviations
505 ## - FORMATTED CONTENTS NOTE
Formatted contents note 0 Introduction
505 ## - FORMATTED CONTENTS NOTE
Formatted contents note 1 TF-DNA binding in sequence space
505 ## - FORMATTED CONTENTS NOTE
Formatted contents note 2 Crosstalk in gene regulation
505 ## - FORMATTED CONTENTS NOTE
Formatted contents note 3 General theoretical formulation of TF-BS coevolution
505 ## - FORMATTED CONTENTS NOTE
Formatted contents note 4 Coevolution of duplicated TFs with their binding sites
505 ## - FORMATTED CONTENTS NOTE
Formatted contents note 5 Bioinformatic analysis for the evolution of Zn-finger TFs
505 ## - FORMATTED CONTENTS NOTE
Formatted contents note Coevolution of transcription factors and their binding sites in sequence space
505 ## - FORMATTED CONTENTS NOTE
Formatted contents note Bibliography
520 ## - SUMMARY, ETC.
Summary, etc. Transcription factors, by binding to specific sequences on the DNA, control the precise spatio-temporal expression of genes inside a cell. However, this specificity is limited, leading to frequent incorrect binding of transcription factors that might have deleterious consequences on the cell. By constructing a biophysical model of TF-DNA binding in the context of gene regulation, I will first explore how regulatory constraints can strongly shape the distribution of a population in sequence space. Then, by directly linking this to a picture of multiple types of transcription factors performing their functions simultaneously inside the cell, I will explore the extent of regulatory crosstalk -- incorrect binding interactions between transcription factors and binding sites that lead to erroneous regulatory states -- and understand the constraints this places on the design of regulatory systems. I will then develop a generic theoretical framework to investigate the coevolution of multiple transcription factors and multiple binding sites, in the context of a gene regulatory network that performs a certain function. As a particular tractable version of this problem, I will consider the evolution of two transcription factors when they transmit upstream signals to downstream target genes. Specifically, I will describe the evolutionary steady states and the evolutionary pathways involved, along with their timescales, of a system that initially undergoes a transcription factor duplication event. To connect this important theoretical model to the prominent biological event of transcription factor duplication giving rise to paralogous families, I will then describe a bioinformatics analysis of C2H2 Zn-finger transcription factors, a major family in humans, and focus on the patterns of evolution that paralogs have undergone in their various protein domains in the recent past.
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://doi.org/10.15479/at:ista:th6071">https://doi.org/10.15479/at:ista:th6071</a>
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Permanent Location Current Location Date acquired Barcode Date last seen Price effective from Koha item type
  Not Lost       Library Library 2019-08-19 AT-ISTA#001870 2019-08-19 2019-08-19 Book

Powered by Koha