Arachidonate related lipid mediators [electronic resource] / edited by Robert C. Murphy, Frank A. Fitzpatrick.

Contributor(s): Murphy, Robert C | Fitzpatrick, Frank A
Material type: TextTextSeries: Methods in enzymology: v. 187.Publisher: San Diego : Academic Press, �1990Description: 1 online resource (xxxviii, 683 pages) : illustrationsContent type: text Media type: computer Carrier type: online resourceISBN: 0121820882; 9780121820886Subject(s): Eicosanoic acid | Prostaglandins | Leukotrienes | Platelet activating factor | Arachidonic Acids | Lipid Metabolism | Lipides | Arachidonique, Acide | Enzymologie | Eicosanoic acid | Leukotrienes | Platelet activating factor | Prostaglandins | Arachidonzuur | Stofwisseling | Lipiden | Eicosanoide | Aufsatzsammlung | Biochemie | Prostaglandine | Leukotriene | Platelet activating Factor | Phospholipase A2 | Phospholipide | Arachidons�aurestoffwechsel | Lipide | Gewebshormon | Mediator | LipidsGenre/Form: Electronic books.Additional physical formats: Print version:: No titleDDC classification: 574.19247 LOC classification: QP601 | .M4 v.187Online resources: Click here to access online
Contents:
Nomenclature / William L. Smith [and others] -- Electron-capture negative-ion chemical ionization mass spectrometry of lipid mediators / Ian A. Blair, Robert C. Murphy and Frank A. Fitzpatrick -- Enzyme immunoassays of eicosanoids using acetylcholinesterase / Philippe Pradelles [and others] -- Radioimmunoassay of 11-dehydrothromboxane B2 / Giovanni Ciabattoni [and others] -- Measurement of thromboxane metabolites by gas chromatography-mass spectrometry / Francesca Catella [and others] -- Quantification of 9[alpha],11[beta]-prostaglandin F2 by stable isotope dilution mass spectrometric assay / Daniel F. Wendelborn [and others] -- Immunoaffinity purification-chromatographic quantitative analysis of arachidonic acid metabolites / J. James Vrbanac [and others] -- Preparation of tetradeuterated leukotriene A4 methyl ester: methyl-[11,12,14,15-2H4]-(5S, 6S)-Oxido-(7E,9E,11Z,14Z)-eicosatetraenoate / J.P. Lellouche [and others] -- Quantitative gas chromatography-mass spectrometry analysis of leukotriene B4 / W. Rodney Mathews, Robert C. Murphy and Frank A. Fitzpatrick -- Enzyme immunoassays for leukotrienes C4 and E4 using acetylcholinesterase / Philippe Pradelles [and others] -- Quantitation of sulfidopeptide leukotrienes in biological fluids by gas chromatography-mass spectrometry / Robert C. Murphy [and others] -- Automated on-line extraction and profiling of lipoxygenase products of arachidonic acid by high-performance liquid chromatography / Pierre Borgeat [and others] -- Preparation of antibodies directed against leukotrienes / Edward C. Hayes, Robert C. Murphy and Frank A. Fitzpatrick -- Bioassay of paf-acether by rabbit platelet aggregation / Marie-Jeanne Bossant [and others] -- Bioassay of platelet-activating factor by release of [3H]serotonin / Peter M. Henson, Robert C. Murphy and Frank A. Fitzpatrick -- Quantitation of platelet-activating factor by gas chromatography-mass spectrometry / Keith L. Clay, Robert C. Murphy and Frank A. Fitzpatrick -- Quantitative analysis of platelet-activating factor by gas chromatography-negative-ion chemical ionization mass spectrometry / Walter C. Pickett [and others] -- Isolation of platelet-activating factor and purification by thin-layer chromatography / Donald J. Hanahan, Robert C. Murphy and Frank A. Fitzpatrick.
Separation and characterization of arachidonate-containing phosphoglycerides / Floyd H. Chilton, Robert C. Murphy and Frank A. Fitzpatrick -- High-performance liquid chromatography separation and determination of lipoxins / Charles N. Serhan, Robert C. Murphy and Frank A. Fitzpatrick -- Quantitation of epoxy- and dihydroxyeicosatrienoic acids by stable isotope-dilution mass spectrometry / John Turkw [and others] -- High-performance liquid chromatography for chiral analysis of eicosanoids / Alan R. Brash [and others] -- Extraction of phospholipids and analysis of phospholipid molecular species / George M. Patton [and others] -- Macrophage phospholipase A2 specific for sn-2-arachidonic acid / Christina C. Leslie, Robert C. Murphy and Frank A. Fitzpatrick -- Measurement of phosphoinositide-specific phospholipase c activity / John E. Bleasdale [and others] -- Solubilization of arachidonate-CoA ligase from cell membranes, chromatographic separation from nonspecific long-chain fatty acid CoA ligase, and isolation of mutant cell line defective in arachidonate-CoA ligase / Michael Laposata, Robert C. Murphy and Frank A. Fitzpatrick -- Preparation of prostaglandin H2: Extended purification/analysis scheme / Duane Venton [and others] -- Purification and properties of pregnancy-inducible rabbit lung cytochrome P-450 prostaglandin [omega]-hydroxylase / A. Scott Muerhoff [and others] -- Purification of arachidonate 5-lipoxygenase from potato tubers / Pallu Reddanna [and others] -- Leukotriene metabolism by isolated rat hepatocytes / Michael A. Shirley [and others] -- Purification and characterization of human lung leukotriene A4 hydrolase / Nobuya Ohishi [and others] -- Potato arachidonate 5-lipoxygenase: Purification, characterization, and preparation of 5(S)-hydroperoxyeicosatetraenoic acid / Takao Shimizu [and others] -- Leukotriene C4 synthase: Characterization in mouse mastocytoma cells / Mats S�oderstr�om [and others] -- Leukocyte arachidonate 5-lipoxygenase: Isolation and characterization / Carol A. Rouzer [and others] -- 1 Cytochrome P-450LTB and inactivation of leukotriene B4 / Roy J. Soberman, Robert C. Murphy and Frank A. Fitzpatrick -- Cytosolic liver Enzymes catalyzing hydrolysis of leukotriene A4 to leukotriene B4 and 5,6-dihydroxyeicosatetraenoic acid / Jesper Z. Haeggstr�om, Robert C. Murphy and Frank A. Fitzpatrick -- Purification and properties of leukotriene C4 synthase from guinea pig lung microsomes / Roy J. Soberman, Robert C. Murphy and Frank A. Fitzpatrick -- 1 Immunoaffinity purification of arachidonate 5-Lipoxygenase from porcine leukocytes / Natsuo Ueda [and others] -- Platelet-activating factor acetylhydrolase from human plasma / Diana M. Stafforini [and others] -- Synthesis of epoxyeicosatrienoic acids and heteroatom analogs / J.R. Falck [and others] -- Isolation of rabbit renomedullary cells and arachidonate metabolism / Mairead A. Arroll [and others] -- Ocular cytochrome P-450 metabolism of arachidonate: Synthesis and bioassay / Michal Laniado Schwartzman [and others] -- Cytochrome P-450 arachidonate oxygenase / Jorge H. Capdevila [and others] -- Radioligand binding assays for thromboxane A2/prostaglandin H2 receptors / Perry V. Halushka [and others] -- Thromboxane A2/prostaglandin H2 receptor antagonists / Guy C. Le Breton [and others] -- Assessment of leukotriene D4 receptor antagonists / David Aharony, Robert C. Murphy and Frank A. Fitzpatrick -- Sulfidopeptide leukotriene receptor binding assays / Seymour Mong, Robert C. Murphy and Frank A. Fitzpatrick.
Ginkgolides and platelet-activating factor binding sites / D.J. Hosford [and others] -- Kadsurenone and other related lignans as antagonists of platelet-activating factor receptor / T.Y. Shen [and others] -- Use of WEB 2086 and WEB 2170 as platelet-activating factor antagonists/at] / Jorge Casals-Stenzel [and others] -- Cloning of sheep and mouse prostaglandin endoperoxide synthases / David L. Dewitt [and others] -- Preparation and proteolytic cleavage of apoprostaglandin endoperoxide synthase / Rebecca Odenwaller [and others] -- Cloning of leukotriene A4 hydrolase cDNA / Olof R�admark [and others] -- Molecular biology and cloning of archidonate 5-lipoxygenase / Colin D. Funk [and others] -- Parietal cell preparation and arachidonate metabolism / N. Ann Payne [and others] -- Culture of bone marrow-derived mast cells: A model for studying oxidative metabolism of arachidonic acid and synthesis of other molecules derived from membrane phospholipids / Ehud Razin, Robert C. Murphy and Frank A. Fitzpatrick -- Endothelial cells for studies of platelet-activating factor and arachidonate metabolites / Guy A. Zimmerman [and others] -- Use of cultured cells to study arachidonic acid metabolism / Robert R. Gorman [and others] -- Eicosanoid biochemistry in cultured glomerular mesangial cells / Michael S. Simonson [and others] -- Leukotriene B4 biosynthesis by erythrocyte-neutrophil interactions / David A. Jones [and others] -- Leukotriene C4 biosynthesis during polymorphonuclear leukocyte-vascular cell interactions / Steven J. Feinmark, Robert C. Murphy and Frank A. Fitzpatrick -- Release and metabolism of leukotriene A4 in neutrophil-mast cell interactions / Clemens A. Dahinden [and others] -- Interaction between platelets and lymphocytes in biosynthesis of prostacyclin / Kenneth K. Wu [and others] -- Eicosanoid interactions between platelets, endothelial cells, and neutrophils / Aaron J. Marcus, Robert C. Murphy and Frank A. Fitzpatrick -- Isolated perfused rat lung in arachidonate studies / Shih-Wen Chang [and others] -- Isolated coronary-perfused mammalian heart: Assessment of eicosanoid and platelet-activating factor release and effects / Roberto Levi [and others] -- Preparation of human and animal lung tissue for eicosanoid research / T. Vigan�o [and others].
Summary: This volume includes information on arachidonic acid metabolites and platelet activating factor. Assays for the quantitative measurement of prostaglandins, leukotrienes, and platelet-activating factor, including enzyme immunoassays and mass spectrophotometric techniques, are presented. Preparation and analysis of cytochrome P-450 metabolites of arachidonic acid are discussed. The isolation, purification, and assay of enzymes important in the biosynthesis and metabolism of these lipids are included.
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Includes bibliographical references and indexes.

Nomenclature / William L. Smith [and others] -- Electron-capture negative-ion chemical ionization mass spectrometry of lipid mediators / Ian A. Blair, Robert C. Murphy and Frank A. Fitzpatrick -- Enzyme immunoassays of eicosanoids using acetylcholinesterase / Philippe Pradelles [and others] -- Radioimmunoassay of 11-dehydrothromboxane B2 / Giovanni Ciabattoni [and others] -- Measurement of thromboxane metabolites by gas chromatography-mass spectrometry / Francesca Catella [and others] -- Quantification of 9[alpha],11[beta]-prostaglandin F2 by stable isotope dilution mass spectrometric assay / Daniel F. Wendelborn [and others] -- Immunoaffinity purification-chromatographic quantitative analysis of arachidonic acid metabolites / J. James Vrbanac [and others] -- Preparation of tetradeuterated leukotriene A4 methyl ester: methyl-[11,12,14,15-2H4]-(5S, 6S)-Oxido-(7E,9E,11Z,14Z)-eicosatetraenoate / J.P. Lellouche [and others] -- Quantitative gas chromatography-mass spectrometry analysis of leukotriene B4 / W. Rodney Mathews, Robert C. Murphy and Frank A. Fitzpatrick -- Enzyme immunoassays for leukotrienes C4 and E4 using acetylcholinesterase / Philippe Pradelles [and others] -- Quantitation of sulfidopeptide leukotrienes in biological fluids by gas chromatography-mass spectrometry / Robert C. Murphy [and others] -- Automated on-line extraction and profiling of lipoxygenase products of arachidonic acid by high-performance liquid chromatography / Pierre Borgeat [and others] -- Preparation of antibodies directed against leukotrienes / Edward C. Hayes, Robert C. Murphy and Frank A. Fitzpatrick -- Bioassay of paf-acether by rabbit platelet aggregation / Marie-Jeanne Bossant [and others] -- Bioassay of platelet-activating factor by release of [3H]serotonin / Peter M. Henson, Robert C. Murphy and Frank A. Fitzpatrick -- Quantitation of platelet-activating factor by gas chromatography-mass spectrometry / Keith L. Clay, Robert C. Murphy and Frank A. Fitzpatrick -- Quantitative analysis of platelet-activating factor by gas chromatography-negative-ion chemical ionization mass spectrometry / Walter C. Pickett [and others] -- Isolation of platelet-activating factor and purification by thin-layer chromatography / Donald J. Hanahan, Robert C. Murphy and Frank A. Fitzpatrick.

Separation and characterization of arachidonate-containing phosphoglycerides / Floyd H. Chilton, Robert C. Murphy and Frank A. Fitzpatrick -- High-performance liquid chromatography separation and determination of lipoxins / Charles N. Serhan, Robert C. Murphy and Frank A. Fitzpatrick -- Quantitation of epoxy- and dihydroxyeicosatrienoic acids by stable isotope-dilution mass spectrometry / John Turkw [and others] -- High-performance liquid chromatography for chiral analysis of eicosanoids / Alan R. Brash [and others] -- Extraction of phospholipids and analysis of phospholipid molecular species / George M. Patton [and others] -- Macrophage phospholipase A2 specific for sn-2-arachidonic acid / Christina C. Leslie, Robert C. Murphy and Frank A. Fitzpatrick -- Measurement of phosphoinositide-specific phospholipase c activity / John E. Bleasdale [and others] -- Solubilization of arachidonate-CoA ligase from cell membranes, chromatographic separation from nonspecific long-chain fatty acid CoA ligase, and isolation of mutant cell line defective in arachidonate-CoA ligase / Michael Laposata, Robert C. Murphy and Frank A. Fitzpatrick -- Preparation of prostaglandin H2: Extended purification/analysis scheme / Duane Venton [and others] -- Purification and properties of pregnancy-inducible rabbit lung cytochrome P-450 prostaglandin [omega]-hydroxylase / A. Scott Muerhoff [and others] -- Purification of arachidonate 5-lipoxygenase from potato tubers / Pallu Reddanna [and others] -- Leukotriene metabolism by isolated rat hepatocytes / Michael A. Shirley [and others] -- Purification and characterization of human lung leukotriene A4 hydrolase / Nobuya Ohishi [and others] -- Potato arachidonate 5-lipoxygenase: Purification, characterization, and preparation of 5(S)-hydroperoxyeicosatetraenoic acid / Takao Shimizu [and others] -- Leukotriene C4 synthase: Characterization in mouse mastocytoma cells / Mats S�oderstr�om [and others] -- Leukocyte arachidonate 5-lipoxygenase: Isolation and characterization / Carol A. Rouzer [and others] -- 1 Cytochrome P-450LTB and inactivation of leukotriene B4 / Roy J. Soberman, Robert C. Murphy and Frank A. Fitzpatrick -- Cytosolic liver Enzymes catalyzing hydrolysis of leukotriene A4 to leukotriene B4 and 5,6-dihydroxyeicosatetraenoic acid / Jesper Z. Haeggstr�om, Robert C. Murphy and Frank A. Fitzpatrick -- Purification and properties of leukotriene C4 synthase from guinea pig lung microsomes / Roy J. Soberman, Robert C. Murphy and Frank A. Fitzpatrick -- 1 Immunoaffinity purification of arachidonate 5-Lipoxygenase from porcine leukocytes / Natsuo Ueda [and others] -- Platelet-activating factor acetylhydrolase from human plasma / Diana M. Stafforini [and others] -- Synthesis of epoxyeicosatrienoic acids and heteroatom analogs / J.R. Falck [and others] -- Isolation of rabbit renomedullary cells and arachidonate metabolism / Mairead A. Arroll [and others] -- Ocular cytochrome P-450 metabolism of arachidonate: Synthesis and bioassay / Michal Laniado Schwartzman [and others] -- Cytochrome P-450 arachidonate oxygenase / Jorge H. Capdevila [and others] -- Radioligand binding assays for thromboxane A2/prostaglandin H2 receptors / Perry V. Halushka [and others] -- Thromboxane A2/prostaglandin H2 receptor antagonists / Guy C. Le Breton [and others] -- Assessment of leukotriene D4 receptor antagonists / David Aharony, Robert C. Murphy and Frank A. Fitzpatrick -- Sulfidopeptide leukotriene receptor binding assays / Seymour Mong, Robert C. Murphy and Frank A. Fitzpatrick.

Ginkgolides and platelet-activating factor binding sites / D.J. Hosford [and others] -- Kadsurenone and other related lignans as antagonists of platelet-activating factor receptor / T.Y. Shen [and others] -- Use of WEB 2086 and WEB 2170 as platelet-activating factor antagonists/at] / Jorge Casals-Stenzel [and others] -- Cloning of sheep and mouse prostaglandin endoperoxide synthases / David L. Dewitt [and others] -- Preparation and proteolytic cleavage of apoprostaglandin endoperoxide synthase / Rebecca Odenwaller [and others] -- Cloning of leukotriene A4 hydrolase cDNA / Olof R�admark [and others] -- Molecular biology and cloning of archidonate 5-lipoxygenase / Colin D. Funk [and others] -- Parietal cell preparation and arachidonate metabolism / N. Ann Payne [and others] -- Culture of bone marrow-derived mast cells: A model for studying oxidative metabolism of arachidonic acid and synthesis of other molecules derived from membrane phospholipids / Ehud Razin, Robert C. Murphy and Frank A. Fitzpatrick -- Endothelial cells for studies of platelet-activating factor and arachidonate metabolites / Guy A. Zimmerman [and others] -- Use of cultured cells to study arachidonic acid metabolism / Robert R. Gorman [and others] -- Eicosanoid biochemistry in cultured glomerular mesangial cells / Michael S. Simonson [and others] -- Leukotriene B4 biosynthesis by erythrocyte-neutrophil interactions / David A. Jones [and others] -- Leukotriene C4 biosynthesis during polymorphonuclear leukocyte-vascular cell interactions / Steven J. Feinmark, Robert C. Murphy and Frank A. Fitzpatrick -- Release and metabolism of leukotriene A4 in neutrophil-mast cell interactions / Clemens A. Dahinden [and others] -- Interaction between platelets and lymphocytes in biosynthesis of prostacyclin / Kenneth K. Wu [and others] -- Eicosanoid interactions between platelets, endothelial cells, and neutrophils / Aaron J. Marcus, Robert C. Murphy and Frank A. Fitzpatrick -- Isolated perfused rat lung in arachidonate studies / Shih-Wen Chang [and others] -- Isolated coronary-perfused mammalian heart: Assessment of eicosanoid and platelet-activating factor release and effects / Roberto Levi [and others] -- Preparation of human and animal lung tissue for eicosanoid research / T. Vigan�o [and others].

This volume includes information on arachidonic acid metabolites and platelet activating factor. Assays for the quantitative measurement of prostaglandins, leukotrienes, and platelet-activating factor, including enzyme immunoassays and mass spectrophotometric techniques, are presented. Preparation and analysis of cytochrome P-450 metabolites of arachidonic acid are discussed. The isolation, purification, and assay of enzymes important in the biosynthesis and metabolism of these lipids are included.

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