Mathematical Oncology 2013 [electronic resource] / edited by Alberto d'Onofrio, Alberto Gandolfi.
Contributor(s): d'Onofrio, Alberto [editor.] | Gandolfi, Alberto [editor.] | SpringerLink (Online service)Material type: TextSeries: Modeling and Simulation in Science, Engineering and Technology: Publisher: New York, NY : Springer New York : Imprint: Birkhäuser, 2014Description: X, 334 p. 96 illus., 78 illus. in color. online resourceContent type: text Media type: computer Carrier type: online resourceISBN: 9781493904587Subject(s): Mathematics | Cancer research | Biomathematics | Biophysics | Biological physics | Mathematics | Physiological, Cellular and Medical Topics | Cancer Research | Biophysics and Biological PhysicsAdditional physical formats: Printed edition:: No titleDDC classification: 570.285 LOC classification: QH323.5Online resources: Click here to access online
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Part I: Cancer Onset and Early Growth -- Modeling spatial effects in carcinogenesis: stochastic and deterministic reaction-diffusion -- Conservation law in cancer modeling -- Avascular tumor growth modeling: physical insight in skin cancer -- Part II: Tumor and Inter-Cellular Interactions -- A cell population model structured by cell age incorporating cell-cell adhesion -- A general framework for multiscale modeling of tumor–immune system interactions -- The power of the tumor microenvironment: a systemic approach for a systemic disease -- Part III: Anti-Tumor Therapies -- Modeling immune-mediated tumor growth and treatment -- Hybrid multiscale approach in cancer modelling and treatment prediction -- Deterministic mathematical modelling for cancer chronotherapeutics: cell population dynamics and treatment optimization -- Tumor Microenvironment and Anticancer Therapies: An Optimal Control Approach.
With chapters on free boundaries, constitutive equations, stochastic dynamics, nonlinear diffusion–consumption, structured populations, and applications of optimal control theory, this volume presents the most significant recent results in the field of mathematical oncology. It highlights the work of world-class research teams, and explores how different researchers approach the same problem in various ways. Tumors are complex entities that present numerous challenges to the mathematical modeler. First and foremost, they grow. Thus their spatial mean field description involves a free boundary problem. Second, their interiors should be modeled as nontrivial porous media using constitutive equations. Third, at the end of anti-cancer therapy, a small number of malignant cells remain, making the post-treatment dynamics inherently stochastic. Fourth, the growth parameters of macroscopic tumors are non-constant, as are the parameters of anti-tumor therapies. Changes in these parameters may induce phenomena that are mathematically equivalent to phase transitions. Fifth, tumor vascular growth is random and self-similar. Finally, the drugs used in chemotherapy diffuse and are taken up by the cells in nonlinear ways. Mathematical Oncology 2013 will appeal to graduate students and researchers in biomathematics, computational and theoretical biology, biophysics, and bioengineering.