Alzheimer's disease : methods and protocols / edited by Nigel M. Hooper.

Contributor(s): Hooper, N. M | Humana Press
Material type: TextTextSeries: Methods in molecular medicine: 32.Publisher: Totowa, N.J. : Humana Press, ©2000Description: 1 online resource (xiv, 408 pages) : illustrationsContent type: text Media type: computer Carrier type: online resourceISBN: 9781592591954; 1592591957; 0585395071; 9780585395074; 1280821558; 9781280821554; 9786610821556; 6610821550Uniform titles: Biomedprotocols. Subject(s): Alzheimer's disease -- Molecular aspects -- Laboratory manuals | Alzheimer's disease -- Diagnosis -- Laboratory manuals | Molecular diagnosis -- Laboratory manuals | Proteins | Biology | Amyloidogenic Proteins | Tauopathies | Dementia | Protein Precursors | Protease Nexins | Amyloid | Brain Diseases | Proteinase Inhibitory Proteins, Secretory | Amino Acids, Peptides, and Proteins | Neurodegenerative Diseases | Neurocognitive Disorders | Biological Science Disciplines | Mental Disorders | Chemicals and Drugs | Central Nervous System Diseases | Nervous System Diseases | Natural Science Disciplines | Disciplines and Occupations | Psychiatry and Psychology | Disease | Membrane Proteins | Amyloid beta-Protein Precursor | Genetics | Alzheimer Disease | Alzheimer, Maladie d' -- Aspect moléculaire -- Manuels de laboratoire | Alzheimer, Maladie d' -- Diagnostic -- Manuels de laboratoire | Diagnostics moléculaires -- Manuels de laboratoire | HEALTH & FITNESS -- Diseases -- General | MEDICAL -- Clinical Medicine | MEDICAL -- Diseases | MEDICAL -- Evidence-Based Medicine | MEDICAL -- Internal Medicine | Alzheimer's disease -- Diagnosis | Alzheimer's disease -- Molecular aspects | Molecular diagnosis | Wetenschappelijke techniekenGenre/Form: Electronic books. | Laboratory manuals. Additional physical formats: Alzheimer's diseaseDDC classification: 616.8/31 LOC classification: RC523 | .A39746 2000Online resources: Click here to access online
Contents:
Introduction to Alzheimer's disease / D. Allsop-The genetics of Alzheimer's disease / N. Brindle and P.S. George-Hyslop-Advances in methodology and current prospects for primary drug therapies for Alzheimer's disease / D.S. Knopman-Production and functional assays of recombinant secreted amyloid precursor protein (app) (sappalpha) / S.W. Barger-Quantifying abeta(1-40) and abeta (1-42) using sandwich-elisa / D.M. Skovronsky [and others]-Electrophoretic separation and immunoblotting of abeta(1-40) and abeta (1-42) / M. Staufenbiel and P.A. Paganetti-Abeta-induced proinflammatory cytokine release from differentiated human thp-1 monocytes / K.R. Brunden [and others]-Effects of the beta-amyloid peptide on membrane ion permeability / H.A. Pearson-Analysis of beta-amyloid peptide degradation in vitro / B. Cordell and A. Naidu-Posttranslational modifications of amyloid precursor protein : Ectodomain phosphorylation and sulfation / J. Walter and C. Haass-Posttranslational modifications of the amyloid precursor protein : Glycosylation / C. Liu [and others]-Using an amyloid precursor protein (app) reporter to characterize alpha-secretase / S.B. Roberts-Inhibition of alpha-secretase by zinc metalloproteinase inhibitors / S. Parvathy, A.J. Turner and N.M. Hooper-Development of neoepitope antibodies against the beta-secretase cleavage site in the amyloid precursor protein / C.W. Gray and E.H. Karran-Beta-secretase : Tissue culture studies of sequence specificity, inhibitors, and candidate enzymes / M. Citron-Using beta-secretase inhibitors to distiguish the generation of the abeta peptides terminating at val-40 and ala-42 / P.A. Paganetti and M. Staufenbiel-Designing animal models of Alzheimer's disease with amyloid precursor protein (app) transgenes / J.F. Loring-Phosphorylation of amyloid precursor protein (app) family proteins / T. Suzuki [and others]-Determining the transmembrane topology of the presenilins / G. Thinakaran and A. Doan-Normal proteolytic processing of the presenilins / H. Hartmann and B.A. Yankner-Apoptotic proteolytic cleavage of the presenilins by caspases / T.W. Kim-The phosphorylation of presenilin proteins / J. Walter-Interaction of the presenilins with the amyloid precursor protein (APP) / A. Weidemann [and others]-Distribution of presenilins and amyloid precursor protein (APP) in detergent-insoluble membrane domains / E.T. Parkin, A.J. Turner and N.M. Hooper-Characterization and use of monoclonal antibodies to tau and paired helical filament tau / P. Davies-Tau phosphorylation both in vitro and in cells / C.H. Reynolds, G.M. Gibb and S. Lovestone-Transglutaminase-catalyzed formation of Alzheimer-like insoluble complexes from recombinant tau / B.J. Balin and D.M. Appelt.
Action note: digitized 2010 committed to preserve In: Springer ProtocolsSummary: With the molecular mechanisms underlying the various forms of muscular dystrophy now rapidly clarifying, precise diagnosis has become a reality, and even a requirement in clinical practice. In Muscular Dystrophy: Methods and Protocols, Katherine Bushby and Louise Anderson have assembled an outstanding collection of key techniques for the analysis of DNA and protein from patients suspected to suffer from muscular dystrophy. Each method is highly detailed to ensure success and is presented by a hands-on expert who uses it on a day-to-day basis. The various DNA techniques focus on both the X-linked muscular dystrophies and the autosomal recessive muscular dystrophies. The protein methods include expression analysis, multiplex western blot analysis, immunocytochemical analysis, and reviews of immunological reagants and of amplification systems. Also discussed are the use of animal models to understand human muscular dystrophy and the available options for gene-based therapy. Comprehensive and highly practical, Muscular Dystrophy: Methods and Protocols offers today{608}s diagnostic laboratories, basic and medical researchers, and active clinicians an authoritative collection of tools that will serve as exacting diagnostic tools as well as greatly empowering research on the novel therapeutics now beginning to emerge.
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Introduction to Alzheimer's disease / D. Allsop-The genetics of Alzheimer's disease / N. Brindle and P.S. George-Hyslop-Advances in methodology and current prospects for primary drug therapies for Alzheimer's disease / D.S. Knopman-Production and functional assays of recombinant secreted amyloid precursor protein (app) (sappalpha) / S.W. Barger-Quantifying abeta(1-40) and abeta (1-42) using sandwich-elisa / D.M. Skovronsky [and others]-Electrophoretic separation and immunoblotting of abeta(1-40) and abeta (1-42) / M. Staufenbiel and P.A. Paganetti-Abeta-induced proinflammatory cytokine release from differentiated human thp-1 monocytes / K.R. Brunden [and others]-Effects of the beta-amyloid peptide on membrane ion permeability / H.A. Pearson-Analysis of beta-amyloid peptide degradation in vitro / B. Cordell and A. Naidu-Posttranslational modifications of amyloid precursor protein : Ectodomain phosphorylation and sulfation / J. Walter and C. Haass-Posttranslational modifications of the amyloid precursor protein : Glycosylation / C. Liu [and others]-Using an amyloid precursor protein (app) reporter to characterize alpha-secretase / S.B. Roberts-Inhibition of alpha-secretase by zinc metalloproteinase inhibitors / S. Parvathy, A.J. Turner and N.M. Hooper-Development of neoepitope antibodies against the beta-secretase cleavage site in the amyloid precursor protein / C.W. Gray and E.H. Karran-Beta-secretase : Tissue culture studies of sequence specificity, inhibitors, and candidate enzymes / M. Citron-Using beta-secretase inhibitors to distiguish the generation of the abeta peptides terminating at val-40 and ala-42 / P.A. Paganetti and M. Staufenbiel-Designing animal models of Alzheimer's disease with amyloid precursor protein (app) transgenes / J.F. Loring-Phosphorylation of amyloid precursor protein (app) family proteins / T. Suzuki [and others]-Determining the transmembrane topology of the presenilins / G. Thinakaran and A. Doan-Normal proteolytic processing of the presenilins / H. Hartmann and B.A. Yankner-Apoptotic proteolytic cleavage of the presenilins by caspases / T.W. Kim-The phosphorylation of presenilin proteins / J. Walter-Interaction of the presenilins with the amyloid precursor protein (APP) / A. Weidemann [and others]-Distribution of presenilins and amyloid precursor protein (APP) in detergent-insoluble membrane domains / E.T. Parkin, A.J. Turner and N.M. Hooper-Characterization and use of monoclonal antibodies to tau and paired helical filament tau / P. Davies-Tau phosphorylation both in vitro and in cells / C.H. Reynolds, G.M. Gibb and S. Lovestone-Transglutaminase-catalyzed formation of Alzheimer-like insoluble complexes from recombinant tau / B.J. Balin and D.M. Appelt.

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With the molecular mechanisms underlying the various forms of muscular dystrophy now rapidly clarifying, precise diagnosis has become a reality, and even a requirement in clinical practice. In Muscular Dystrophy: Methods and Protocols, Katherine Bushby and Louise Anderson have assembled an outstanding collection of key techniques for the analysis of DNA and protein from patients suspected to suffer from muscular dystrophy. Each method is highly detailed to ensure success and is presented by a hands-on expert who uses it on a day-to-day basis. The various DNA techniques focus on both the X-linked muscular dystrophies and the autosomal recessive muscular dystrophies. The protein methods include expression analysis, multiplex western blot analysis, immunocytochemical analysis, and reviews of immunological reagants and of amplification systems. Also discussed are the use of animal models to understand human muscular dystrophy and the available options for gene-based therapy. Comprehensive and highly practical, Muscular Dystrophy: Methods and Protocols offers today{608}s diagnostic laboratories, basic and medical researchers, and active clinicians an authoritative collection of tools that will serve as exacting diagnostic tools as well as greatly empowering research on the novel therapeutics now beginning to emerge.

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