Psychiatric genetics : methods and reviews / edited by Marion Leboyer and Frank Bellivier.
Contributor(s): Leboyer, Marion | Bellivier, FrankMaterial type: TextSeries: Methods in molecular medicine: 77.Publisher: Totowa, N.J. : Humana Press, ©2003Description: 1 online resource (ix, 268 pages) : illustrationsContent type: text Media type: computer Carrier type: online resourceISBN: 1592593488; 9781592593484; 128084230X; 9781280842306; 9786610842308; 6610842302Subject(s): Mental illness -- Genetic aspects | Behavior genetics | Psychophysiology -- Genetic aspects | Mental Disorders -- genetics | Epidemiologic Research Design | Genetic Techniques | Mental Disorders -- epidemiology | Maladies mentales -- Aspect génétique | Génétique du comportement | Psychophysiologie -- Aspect génétique | MEDICAL -- Psychiatry -- General | PSYCHOLOGY -- Psychopathology -- General | PSYCHOLOGY -- Clinical Psychology | PSYCHOLOGY -- Mental Illness | MEDICAL -- Mental Health | Behavior genetics | Mental illness -- Genetic aspects | Psychophysiology -- Genetic aspects | Genetica | Psychische stoornissen | Wetenschappelijke techniekenGenre/Form: Electronic books. Additional physical formats: Print version:: Psychiatric genetics.DDC classification: 616.89/042 LOC classification: RC455.4.G4 | P785 2003Other classification: 44.91 Online resources: Click here to access online
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Includes bibliographical references and index.
Psychiatric genetics. Overview on achievements, problems, perspectives / W. Maier -- Analytical methods applied to psychiatric genetics / E.L. Grigorenko and D.L. Pauls -- Genetic markers in psychiatric genetics / T. Bourgeron and B. Giros -- Clinical assessment in psychiatric genetics / P. Gorwood -- Genetic association studies. Definition of cases and controls / F. Bellivier -- Searching for alternative phenotypes in psychiatric genetics / M. Leboyer -- Intermediate cognitive phenotypes associated with schizophrenia / M.F. Egan and T.E. Goldberg -- Biochemical endophenotypes in personality disorders / A.S. New and L.J. Siever -- Electrophysiological phenotypes / R. Freedman -- Brain imaging as an approach to phenotype characterization for genetic studies of schizophrenia / J.H. Callicott and D.R. Weinberger -- Psychiatric genetics. Future and prospects / M.T. Tsuang, L. Taylor and S.V. Faraone.
Print version record.
Enthusiasm about the role that genetics plays in our understanding of behavioral phenotypes has led to the development of many new epidemiological and statistical strategies, as well as to refinements in phenotype analysis. In Psychiatric Genetics: Methods and Reviews, hands-on experts comprehensively review the tools and methods currently available to uncover the genetic basis of psychiatric disorders, and then demonstrate through archetypical examples how these strategies can be used. Casting their net widely, the authors critically examine the key methodological issues involved in phenotypic analysis-including study design, molecular techniques, clinical interviews, and population sampling methods-and discuss new and alternate strategies that identify candidate symptoms and endophenotypes with better genetic validity. These strategies suggest cognitive intermediate phenotypes in schizophrenia, show how personality disorders may generate biologically mediated traits in the full-blown disorders, and yield data about P50 and P300 as endophenotypes in schizophrenia and alcoholism. One of the most promising approaches for the identification of valid phenotypes-the union of neuropsychological experimental designs and in vivo physiological brain mapping-is also discussed. Practical and timely, Psychiatric Genetics: Methods and Reviews lays the cornerstone for the new diagnostics in psychiatric genetics-the unraveling of the genetic basis of psychiatric disorders and the development of new therapies through the precise identification of the phenotypes involved.
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