Suicide gene therapy : methods and reviews / edited by Caroline J. Springer.

Contributor(s): Springer, Caroline J
Material type: TextTextSeries: Methods in molecular medicine: 90.Publisher: Totowa, N.J. : Humana Press, ©2004Description: 1 online resource (xiv, 555 pages) : illustrations (some color)Content type: text Media type: computer Carrier type: online resourceISBN: 9781592594290; 1592594298; 0896039714; 9780896039711Subject(s): Cancer -- Gene therapy | Neoplasms -- therapy | Genetic Therapy -- methods | Genes, Transgenic, Suicide | MEDICAL -- Oncology | HEALTH & FITNESS -- Diseases -- Cancer | Cancer -- Gene therapyGenre/Form: Electronic books. Additional physical formats: Print version:: Suicide gene therapy.DDC classification: 616.99/4042 LOC classification: RC271.G45 | S85 2004Online resources: Click here to access online
Contents:
Introduction to the background, principles, and state of the art in suicide gene therapy / I. Niculescu-Duvaz and C.J. Springer -- Introduction to vectors for suicide gene therapy / C.J. Springer -- Construction of VNP20009: a novel, genetically stable antibiotic-sensitive strain of tumor-targeting Salmonella for parenteral administration in humans / K.B. Low [and others] -- Nonreplicating DNA viral vectors for suicide gene therapy: the adenoviral vectors / M. Yamamoto and D.T. Curiel -- Replication-selective oncolytic adenoviruses / G. Hallden [and others] -- Retroviral vectors for suicide gene therapy / C. Porter -- Nonviral liposomes / A.D. Miller -- Peptide- and polymer-based gene delivery vehicles / R. Brokx and J. Gariepy -- Design of prodrugs for suicide gene therapy / D. Niculescu-Duvaz, I. Niculescu-Duvaz and C.J. Springer -- Cytochrome p450-based gene therapies for cancer / E.A. Chiocca and D.J. Waxman -- Tumor sensitization to purine analogs by E. coli PNP / K.V. Curlee, W.B. Parker and E.J. Sorscher -- Enzyme-prodrug systems: carboxylesterase/CPT-11 / M.K. Danks and P.M. Potter -- Enzyme-prodrug systems: thymidine phosphorylase/5'-deoxy-5-fluorouridine / A. Evrard [and others] -- Methods to improve efficacy in suicide gene therapy approaches: targeting prodrug-activating enzymes carboxypeptidase G2 and nitroreductase to different subcellular compartments / S. Schepelmann [and others] -- Extracellular beta-glucuronidase for gene-directed enzyme-prodrug therapy / S. Brusselbach -- Enhancement of suicide gene prodrug activation by random mutagenesis / J.E. Kurtz and M.E. Black -- Combination suicide gene therapy / W. Uckert [and others] -- Immune response to suicide gene therapy / S. Kuriyama, H. Tsujinoue and H. Yoshiji -- Targeting cancer with gene therapy using hypoxia as a stimulus / G.U. Dachs, O. Greco and G.M. Tozer -- Radiation-activated antitumor vectors / S.D. Scott and B. Marples -- In vitro and in vivo models for evaluation of GDEPT: quantifying bystander killing in cell cultures and tumors / W.R. Wilson [and others] -- Suicide gene therapy in liver tumors / L.R. Jiao [and others] -- Clinical trials with GDEPT: cytosine deaminase and 5-fluorocytosine / N.L. Brown and N.R. Lemoine -- The nitroreductase/CB1954 enzyme-prodrug system / N.K. Green [and others] -- Side effects of suicide gene therapy / M.M. van der Eb [and others] -- Antibody-directed enzyme-prodrug therapy / R.B. Pedley [and others] -- Bioreductive prodrugs for cancer therapy / B. Seddon, L.R. Kelland and P. Workman.
In: Springer ProtocolsSummary: Suicide gene therapy has become a major element in anticancer gene therapy and holds great promise for the future. In Suicide Gene Therapy: Methods and Reviews, prominent researchers and clinicians comprehensively detail the theory and practice of this exciting and elegant therapeutic approach. In their multidisciplinary treatment, the authors cover all the major aspects of suicide gene therapy, including the design and use of vectors in gene transduction, various enzyme and prodrug systems, the mechanistic analysis of the bystander effect, the design and synthesis of prodrugs, the immunological implications, and its clinical impact. They also describe and expound upon all the cutting-edge methods needed to explore, study, and advance understanding of the basic biology underlying gene therapy. Each fully tested method includes step-by-step instructions, a discussion of the principle behind the technique, equipment and reagent lists, tips on troubleshooting and avoiding pitfalls, and notes on the interpretation and use of results. Authoritative and up-to-date, Suicide Gene Therapy: Methods and Reviews not only summarizes our knowledge of suicide gene therapy today, but also provides the experimental means to advance its future development and therapeutic applications.
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Includes bibliographical references and index.

Introduction to the background, principles, and state of the art in suicide gene therapy / I. Niculescu-Duvaz and C.J. Springer -- Introduction to vectors for suicide gene therapy / C.J. Springer -- Construction of VNP20009: a novel, genetically stable antibiotic-sensitive strain of tumor-targeting Salmonella for parenteral administration in humans / K.B. Low [and others] -- Nonreplicating DNA viral vectors for suicide gene therapy: the adenoviral vectors / M. Yamamoto and D.T. Curiel -- Replication-selective oncolytic adenoviruses / G. Hallden [and others] -- Retroviral vectors for suicide gene therapy / C. Porter -- Nonviral liposomes / A.D. Miller -- Peptide- and polymer-based gene delivery vehicles / R. Brokx and J. Gariepy -- Design of prodrugs for suicide gene therapy / D. Niculescu-Duvaz, I. Niculescu-Duvaz and C.J. Springer -- Cytochrome p450-based gene therapies for cancer / E.A. Chiocca and D.J. Waxman -- Tumor sensitization to purine analogs by E. coli PNP / K.V. Curlee, W.B. Parker and E.J. Sorscher -- Enzyme-prodrug systems: carboxylesterase/CPT-11 / M.K. Danks and P.M. Potter -- Enzyme-prodrug systems: thymidine phosphorylase/5'-deoxy-5-fluorouridine / A. Evrard [and others] -- Methods to improve efficacy in suicide gene therapy approaches: targeting prodrug-activating enzymes carboxypeptidase G2 and nitroreductase to different subcellular compartments / S. Schepelmann [and others] -- Extracellular beta-glucuronidase for gene-directed enzyme-prodrug therapy / S. Brusselbach -- Enhancement of suicide gene prodrug activation by random mutagenesis / J.E. Kurtz and M.E. Black -- Combination suicide gene therapy / W. Uckert [and others] -- Immune response to suicide gene therapy / S. Kuriyama, H. Tsujinoue and H. Yoshiji -- Targeting cancer with gene therapy using hypoxia as a stimulus / G.U. Dachs, O. Greco and G.M. Tozer -- Radiation-activated antitumor vectors / S.D. Scott and B. Marples -- In vitro and in vivo models for evaluation of GDEPT: quantifying bystander killing in cell cultures and tumors / W.R. Wilson [and others] -- Suicide gene therapy in liver tumors / L.R. Jiao [and others] -- Clinical trials with GDEPT: cytosine deaminase and 5-fluorocytosine / N.L. Brown and N.R. Lemoine -- The nitroreductase/CB1954 enzyme-prodrug system / N.K. Green [and others] -- Side effects of suicide gene therapy / M.M. van der Eb [and others] -- Antibody-directed enzyme-prodrug therapy / R.B. Pedley [and others] -- Bioreductive prodrugs for cancer therapy / B. Seddon, L.R. Kelland and P. Workman.

Print version record.

Suicide gene therapy has become a major element in anticancer gene therapy and holds great promise for the future. In Suicide Gene Therapy: Methods and Reviews, prominent researchers and clinicians comprehensively detail the theory and practice of this exciting and elegant therapeutic approach. In their multidisciplinary treatment, the authors cover all the major aspects of suicide gene therapy, including the design and use of vectors in gene transduction, various enzyme and prodrug systems, the mechanistic analysis of the bystander effect, the design and synthesis of prodrugs, the immunological implications, and its clinical impact. They also describe and expound upon all the cutting-edge methods needed to explore, study, and advance understanding of the basic biology underlying gene therapy. Each fully tested method includes step-by-step instructions, a discussion of the principle behind the technique, equipment and reagent lists, tips on troubleshooting and avoiding pitfalls, and notes on the interpretation and use of results. Authoritative and up-to-date, Suicide Gene Therapy: Methods and Reviews not only summarizes our knowledge of suicide gene therapy today, but also provides the experimental means to advance its future development and therapeutic applications.

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