Vaccine adjuvants : preparation methods and research protocols / edited by Derek T. O'Hagan.Material type: TextSeries: Methods in molecular medicine ; v. 42.Publication details: Totowa, N.J. : Humana Press, 2000. Description: 1 online resource (x, 342 pages) : illustrationsContent type: text Media type: computer Carrier type: online resourceISBN: 9781592590834; 1592590837; 128082073X; 9781280820731; 9786610820733; 6610820732Subject(s): Immunological adjuvants | Vaccines | Vaccines | Adjuvants, Immunologic | Immunologic Factors | Biological Products | Complex Mixtures | Physiological Effects of Drugs | Chemicals and Drugs | Pharmacologic Actions | Chemical Actions and Uses | MEDICAL -- Pharmacology | Immunological adjuvants | Vaccines | Wetenschappelijke techniekenGenre/Form: Electronic books. Additional physical formats: Vaccine adjuvantsDDC classification: 615/.372 LOC classification: QR187.3 | .V33 2000NLM classification: QW 805Online resources: Click here to access online
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Includes bibliographical references and index.
An overview of adjuvant use -- Harmful and beneficial activities of immunological adjuvants -- Freund's adjuvants -- Aluminum compounds as vaccine adjuvants -- Poly(lactice-coglycolide) microparticles as vaccine adjuvants -- Poly(methyl methacrylate) nanoparticles as vaccine adjuvants -- Aqueous formulation of adjuvant-active nonionic block copolymers -- Liposomes as immunological adjuvants and vaccine carriers -- Immunopotentiating reconstituted indluezna virosomes (IRIVs) -- Cochleates for induction of mucosal and systemic immune responses -- Virus-like particles as vaccine adjuvants -- The adjuvant MF59: a 10 year perspective -- Preparation of the syntex adjuvant formulation (SAF, SAF-m, SAF-1) -- The ISCOM technology -- QS-21 adjuvant -- MPL Immunostimulant: adjuvant formulations -- Cytokines as vaccine adjuvants: the use of interleukin-2 -- DNA as an adjuvant -- Transcutaneous immunizaation -- Mutant heat-lbile enterotoxins as adjuvants for CTL induction.
Annotation Derek T. O'Hagan and a team of expert vaccinologists and pharmacologists thoroughly describe the preparation, characterization, and evaluation of a wide range of alternative vaccine adjuvants for use in preclinical studies. Each chapter carefully reviews a single adjuvant, and suggests why a specific adjuvant might be preferred for a given antigen, depending on what type of immune response is desired. Alternate adjuvant choices are also presented so that researchers can choose those most efficacious for their specific purpose. Comprehensive and highly practical, Vaccine Adjuvants: Preparation Methods and Research Protocols provides an effective guide to making and using vaccine adjuvants. By closely following directions from the book, today's researchers will be able optimally to induce specific immune responses against different types of antigens and to selectively manipulate the immune response in a favorable way.
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