Meningococcal vaccines : methods and protocols / edited by Andrew J. Pollard and Martin C.J. Maiden ; foreword by E. Richardson Moxon.

Contributor(s): Pollard, Andrew J | Maiden, Martin C. J
Material type: TextTextSeries: Methods in molecular medicine: 66.Publisher: Totowa, N.J. : Humana Press, ©2001Description: 1 online resource (xvii, 421 pages) : illustrationsContent type: text Media type: computer Carrier type: online resourceISBN: 0896038017; 9780896038011; 9781592591480; 1592591485Uniform titles: Meningococcal disease. Subject(s): Bacterial vaccines -- Laboratory manuals | Neisseria meningitidis -- Laboratory manuals | Meningitis -- Laboratory manuals | Meningococcal Vaccines | Meningitis, Meningococcal | Drug Therapy | Bacterial Vaccines | Meningococcal Infections | Meningitis, Bacterial | Therapeutics | Central Nervous System Bacterial Infections | Analytical, Diagnostic and Therapeutic Techniques and Equipment | Meningitis | Neisseriaceae Infections | Vaccines | Gram-Negative Bacterial Infections | Biological Products | Central Nervous System Infections | Bacterial Infections | Complex Mixtures | Bacterial Infections and Mycoses | Central Nervous System Diseases | Chemicals and Drugs | Nervous System Diseases | Disease | Vaccins antimicrobiens -- Manuels de laboratoire | Neisseria meningitidis -- Manuels de laboratoire | Méningite -- Manuels de laboratoire | HEALTH & FITNESS -- Diseases -- Nervous System (incl. Brain) | MEDICAL -- Neurology | Bacterial vaccines | Meningitis | Neisseria meningitidis | Meningokokken | Vaccins | Wetenschappelijke technieken | Meningitis cerebrospinalis epidemica | Impfstoff | HirnhautentzündungGenre/Form: Electronic books. | Laboratory manuals. Additional physical formats: Print version:: Meningococcal vaccines.; Online version:: Meningococcal vaccines.DDC classification: 616.8/2 LOC classification: QR189.5.B33 | M46 2001Other classification: 44.75 Online resources: Click here to access online
Contents:
Meningococcal vaccines and vaccine developments / I.M. Feavers -- Immune response and host-pathogen interactions / A.J. Pollard and D. Goldblatt -- Purification of capsular polysaccharide / Q. Yang and H. Jennings -- Protein-polysaccharide conjugation / Z. Guo and H. Jennings -- N -propionylation / Z. Guo and H. Jennings -- Outer membrane protein purification / C. Arigita [and others] -- Outer membrane protein vesicle vaccines for meningococcal disease / C.E. Frasch [and others] -- Methods for manipulation of transferrin-binding proteins / L.M. DeWinter and A.B. Schryvers -- Methods for the preparation and crystallization of fab fragments in complex with peptide antigens derived from N. Meningitidis outer membrane proteins / R.F. Collins and J.P. Derrick -- Application of optical biosensor techniques to the characterization of porA-antibody binding kinetics / J. Suker and B.M. Charalambous -- Construction of porA mutants / P. Ley and L. Alphen -- Construction of LPS mutants / P. Ley and L. Steeghs -- Recombinant proteins in vaccine development / M. Christodoulides, K.A. Jolley and J.E. Heckels -- Identification of peptides that mimic N. Meningitidis LOS epitopes via the use of combinatorial phage-display libraries / P.J. Brett, I.M. Feavers and B.M. Charalambous -- Testing meningococcal vaccines for mitogenicity and superantigenicity / A.A. Delvig, J.H. Robinson and L. Wetzler -- Early experiences with nasal vaccines against meningococcal disease / J. Holst and B. Haneberg -- Animal models for meningococcal disease / A.R. Gorringe [and others] -- Determination of antibody responses to meningococcal antigens by ELISA / E. Rosenqvist, H. Käyhty and A.J. Pollard -- Immunoblot analysis of sera from patients and vaccinees / E. Wedege -- Serogroup B and C serum bactericidal assays / R. Borrow and G.M. Carlone -- A modified ELISA for measurement of high-avidity IgG antibodies to meningococcal serogroup c polysaccharide that correlate with bactericidal titers / D.M. Granoff and J.J. Donnelly -- Whole-blood model / C.A. Ison -- Antibody-induced opsonophagocytosis of serogroup b meningococci measured by flow cytometry / T.E. Michaelsen and A. Aase -- T-cell responses against meningococcal antigens / L.M. Næss [and others] -- CF4 T-cell epitope mapping / A.A. Delvig and J.H. Robinson -- Epitope mapping / J.E. Heckels and M. Christodoulides -- Meningococcal vaccine trials / P. Farrington and E. Miller -- The introduction of group C conjugate meningococcal vaccine into the UK / D.M. Salisbury.
Action note: digitized 2010 committed to preserveSummary: The development of a comprehensive vaccine against Neisseria meningitidis, the causative agent of meningococcal disease, has remained elusive because of bacterial diversity and immunologic evasion. In Meningococcal Vaccines: Methods and Protocols, Andrew Pollard and Martin Maiden have assembled an impressive collection of the latest molecular and cellular techniques for the development, evaluation, and implementation of vaccines to be used against this dreaded disease. The contributors-leading scientists, clinicians, and public health physicians-describe in detail the many approaches to vaccine design, as well as the assessment of immune response to vaccine candidates and novel vaccine formulations. They also present as a test case the recent implementation of a new meningococcal vaccine in the United Kingdom. A companion volume, Meningococcal Disease: Methods and Protocols, contains detailed methods for diagnostic microbiology, bacterial characterization, epidemiology, host-pathogen interactions, and clinical studies. Timely and comprehensive, Meningococcal Vaccines: Methods and Protocols provides the scientist, public health physician, epidemiologist, clinical microbiologist, and clinician with the essential tools to lay bare the secrets of the meningococcus and to develop, evaluate, and implement successful new meningococcal vaccines.
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Companion volume to: Meningococal disease.

Includes bibliographical references and index.

Meningococcal vaccines and vaccine developments / I.M. Feavers -- Immune response and host-pathogen interactions / A.J. Pollard and D. Goldblatt -- Purification of capsular polysaccharide / Q. Yang and H. Jennings -- Protein-polysaccharide conjugation / Z. Guo and H. Jennings -- N -propionylation / Z. Guo and H. Jennings -- Outer membrane protein purification / C. Arigita [and others] -- Outer membrane protein vesicle vaccines for meningococcal disease / C.E. Frasch [and others] -- Methods for manipulation of transferrin-binding proteins / L.M. DeWinter and A.B. Schryvers -- Methods for the preparation and crystallization of fab fragments in complex with peptide antigens derived from N. Meningitidis outer membrane proteins / R.F. Collins and J.P. Derrick -- Application of optical biosensor techniques to the characterization of porA-antibody binding kinetics / J. Suker and B.M. Charalambous -- Construction of porA mutants / P. Ley and L. Alphen -- Construction of LPS mutants / P. Ley and L. Steeghs -- Recombinant proteins in vaccine development / M. Christodoulides, K.A. Jolley and J.E. Heckels -- Identification of peptides that mimic N. Meningitidis LOS epitopes via the use of combinatorial phage-display libraries / P.J. Brett, I.M. Feavers and B.M. Charalambous -- Testing meningococcal vaccines for mitogenicity and superantigenicity / A.A. Delvig, J.H. Robinson and L. Wetzler -- Early experiences with nasal vaccines against meningococcal disease / J. Holst and B. Haneberg -- Animal models for meningococcal disease / A.R. Gorringe [and others] -- Determination of antibody responses to meningococcal antigens by ELISA / E. Rosenqvist, H. Käyhty and A.J. Pollard -- Immunoblot analysis of sera from patients and vaccinees / E. Wedege -- Serogroup B and C serum bactericidal assays / R. Borrow and G.M. Carlone -- A modified ELISA for measurement of high-avidity IgG antibodies to meningococcal serogroup c polysaccharide that correlate with bactericidal titers / D.M. Granoff and J.J. Donnelly -- Whole-blood model / C.A. Ison -- Antibody-induced opsonophagocytosis of serogroup b meningococci measured by flow cytometry / T.E. Michaelsen and A. Aase -- T-cell responses against meningococcal antigens / L.M. Næss [and others] -- CF4 T-cell epitope mapping / A.A. Delvig and J.H. Robinson -- Epitope mapping / J.E. Heckels and M. Christodoulides -- Meningococcal vaccine trials / P. Farrington and E. Miller -- The introduction of group C conjugate meningococcal vaccine into the UK / D.M. Salisbury.

Print version record.

The development of a comprehensive vaccine against Neisseria meningitidis, the causative agent of meningococcal disease, has remained elusive because of bacterial diversity and immunologic evasion. In Meningococcal Vaccines: Methods and Protocols, Andrew Pollard and Martin Maiden have assembled an impressive collection of the latest molecular and cellular techniques for the development, evaluation, and implementation of vaccines to be used against this dreaded disease. The contributors-leading scientists, clinicians, and public health physicians-describe in detail the many approaches to vaccine design, as well as the assessment of immune response to vaccine candidates and novel vaccine formulations. They also present as a test case the recent implementation of a new meningococcal vaccine in the United Kingdom. A companion volume, Meningococcal Disease: Methods and Protocols, contains detailed methods for diagnostic microbiology, bacterial characterization, epidemiology, host-pathogen interactions, and clinical studies. Timely and comprehensive, Meningococcal Vaccines: Methods and Protocols provides the scientist, public health physician, epidemiologist, clinical microbiologist, and clinician with the essential tools to lay bare the secrets of the meningococcus and to develop, evaluate, and implement successful new meningococcal vaccines.

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