Cardiovascular disease. Volume 1, Genetics : methods and protocols / edited by Qing K. Wang.

Contributor(s): Wang, Qing K. (Qing Kenneth), 1965-
Material type: TextTextSeries: Methods in molecular medicine: 128.Publisher: Totowa, N.J. : Humana Press, ©2006Description: 1 online resource (1 volume) : illustrationsContent type: text Media type: computer Carrier type: online resourceISBN: 9781597451598; 1597451592; 1588295729; 9781588295729; 1280832460; 9781280832468; 9786610832460; 6610832463Other title: GeneticsSubject(s): Cardiovascular system -- Diseases -- Genetic aspects -- Laboratory manuals | Biochemistry | Publication Formats | Disease | Investigative Techniques | Biology | Biological Science Disciplines | Analytical, Diagnostic and Therapeutic Techniques and Equipment | Publication Characteristics | Chemistry | Natural Science Disciplines | Disciplines and Occupations | Laboratory Manuals | Molecular Biology | Methods | Cardiovascular Diseases | Genetics | Cardiovascular system -- Diseases -- Genetic aspects | geneeskunde | medicine | genetica | genetics | Medicine (General) | Geneeskunde (algemeen)Genre/Form: Electronic books. | Laboratory manuals. Additional physical formats: Print version:: Cardiovascular disease. Volume 1, Genetics.DDC classification: 616.1/042 LOC classification: RC687 | .C37 2006ebOnline resources: Click here to access online
Contents:
v. 1. Genetics: Cytogenetic analysis of cardiovascular disease: Karyotyping / M. Jarmuz [and others] -- Fluorescence in situ hybridization in cardiovascular disease / A.A. Timur [and others] -- Comparative genomic hybridization by microarray for the detection of cytogenetic imbalance / M. Jarmuz [and others] -- Construction of somatic cell hybrid lines: Fusion of mouse thymidine kinase-deficient 3T3 fibroblasts and human lymphoblastoid cells / A.A. Timur [and others] -- LINKAGE programs: Linkage analysis for monogenic cardiovascular diseases / L. Li [and others] -- SAGE programs: Model-free linkage analysis for complex cardiovascular phenotypes / S. Rao [and others] -- Linkage analysis for complex diseases using variance component analysis: SOLAR / U. Broeckel [and others] -- Genome resources and comparative analysis tools for cardiovascular research / G.E. Liu [and others] -- Positional cloning: Single-gene cardiovascular disorders / D. Li -- Positional cloning: Complex cardiovascular traits / J. Gulcher [and others] -- Chromosome substitution strains: A new way to study genetically complex traits / A.E. Hill [and others] -- Genome-wide association study to identify single-nucleotide polymorphisms conferring risk of myocardial infarction / K. Ozaki [and others] -- Mutation detection in congenital long qt syndrome: Cardiac channel gene screen using PCR, dHPLC, and direct DNA sequencing / D.J. Tester [and others] -- High-throughput single-nucleotide polymorphisms genotyping: TaqMan assay and pyrosequencing assay / G.Q. Shen [and others] -- Genotyping single-nucleotide polymorphisms by matrix-assisted laser desorption/ionization time-of-flight-based mini-sequencing / X. Sun [and others].
Summary: Cardiovascular disease is the leading cause of death in developed countries, but is quickly becoming an epidemic in such well-populated countries as China, India, and other developing nations. Cardiovascular research is the key to the prevention, diagnosis, and management of cardiovascular disease. Vigorous and cross-disciplinary approaches are required for successful card- vascular research. As the boundaries between different scientific disciplines, particularly in the life sciences, are weakening and disappearing, a successful investigator needs to be competent in many different areas, including genetics, cell biology, biochemistry, physiology, and structural biology. The newly developed field of molecular medicine is a cross-disciplinary science that seeks to comprehend disease causes and mechanisms at the molecular level, and to apply this basic research to the prevention, diagnosis, and treatment of diseases and disorders. This volume in the Methods in Molecular Medicine series, C- diovascular Disease, provides comprehensive coverage of both basic and the most advanced approaches to the study and characterization of cardiovascular disease. These methods will advance knowledge of the mechanisms, diagnoses, and treatments of cardiovascular disease. Cardiovascular Disease is a timely volume in which the theory and pr- ciples of each method are described in the Introduction section, followed by a detailed description of the materials and equipment needed, and step-by-step protocols for successful execution of the method. A notes section provides advice for potential problems, any modifications, and alternative methods.
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Includes bibliographical references and index.

v. 1. Genetics: Cytogenetic analysis of cardiovascular disease: Karyotyping / M. Jarmuz [and others] -- Fluorescence in situ hybridization in cardiovascular disease / A.A. Timur [and others] -- Comparative genomic hybridization by microarray for the detection of cytogenetic imbalance / M. Jarmuz [and others] -- Construction of somatic cell hybrid lines: Fusion of mouse thymidine kinase-deficient 3T3 fibroblasts and human lymphoblastoid cells / A.A. Timur [and others] -- LINKAGE programs: Linkage analysis for monogenic cardiovascular diseases / L. Li [and others] -- SAGE programs: Model-free linkage analysis for complex cardiovascular phenotypes / S. Rao [and others] -- Linkage analysis for complex diseases using variance component analysis: SOLAR / U. Broeckel [and others] -- Genome resources and comparative analysis tools for cardiovascular research / G.E. Liu [and others] -- Positional cloning: Single-gene cardiovascular disorders / D. Li -- Positional cloning: Complex cardiovascular traits / J. Gulcher [and others] -- Chromosome substitution strains: A new way to study genetically complex traits / A.E. Hill [and others] -- Genome-wide association study to identify single-nucleotide polymorphisms conferring risk of myocardial infarction / K. Ozaki [and others] -- Mutation detection in congenital long qt syndrome: Cardiac channel gene screen using PCR, dHPLC, and direct DNA sequencing / D.J. Tester [and others] -- High-throughput single-nucleotide polymorphisms genotyping: TaqMan assay and pyrosequencing assay / G.Q. Shen [and others] -- Genotyping single-nucleotide polymorphisms by matrix-assisted laser desorption/ionization time-of-flight-based mini-sequencing / X. Sun [and others].

Print version record.

Cardiovascular disease is the leading cause of death in developed countries, but is quickly becoming an epidemic in such well-populated countries as China, India, and other developing nations. Cardiovascular research is the key to the prevention, diagnosis, and management of cardiovascular disease. Vigorous and cross-disciplinary approaches are required for successful card- vascular research. As the boundaries between different scientific disciplines, particularly in the life sciences, are weakening and disappearing, a successful investigator needs to be competent in many different areas, including genetics, cell biology, biochemistry, physiology, and structural biology. The newly developed field of molecular medicine is a cross-disciplinary science that seeks to comprehend disease causes and mechanisms at the molecular level, and to apply this basic research to the prevention, diagnosis, and treatment of diseases and disorders. This volume in the Methods in Molecular Medicine series, C- diovascular Disease, provides comprehensive coverage of both basic and the most advanced approaches to the study and characterization of cardiovascular disease. These methods will advance knowledge of the mechanisms, diagnoses, and treatments of cardiovascular disease. Cardiovascular Disease is a timely volume in which the theory and pr- ciples of each method are described in the Introduction section, followed by a detailed description of the materials and equipment needed, and step-by-step protocols for successful execution of the method. A notes section provides advice for potential problems, any modifications, and alternative methods.

English.

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