Biomarker methods in drug discovery and development / edited by Feng Wang.

Contributor(s): Wang, Feng, 1961 January 27-
Material type: TextTextSeries: Methods in pharmacology and toxicology: Publisher: Totowa, NJ : Humana Press, ©2008Description: 1 online resource (xviii, 396 pages, 7 unnumbered pages of plates) : illustrationsContent type: text Media type: computer Carrier type: online resourceISBN: 9781597454636; 159745463XSubject(s): Biochemical markers | Drug development | Drug Design | Biomarkers, Pharmacological | Drug Discovery | Biomarkers | Chemistry, Pharmaceutical | Investigative Techniques | Biological Factors | Chemistry | Analytical, Diagnostic and Therapeutic Techniques and Equipment | Chemicals and Drugs | Pharmacology | Natural Science Disciplines | Biological Science Disciplines | Disciplines and Occupations | Biochemical markers | Drug development | nieuwe geneesmiddelen | new drugs | geneesmiddelenontwikkeling | drug development | farmacologie | pharmacology | biomarkers | Pharmacology | FarmacologieGenre/Form: Electronic books. Additional physical formats: Print version:: Biomarker methods in drug discovery and development.DDC classification: 615/.1 LOC classification: R853.B54 | B565 2008Online resources: Click here to access online
Contents:
Biomarker sample collection and handling in the clinical setting to support early phase drug development -- Gene Expression-Based Biomarkers of Drug Safety -- Profiling Gene Expression Signatures Using Fluorescent Microspheres -- Real-Time PCR Gene Expression Assays in Biomarker Discovery and Validation -- SAGE Analysis in Identifying Phenotype SNPs -- SNP and DNA Methylation Analysis using Pyrosequencing Methods -- The Application of LCM for the Analysis of Specific Cell-Type Gene Expression in a Complex Tissue: the Primate Endometrium -- The use of Two-Dimensional Gel Electrophoresis for Plasma Biomarker Discovery -- Difference In Gel Electrophoresis (DIGE), a high resolution protein biomarker research tool -- Label-free Mass Spectrometry-based Protein Quantification Technologies in Protein Biomarker Discovery -- Top-Down Quantitative Proteomic Analysis using a Highly Multiplexed Isobaric Mass Tagging Strategy -- SELDI Technology for Identification of Protein Biomarkers -- Sandwich ELISA Microarrays: Generating Reliable and Reproducible Assays for High Throughput Screens -- LC-MS Metabonomics Methodology in Biomarker Discovery -- GC/MS-based metabolomics -- NMR-Based Metabolomics for Biomarker Discovery -- Unraveling Glycerophospholipidomes by Lipidomics.
Summary: Within the pharmaceutical industry, the improvement of drug discovery and development efficiency and the expected personalization of medicine have become vitally important issues. In Biomarker Methods in Drug Discovery and Development, expert researchers provide a tool box for those who have a general interest in biomarker research and for those currently specializing in certain technologies but desiring an understanding of other available methodologies. Its chapters include validated, mature methods as well as new, incredibly promising protocols which aim to apply multiple technologies at different molecular levels in order to surmount the monumental and complex task of transforming the pharmaceutical research and development processes. As a volume in the Methods in Pharmacology and Toxicology™ series, this book offers user-friendly, step-by-step laboratory protocols for readily reproducible experiments. Comprehensive and state-of-the-art, Biomarker Methods in Drug Discovery and Development is the perfect biomarker technical guideline and reference to stimulate more exciting biomarker research and technology development.
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Includes bibliographical references and index.

Print version record.

Biomarker sample collection and handling in the clinical setting to support early phase drug development -- Gene Expression-Based Biomarkers of Drug Safety -- Profiling Gene Expression Signatures Using Fluorescent Microspheres -- Real-Time PCR Gene Expression Assays in Biomarker Discovery and Validation -- SAGE Analysis in Identifying Phenotype SNPs -- SNP and DNA Methylation Analysis using Pyrosequencing Methods -- The Application of LCM for the Analysis of Specific Cell-Type Gene Expression in a Complex Tissue: the Primate Endometrium -- The use of Two-Dimensional Gel Electrophoresis for Plasma Biomarker Discovery -- Difference In Gel Electrophoresis (DIGE), a high resolution protein biomarker research tool -- Label-free Mass Spectrometry-based Protein Quantification Technologies in Protein Biomarker Discovery -- Top-Down Quantitative Proteomic Analysis using a Highly Multiplexed Isobaric Mass Tagging Strategy -- SELDI Technology for Identification of Protein Biomarkers -- Sandwich ELISA Microarrays: Generating Reliable and Reproducible Assays for High Throughput Screens -- LC-MS Metabonomics Methodology in Biomarker Discovery -- GC/MS-based metabolomics -- NMR-Based Metabolomics for Biomarker Discovery -- Unraveling Glycerophospholipidomes by Lipidomics.

Within the pharmaceutical industry, the improvement of drug discovery and development efficiency and the expected personalization of medicine have become vitally important issues. In Biomarker Methods in Drug Discovery and Development, expert researchers provide a tool box for those who have a general interest in biomarker research and for those currently specializing in certain technologies but desiring an understanding of other available methodologies. Its chapters include validated, mature methods as well as new, incredibly promising protocols which aim to apply multiple technologies at different molecular levels in order to surmount the monumental and complex task of transforming the pharmaceutical research and development processes. As a volume in the Methods in Pharmacology and Toxicology™ series, this book offers user-friendly, step-by-step laboratory protocols for readily reproducible experiments. Comprehensive and state-of-the-art, Biomarker Methods in Drug Discovery and Development is the perfect biomarker technical guideline and reference to stimulate more exciting biomarker research and technology development.

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