Bioinformatics and drug discovery / edited by Richard S. Larson.

Contributor(s): Larson, Richard S
Material type: TextTextSeries: Methods in molecular biology (Clifton, N.J.): v. 316.Publisher: Totowa, N.J. : Humana Press, ©2006Description: 1 online resource (x, 444 pages) : illustrationsContent type: text Media type: computer Carrier type: online resourceISBN: 9781592599646; 1592599648Subject(s): Drug development | Bioinformatics | High throughput screening (Drug development) | Combinatorial chemistry | Computational Biology -- methods | Pharmacogenetics -- methods | Drug Design | Drug Evaluation, Preclinical | Genetic Techniques | Microarray Analysis | Pharmacology | Microchip Analytical Procedures | Investigative Techniques | Evaluation Studies as Topic | Drug Discovery | Biology | Genetics | Chemistry Techniques, Analytical | Chemistry, Pharmaceutical | Biological Science Disciplines | Analytical, Diagnostic and Therapeutic Techniques and Equipment | Health Occupations | Natural Science Disciplines | Disciplines and Occupations | Chemistry | Computational Biology | Pharmacogenetics | Methods | MEDICAL -- Drug Guides | MEDICAL -- Pharmacology | MEDICAL -- Pharmacy | MEDICAL -- Nursing -- Pharmacology | Bioinformatics | Combinatorial chemistry | Drug development | High throughput screening (Drug development) | Health & Biological Sciences | Pharmacy, Therapeutics, & Pharmacology | geneesmiddelen | drugs | bioinformatics | geneesmiddelenontwikkeling | drug development | laboratoriummethoden | laboratory methods | biologische technieken | biological techniques | moleculaire biologie | molecular biology | Pharmacology | Bioinformatics (General) | Farmacologie | Bioinformatica (algemeen)Genre/Form: Electronic books. | Electronic books. Additional physical formats: Print version:: Bioinformatics and drug discovery.DDC classification: 615/.19 LOC classification: RM301.25 | .B56 2005Online resources: Click here to access online
Contents:
New strategies in drug discovery / Eliot H. Ohlstein [and others] -- Basic microarray analysis : strategies for successful experiments / Scott A. Ness -- From microarray to biological networks : analysis of gene expression profiles / Xiwei Wu and T. Gregory Dewey -- Microarray analysis in drug discovery and clinical applications / Siqun Wang and Qiong Cheng -- Ontology-driven approaches to analyzing data in functional genomics / Francisco Azuje, Fatima Al-Shahrour, and Joaquin Dopazo -- Gene evolution and drug discovery / James O. McInerney [and others] -- Standardization of microarray and pharmacogenomics data / Cassey S. Husser [and others] -- Clinical applications of bioinformatics, genomics, and pharmacogenomics / Omer Iqbal.
Protein interactions probed with mass spectrometry / Suma Kaveti and John R. Engen -- Discovering new drug targeting sites on flexible multidomain protein kinases : -- Combining segmental isotopic and site-directed spin labeling for NMR detection of interfacial clefts / Thomas K. Harris -- NMR-based screening methods for drug discovery / Laurel Sillerud and Richard S. Larson -- Receptor binding sites : bioinformatic approaches / Darren R. Flower -- In silico protein design : fitting sequence onto structure / Bassil I. Dahiyat -- Chemical database preparation for compound acquisition or virtual screening / Cristian G. Bolgna, Marius M. Olah, and Tudor I. Oprea -- Bioinformatics platform development : from gene to lead compound / Alexis S. Ivanov [and others].
Summary: Many of the new technologies that are transforming drug discovery require a high degree of interdisciplinary expertise in physical science, life science, and computer science for bioinformatic analysis of their output. In Bioinformatics and Drug Discovery, a panel of researchers from academic and pharmaceutical laboratories describes readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described. The protocols follow the successful Methods in Molecular Biology series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and highly practical, Bioinformatics and Drug Discovery makes it possible to apply in the research laboratory the powerful new technologies that promise to greatly improve and speed up the discovery of new drugs.
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Includes bibliographical references and index.

New strategies in drug discovery / Eliot H. Ohlstein [and others] -- Basic microarray analysis : strategies for successful experiments / Scott A. Ness -- From microarray to biological networks : analysis of gene expression profiles / Xiwei Wu and T. Gregory Dewey -- Microarray analysis in drug discovery and clinical applications / Siqun Wang and Qiong Cheng -- Ontology-driven approaches to analyzing data in functional genomics / Francisco Azuje, Fatima Al-Shahrour, and Joaquin Dopazo -- Gene evolution and drug discovery / James O. McInerney [and others] -- Standardization of microarray and pharmacogenomics data / Cassey S. Husser [and others] -- Clinical applications of bioinformatics, genomics, and pharmacogenomics / Omer Iqbal.

Protein interactions probed with mass spectrometry / Suma Kaveti and John R. Engen -- Discovering new drug targeting sites on flexible multidomain protein kinases : -- Combining segmental isotopic and site-directed spin labeling for NMR detection of interfacial clefts / Thomas K. Harris -- NMR-based screening methods for drug discovery / Laurel Sillerud and Richard S. Larson -- Receptor binding sites : bioinformatic approaches / Darren R. Flower -- In silico protein design : fitting sequence onto structure / Bassil I. Dahiyat -- Chemical database preparation for compound acquisition or virtual screening / Cristian G. Bolgna, Marius M. Olah, and Tudor I. Oprea -- Bioinformatics platform development : from gene to lead compound / Alexis S. Ivanov [and others].

Print version record.

Many of the new technologies that are transforming drug discovery require a high degree of interdisciplinary expertise in physical science, life science, and computer science for bioinformatic analysis of their output. In Bioinformatics and Drug Discovery, a panel of researchers from academic and pharmaceutical laboratories describes readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described. The protocols follow the successful Methods in Molecular Biology series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and highly practical, Bioinformatics and Drug Discovery makes it possible to apply in the research laboratory the powerful new technologies that promise to greatly improve and speed up the discovery of new drugs.

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