High throughput screening : methods and protocols.

Contributor(s): Janzen, William P | Bernasconi, Paul
Material type: TextTextSeries: Springer protocols (Series): ; Methods in molecular biology (Clifton, N.J.): v. 565.Publisher: Dordrecht ; New York : Humana Press, ©2009Edition: 2nd ed. / edited by William P. Janzen and Paul BernasconiDescription: 1 online resource (xii, 268 pages : illustrations (some color))Content type: text Media type: computer Carrier type: online resourceISBN: 9781603272582; 1603272585Subject(s): High throughput screening (Drug development) | Drug Evaluation, Preclinical -- methods | Chemistry, Pharmaceutical | Combinatorial Chemistry Techniques | High throughput screening (Drug development) | verwerkingscapaciteit | throughput | nieuwe geneesmiddelen | new drugs | bioinformatics | dna libraries | Bioinformatics (General) | Bioinformatica (algemeen)Genre/Form: Electronic books. Additional physical formats: Print version:: High throughput screening.DDC classification: 660.6 LOC classification: RS419.5 | .H54 2009Online resources: Click here to access online
Contents:
Design and implementation of high-throughput screening assays / R. Macarrón and R.P. Hertzberg -- Creation of a small high-throughput screening facility / T. Flak -- Informatics in compound library management / M. Warne and L. Pemberton -- Statistics and decision making in high-throughput screening / I. Coma, J. Herranz and J. Martin -- Enzyme assay design for high-throughput screening / K.P. Williams and J.E. Scott -- Application of fluorescence polarization in HTS assays / X. Huang and A. Aulabaugh -- Screening G protein-coupled receptors: Measurement of intracellular calcium using the fluorometric imaging plate reader / R. Emkey and N.B. Rankl -- High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer / O.J. Trask [and others] -- Recent advances in electrophysiology-based screening technology and the impact upon ion channel discovery research / A. Southan and G. Clark -- Automated patch clamping using the QPatch / K.A. Jones [and others] -- High-throughput screening of the cyclic amp-dependent protein kinase (PKA) using the caliper microfluidic platform / L.J. Blackwell [and others] -- Use of primary human cells in high-throughput screens / A. Dunne, M. Jowett and S. Rees.
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Includes bibliographical references and index.

Design and implementation of high-throughput screening assays / R. Macarrón and R.P. Hertzberg -- Creation of a small high-throughput screening facility / T. Flak -- Informatics in compound library management / M. Warne and L. Pemberton -- Statistics and decision making in high-throughput screening / I. Coma, J. Herranz and J. Martin -- Enzyme assay design for high-throughput screening / K.P. Williams and J.E. Scott -- Application of fluorescence polarization in HTS assays / X. Huang and A. Aulabaugh -- Screening G protein-coupled receptors: Measurement of intracellular calcium using the fluorometric imaging plate reader / R. Emkey and N.B. Rankl -- High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer / O.J. Trask [and others] -- Recent advances in electrophysiology-based screening technology and the impact upon ion channel discovery research / A. Southan and G. Clark -- Automated patch clamping using the QPatch / K.A. Jones [and others] -- High-throughput screening of the cyclic amp-dependent protein kinase (PKA) using the caliper microfluidic platform / L.J. Blackwell [and others] -- Use of primary human cells in high-throughput screens / A. Dunne, M. Jowett and S. Rees.

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Electronic reproduction. [Place of publication not identified] : HathiTrust Digital Library, 2010. MiAaHDL

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