Therapeutic applications of RNAi : methods and protocols / edited by John F. Reidhaar-Olson, Cristina M. Rondinone.

Contributor(s): Reidhaar-Olson, John F | Rondinone, Cristina M
Material type: TextTextSeries: Springer protocols (Series): ; Methods in molecular biology (Clifton, N.J.): v. 555.Publisher: New York, NY : Humana Press, ©2009Description: 1 online resource (x, 148 pages) : illustrationsContent type: text Media type: computer Carrier type: online resourceISBN: 9781603272957; 160327295X; 9781603279932; 1603279938Subject(s): Small interfering RNA -- Therapeutic use | RNA Interference | Drug Discovery | Chemistry, Pharmaceutical | Gene Silencing | Investigative Techniques | Pharmacology | Analytical, Diagnostic and Therapeutic Techniques and Equipment | Chemistry | Epigenesis, Genetic | Natural Science Disciplines | Gene Expression Regulation | Biological Science Disciplines | Genetic Phenomena | Disciplines and Occupations | Phenomena and Processes | Interférence ARN -- Cahiers de laboratoire | Aufsatzsammlung | Geninaktivierung | RNS-Interferenz | ARN interférence | rna | interferentie | interference | geneesmiddelenbehandeling | drug therapy | methodologie | methodology | protocollen | protocols | Medicine (General) | Cellular Biology | Geneeskunde (algemeen) | CelbiologieGenre/Form: Laboratory Manual. | Aufsatzsammlung. Additional physical formats: Print version:: Therapeutic applications of RNAi.DDC classification: 572.88 LOC classification: QP623.5.S63Other classification: VS 9400 Online resources: Click here to access online | Click here to access online
Contents:
Development and application of a dual-purpose nanoparticle platform for delivery and imaging of siRNA in tumors / Z. Medarova [and others] -- Targeted gene silencing into solid tumors with electrically mediated siRNA delivery / M. Golzio [and others] -- Liposomal siRNA for ovarian cancer / L.S. Mangala [and others] -- Therapeutic applications of RNAi for silencing virus replication / R.A. Tripp and S.M. Tompkins -- RNAi in the malaria vector, Anopheles gambiae / F. Catteruccia and E.A. Levashina -- RNAi using a chitosan/siRNA nanoparticle system: in vitro and in vivo applications / M.O. Andersen, K.A. Howard and J. Kjems -- Lentiviral and adeno-associated vector-based therapy for motor neuron disease through RNAi / C. Towne and P. Aebischer -- Studying autoimmunity by in vivo RNA interference / S. Kissler -- Transcriptional gene silencing using small RNAs / D.H. Kim and J.J. Rossi -- Alternative splicing as a therapeutic target for human diseases / K.J. Dery [and others].
Action note: digitized 2010 committed to preserveSummary: The phenomenon of RNA interference has rapidly moved from groundbreaking scientific discovery to promising therapeutic approach. However, even as RNAi-based drugs enter the clinic, significant challenges remain, particulary in the area of delivery. Therapeutic Applications of RNAi provides detailed protocols in key areas of current focus, including testing of delivery vehicles, identification of appropriate model systems, and evaluation of the effects of RNAi in vivo. Produced by a team of internationally renowned authors, the volume describes the therapeutic applications of RNAi and potential pitfalls in oncology, viral infections and CNS disease, using a variety of delivery methods, including liposomes, peptide-based nanoparticles, polycationic polymers, and viral vehicles. Written in the highly successful Methods in Molecular Biology series format, the chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Therapeutic Applications of RNAi is an ideal guide for scientists attempting to solve the numerous challenges in this field and revolutionize the treatment of disease.
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Includes bibliographical references and index.

Development and application of a dual-purpose nanoparticle platform for delivery and imaging of siRNA in tumors / Z. Medarova [and others] -- Targeted gene silencing into solid tumors with electrically mediated siRNA delivery / M. Golzio [and others] -- Liposomal siRNA for ovarian cancer / L.S. Mangala [and others] -- Therapeutic applications of RNAi for silencing virus replication / R.A. Tripp and S.M. Tompkins -- RNAi in the malaria vector, Anopheles gambiae / F. Catteruccia and E.A. Levashina -- RNAi using a chitosan/siRNA nanoparticle system: in vitro and in vivo applications / M.O. Andersen, K.A. Howard and J. Kjems -- Lentiviral and adeno-associated vector-based therapy for motor neuron disease through RNAi / C. Towne and P. Aebischer -- Studying autoimmunity by in vivo RNA interference / S. Kissler -- Transcriptional gene silencing using small RNAs / D.H. Kim and J.J. Rossi -- Alternative splicing as a therapeutic target for human diseases / K.J. Dery [and others].

Print version record.

The phenomenon of RNA interference has rapidly moved from groundbreaking scientific discovery to promising therapeutic approach. However, even as RNAi-based drugs enter the clinic, significant challenges remain, particulary in the area of delivery. Therapeutic Applications of RNAi provides detailed protocols in key areas of current focus, including testing of delivery vehicles, identification of appropriate model systems, and evaluation of the effects of RNAi in vivo. Produced by a team of internationally renowned authors, the volume describes the therapeutic applications of RNAi and potential pitfalls in oncology, viral infections and CNS disease, using a variety of delivery methods, including liposomes, peptide-based nanoparticles, polycationic polymers, and viral vehicles. Written in the highly successful Methods in Molecular Biology series format, the chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Therapeutic Applications of RNAi is an ideal guide for scientists attempting to solve the numerous challenges in this field and revolutionize the treatment of disease.

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