Includes bibliographical references and index.

1. Management of Information in Distributed Biomedical Collaboratories / David B. Keator -- 2. Enabling Public Data Sharing: Encouraging Scientific Discovery and Education / Christine Fennema-Notestine -- 3. Mediator Infrastructure for Information Integration and Semantic Data Integration Environment for Biomedical Research / Jeffrey S. Grethe, Edward Ross, David Little, Brian Sanders, Amarnath Gupta, and Vadim Astakhov -- 4. System Biology of Gene Regulation / Michael Baitaluk -- 5. Current Computational Methods for Prioritizing Candidate Regulatory Polymorphisms / Stephen Montgomery -- 6. Methods of Information Geometry in Computational System Biology (Consistency between Chemical and Biological Evolution) / Vadim Astakhov -- 7. Protein Structure Prediction Based on Sequence Similarity / Lukasz Jaroszewsky -- 8. Applications of Bioinformatics to Protein Structures: How Protein Structure and Bioinformatics Overlap / Gye Won Han, Chris Rife, and Michael R. Sawaya -- 9. Knowledge Discovery via Machine Learning for Neurodegenerative Disease Researchers / I. Burak Özyurt and Gregory G. Brown -- 10. Brain Model of Text Animation as a Data Mining Strategy / Tamara Astakhova and Vadim Astakhov -- 11. Processes Parallel Execution Using Grid Wizard Enterprise / Marco Ruiz -- 12. Single Sign-On in a Grid Portal / Ramil V. Manansala.

"In recent decades, bioinformatics has emerged as a dynamic area producing a wide spectrum of new approaches and playing an important role in modern biotechnological development. This book provides an overview of novel cyberinfrastructures which are currently under development in various biomedical centers around the world. The first three chapters demonstrate various architectures for large-scale collaboration which integrate scientific accord across multiple centers. The next five chapters demonstrate modern approaches currently used in various areas of bioinformatics. The final four chapters illustrate the software challenges and strategies to resolve those challenges for large-scale biomedical informatics projects"--Page v.

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