Chemogenomics : methods and applications / edited by Edgar Jacoby.
Contributor(s): Jacoby, EdgarMaterial type: TextSeries: Springer protocols (Series): ; Methods in molecular biology (Clifton, N.J.): v. 575.Publisher: New York, NY : Humana Press, ©2009Description: 1 online resource (x, 320 pages) : illustrations (some color)Content type: text Media type: computer Carrier type: online resourceISBN: 9781607612742; 1607612747Subject(s): Chemogenomics | Genomics | Pharmacogenetics | Laboratory Manuals | Combinatorial Chemistry Techniques | Drug Design | Methods | Pharmacology | Genetics | Technology, Pharmaceutical | Publication Formats | Investigative Techniques | Drug Discovery | Computational Biology | Chemistry, Pharmaceutical | Analytical, Diagnostic and Therapeutic Techniques and Equipment | Health Occupations | Biology | Biological Science Disciplines | Publication Characteristics | Natural Science Disciplines | Chemistry | Disciplines and Occupations | Chemogenomics | Génomique | Pharmacogénétique | Conception de médicaments | Recherche biomédicale | Chemische Genetik | Génétique moléculaire | genexpressieanalyse | genomics | Genome informatics | GenoominformaticaGenre/Form: Laboratory Manual. | Electronic books. Additional physical formats: Print version:: Chemogenomics.DDC classification: 615.19 LOC classification: RM301.3.G45Online resources: Click here to access online
|Item type||Current location||Collection||Call number||Status||Date due||Barcode||Item holds|
Includes bibliographical references and index.
Organizing bioactive compound discovery in target families / H. Peter Nestler -- Compound library design for target families / K.V. Balakin, Y.A. Ivanenkov, and N.P. Savchuk -- Targeting the purinome / Jeremy M. Murray and Dirksen E. Bussiere -- Cofactor chemogenomics / Ratna Singh and Andrea Mozzarelli -- Chemogenomics with protein secondary-structure mimetics / Garland R. Marshall, Daniel J. Kuster, and Ye Che -- Database systems for knowledge-based discovery / Sarma A.R.P. Jagarlapudi and K.V. Radha Kishan -- Knowledge-based virtual screening : application to the MDM4/p53 protein-protein interaction / Edgar Jacoby [and others] -- Off-target networks derived from ligand set similarity / Michael J. Keiser and Jérôme Hert -- Chemogenomic analysis of safety profiling data / Josef Scheiber and Jeremy L. Jenkins -- Network and pathway analysis of compound-protein interactions / Richard J. Brennan, Tatiana Nikolskya, and Svetlana Bureeva -- The flexible pocketome engine for structural chemogenomics / Ruben Abagyan and Irina Kufareva -- Structure-based chemogenomics : analysis of protein family landscapes / Bernard Pirard -- Hypothesis-driven screening / Ulrich Schopfer [and others].
Print version record.
The establishment, analysis, prediction, and expansion of a comprehensive ligand-target Structure-Activity Relationship (SAR) in the post-genomic era presents a key research challenge for this century. In Chemogenomics: Methods and Applications, experts from academia and industry explore cutting-edge in vitro and in silico approaches available today and outline the relevant aspects of chemistry, biology, and molecular informatics which are the cornerstones of chemogenomics, thus combining introductory concepts with detailed methods and protocols. Covering topics such as target family-oriented compound library design, drug discovery targeting the purinome and co-factor binding sites, as well as the pocketome engine and molecular interaction field approaches, the book emphasizes systemization as an advantage to furthering the difficult science of drug discovery. As a volume in the highly successful Methods in Molecular Biology series format, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and practical, Chemogenomics: Methods and Applications presents content which will be of enormous value to those striving for the discovery of new and better therapies for diseases.
Use copy Restrictions unspecified star MiAaHDL
Electronic reproduction. [Place of publication not identified] : HathiTrust Digital Library, 2010. MiAaHDL
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL