Cardiovascular genomics : methods and protocols / edited by Keith DiPetrillo.

Includes bibliographical references and index.

Modes of defining atherosclerosis in mouse models: relative merits and evolving standards / Alan Daugherty, Hong Lu, Deborah A. Howatt, Debra L. Rateri -- Evaluating micro- and macro-vascular disease, the end stage of atherosclerosis, in rat models / James C. Russell -- Non-invasive blood pressure measurement in mice / Minjie Feng, Keith DiPetrillo -- Direct blood pressure monitoring in laboratory rodents via implantable radio telemetry / Daniel A. Huetteman, Heather Bogie -- Measuring kidney function in conscious mice / David L. Mattson -- Ischemic stroke in mice and rats / Aysan Durukan, Turgut Tatlisumak -- Year: 2009; DOI: 10.1007/978-1-60761-247-6_6; Page Range: 95-114 -- Mouse surgical models in cardiovascular research / Oleg Tarnavski -- Echocardiographic examination in rats and mice / Jing Liu, Dean F. Rigel -- QTL mapping in intercross and backcross populations / Fei Zou -- Quantitative trait locus analysis using J/qtl / Randy Smith, Keith Sheppard, Keith DiPetrillo, Gary Churchill -- Computing genetic imprinting expressed by haplotypes / Yun Cheng, Arthur Berg, Song Wu, Yao Li, Rongling Wu -- Haplotype association mapping in mice / Shirng-Wern Tsaih, Ron Korstanje -- Candidate gene association analysis / Jonathan B. Singer -- Genome-wide association study in humans / J. Gustav Smith, Christopher Newton-Cheh -- Bioinformatics analysis of microarray data / Yunyu Zhang, Joseph Szustakowski, Martina Schinke -- eQTL analysis in mice and rats / Bruno M. Tesson, Ritsert C. Jansen -- eQTL analysis in humans / Lude Franke, Ritsert C. Jansen -- A Systematic strategy for the discovery of candidate genes responsible for phenotypic variation / Paul Fisher, Harry Noyes, Stephen Kemp, Robert Stevens, Andrew Brass.

Print version record.

As two of the leading causes of death worldwide, heart disease and stroke represent a clear target for genomic research aimed at deciphering the genes and cellular pathways that underlie cardiovascular disease and creating improved therapies. In Cardiovascular Genomics: Methods and Protocols, experts in the field provide methods for cardiovascular phenotyping of rodent models in the first section of the volume and for statistical and bioinformatic integration of phenotype data with genome-wide genotype and expression data in the second section. Understanding these diverse methods will allow an individual laboratory to utilize these genomic methods independently or to better prepare for collaboration with scientists having expertise in other disciplines in order to uncover genes affecting cardiovascular disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary equipment, materials, and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Cutting-edge and easy-to-use, Cardiovascular Genomics: Methods and Protocols will enable researchers to identify causal genes and novel molecular targets that can lead to vital new treatments for cardiovascular disease.

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