Microarray methods for drug discovery / edited by Sridar V. Chittur.

Contributor(s): Chittur, Sridar V
Material type: TextTextSeries: Springer protocols (Series): ; Methods in molecular biology (Clifton, N.J.): v. 632.Publisher: New York, N.Y. : Humana Press, ©2010Description: 1 online resource (xi, 284 pages) : illustrations (some color)Content type: text Media type: computer Carrier type: online resourceISBN: 9781607616634; 1607616637Subject(s): Drug development | High throughput screening (Drug development) | Microarray Analysis | Oligonucleotide Array Sequence Analysis | Drug Evaluation, Preclinical | Drug Discovery | Sequence Analysis | Chemistry, Pharmaceutical | Microchip Analytical Procedures | Evaluation Studies as Topic | Investigative Techniques | Molecular Probe Techniques | Nucleic Acid Hybridization | Genetic Techniques | Chemistry | Pharmacology | Chemistry Techniques, Analytical | Analytical, Diagnostic and Therapeutic Techniques and Equipment | Natural Science Disciplines | Biological Science Disciplines | Disciplines and Occupations | Drug development | High throughput screening (Drug development) | farmacologie | pharmacology | toxicologie | toxicology | biomedische wetenschappen | biomedicine | humane genetica | human genetics | Medicine (General) | Geneeskunde (algemeen)Genre/Form: Electronic books. Additional physical formats: Printed edition:: No titleDDC classification: 572.8636 LOC classification: RM301.25Online resources: Click here to access online
Contents:
Multicenter clinical sample collection for microarray analysis / T.S. Mondala, D.R. Salomon, and S.R. Head -- Isolation of total RNA from transgenic mouse melanoma subsets using fluorescence-activated cell sorting / S. Tighe and M.A. Held -- Microarray analysis of embryonic stem cells and differentiated embryoid bodies / A.C. Zambon and C.S. Barker -- Determination of alternate splicing events using the Affymetrix Exon 1.0 ST arrays / S. Subbaram [and others] -- Profiling microRNA expression with the illumina BeadChip platform / J. Tsao, P. Yau, and N. Winegarden -- TaqMan array cards in pharmaceutical research / D.N. Keys, J.K. Au-Young, and R.A. Fekete -- DMET microarray technology for pharmacogenomics-based personalized medicine / J.K. Burmester [and others] -- The use of microarray technology for cytogenetics / B.A. Bejjani, L.G. Shaffer, and B.C. Ballif -- PCR/LDR/universal array platforms for the diagnosis of infectious disease / M. Pingle [and others] -- RIP-CHIP in drug development / R. Jain [and others] -- ChIPing away at global transcriptional regulation / K. Jackson, J. Paris, and M. Takahashi -- HELP (HpaII tiny fragment enrichment by ligation-mediated PCR) assay for DNA methylation profiling of primary normal and malignant B lymphocytes / R. Shaknovich, M.E. Figueroa, and A. Melnick -- High-throughput screening of metalloproteases using small molecule microarrays / M. Uttamchandani -- Metabolic enzyme microarray coupled with miniaturized cell-culture array technology for high-throughput toxicity screening / M. Lee, J.S. Dordick, and D.S. Clark -- Use of tissue microarray to facilitate oncology research / P. Gouveris, P.M. Weinberger, and A. Psyrri -- Small molecule selectivity and specificity profiling using functional protein microarrays / P.R. Kraus, L. Meng, and L. Freeman-Cook -- Production and application of glycan microarrays / J. Busch, R. McBride, and S.R. Head.
Summary: While the utilization of microarrays for gene expression studies has been widely published, Microarray Methods for Drug Discovery describes the use of this technology for a multitude of other vital applications. Covering the field of drug discovery through its various aspects, including high throughput screening, target identification, drug metabolism and toxicity screening as well as clinical sample handling, this volume also addresses new emerging fields like miRNA profiling, ribonomic and glycomic profiling. All chapters, contributed by experts in the field, follow the highly successful Methods in Molecular Biology series format, which is comprised of brief introductions, lists of required materials and reagents, readily reproducible, step-by-step lab protocols, along with detailed tips on troubleshooting and avoiding known pitfalls, making this book an easy read for investigators at all levels of expertise. Authoritative and cutting-edge, Microarray Methods for Drug Discovery provides an ideal desk reference for scientists who wish to use microarray technology in order to better understand a variety of biological interactions in their respective fields.
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Includes bibliographical references and index.

Multicenter clinical sample collection for microarray analysis / T.S. Mondala, D.R. Salomon, and S.R. Head -- Isolation of total RNA from transgenic mouse melanoma subsets using fluorescence-activated cell sorting / S. Tighe and M.A. Held -- Microarray analysis of embryonic stem cells and differentiated embryoid bodies / A.C. Zambon and C.S. Barker -- Determination of alternate splicing events using the Affymetrix Exon 1.0 ST arrays / S. Subbaram [and others] -- Profiling microRNA expression with the illumina BeadChip platform / J. Tsao, P. Yau, and N. Winegarden -- TaqMan array cards in pharmaceutical research / D.N. Keys, J.K. Au-Young, and R.A. Fekete -- DMET microarray technology for pharmacogenomics-based personalized medicine / J.K. Burmester [and others] -- The use of microarray technology for cytogenetics / B.A. Bejjani, L.G. Shaffer, and B.C. Ballif -- PCR/LDR/universal array platforms for the diagnosis of infectious disease / M. Pingle [and others] -- RIP-CHIP in drug development / R. Jain [and others] -- ChIPing away at global transcriptional regulation / K. Jackson, J. Paris, and M. Takahashi -- HELP (HpaII tiny fragment enrichment by ligation-mediated PCR) assay for DNA methylation profiling of primary normal and malignant B lymphocytes / R. Shaknovich, M.E. Figueroa, and A. Melnick -- High-throughput screening of metalloproteases using small molecule microarrays / M. Uttamchandani -- Metabolic enzyme microarray coupled with miniaturized cell-culture array technology for high-throughput toxicity screening / M. Lee, J.S. Dordick, and D.S. Clark -- Use of tissue microarray to facilitate oncology research / P. Gouveris, P.M. Weinberger, and A. Psyrri -- Small molecule selectivity and specificity profiling using functional protein microarrays / P.R. Kraus, L. Meng, and L. Freeman-Cook -- Production and application of glycan microarrays / J. Busch, R. McBride, and S.R. Head.

Print version record.

While the utilization of microarrays for gene expression studies has been widely published, Microarray Methods for Drug Discovery describes the use of this technology for a multitude of other vital applications. Covering the field of drug discovery through its various aspects, including high throughput screening, target identification, drug metabolism and toxicity screening as well as clinical sample handling, this volume also addresses new emerging fields like miRNA profiling, ribonomic and glycomic profiling. All chapters, contributed by experts in the field, follow the highly successful Methods in Molecular Biology series format, which is comprised of brief introductions, lists of required materials and reagents, readily reproducible, step-by-step lab protocols, along with detailed tips on troubleshooting and avoiding known pitfalls, making this book an easy read for investigators at all levels of expertise. Authoritative and cutting-edge, Microarray Methods for Drug Discovery provides an ideal desk reference for scientists who wish to use microarray technology in order to better understand a variety of biological interactions in their respective fields.

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