Photodynamic therapy : methods and protocols / edited by Charles J. Gomer.Material type: TextSeries: Springer protocols (Series) | Methods in molecular biology (Clifton, N.J.) ; v. 635.Publication details: New York, NY : Humana Press, ©2010. Description: 1 online resource (xi, 296 pages) : illustrationsContent type: text Media type: computer Carrier type: online resourceISBN: 9781607616979; 1607616971Subject(s): Photochemotherapy | Signal Transduction | Photochemotherapy | Methods | Laboratory Manuals | Neoplasms | Biochemical Phenomena | Publication Formats | Disease | Cell Physiological Phenomena | Combined Modality Therapy | Investigative Techniques | Phototherapy | Drug Therapy | Publication Characteristics | Analytical, Diagnostic and Therapeutic Techniques and Equipment | Chemical Phenomena | Therapeutics | Phenomena and Processes | Photochemotherapy | Oncology | Medicine | Health & Biological Sciences | geneeskunde | medicine | pathologie | pathology | biomedische wetenschappen | biomedicine | Medicine (General) | Geneeskunde (algemeen)Genre/Form: Laboratory Manual. | Electronic books. Additional physical formats: Print version:: Photodynamic therapy.DDC classification: 615.831 LOC classification: RC271.P43 | P46 2010NLM classification: W1 | WB 480Online resources: Click here to access online
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Includes bibliographical references and index.
Introduction / Thomas J. Dougherty -- Death and survival signals in photodynamic therapy / Michael Dewaele [and others] -- Photodynamc therapy and cell death pathways / David Kessel and Nancy L. Oleinick -- Identification of MAP kinase pathways involved in COX-2 expression following photfrin photodynamic therapy / Marian Luna [and others] -- Metronomic PDT and cell death pathways / Gurmit Sing, Omar Alqawi, and Myrna Espiritu -- How to monitor NF-[kappa]B activation after photodynamic therapy / Isabelle Coupienne, Jacques Piette, and Sébastien Bontems -- Application of 5-aminolevulinic acid and its derivatives for photodynamic therapy in vitro and in vivo / Asta Juzeniene, Petras Juzenas, and Johan Moan -- Hypoxia and perfusion labeling during photodynamic therapy / Theresa M. Busch -- Targeting the tumor microenvironment using photodynamic therapy combined with inhibitors of cyclooxygenase-2 or vascular endothelial growth factor / Angela Ferrario and Charles J. Gomer -- Photochemical internalization (PCI) : a technology for drug delivery / Kristian Berg [and others] -- Photodynamic therapy-generated cancer vaccines / Mladen Korbelik -- Antimicrobial photodynamic inactivation and photodynamic therapy for infections / Liyi Huang, Tianhong Dai, and Michael R. Hamblin -- Photodynamic therapy of bacterial and fungal biofilm infections / Merrill A. Biel -- Calculation of cellular oxygen concentration for photodynamic therapy in vitro / Michael S. Patterson and Emma Mazurek -- Fluorescent molecular imaging and dosimetry tools in photodynamic therapy / Brian W. Pogue [and others] -- Bifunctional agents for imaging and therapy / Ravindra K. Pandey [and others] -- Photodynamic diagnosis and therapy and the brain / Herwig Kostron -- Photodynamic therapy of head and neck cancers / Merrill A. Biel.
Print version record.
Biological interactions of visible light with photosensitizers have been studied for over a century while controlled clinical applications of light and photosensitizers to treat solid tumors, known as photodynamic therapy, have been evolving since the mid 1970's. In Photodynamic Therapy: Methods and Protocols, leading PDT scientists and clinicians provide the first comprehensive collection of methods and protocols specifically related to relevant mechanistic, dosimetric, preclinical, and clinical procedures used in current PDT research. Reflecting the growing number of studies demonstrating that immunological, tumor microenvironmental, and vascular responses are all contributing to PDT treatment outcomes, the contents of this volume move beyond the more traditional PDT concepts in order to investigate the numerous signal transduction and cell death pathways involved. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes which highlight tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Photodynamic Therapy: Methods and Protocols is an ideal guide for new investigators just starting out in PDT research as well as seasoned investigators changing the direction of their research with the intention of exploring this vital field of study.