Chemical library design / edited by Joe Zhongxiang Zhou.
Contributor(s): Zhou, Joe ZhongxiangMaterial type: TextSeries: Methods in molecular biology (Clifton, N.J.): v. 685.Publisher: [New York, N.Y.] : Humana Press, ©2011Description: 1 online resource (x, 362 pages) : illustrationsContent type: text Media type: computer Carrier type: online resourceISBN: 9781607619314; 1607619318; 9781607619307; 160761930XSubject(s): Combinatorial chemistry | Cheminformatics | Drugs -- Design | Chemistry -- methods | Combinatorial Chemistry Techniques -- methods | Drug Discovery -- methods | Small Molecule Libraries | Medical Informatics -- methods | Pharmaceutical Preparations -- chemistry | Cheminformatics | Combinatorial chemistry | Drugs -- Design | biochemie | biochemistry | chemie | chemistry | chemische verbindingen | chemical compounds | Chemistry (General) | Chemie (algemeen)Genre/Form: Electronic books. Additional physical formats: Print version:: Chemical library design.DDC classification: 615/.19 LOC classification: RS419 | .C54 2011Online resources: Click here to access online
|Item type||Current location||Collection||Call number||Status||Date due||Barcode||Item holds|
Includes bibliographical references and index.
Historical overview of chemical library design -- Chemoinformatics and library design -- Molecular library design using multi-objective optimization methods -- A scalable approach to combinatorial library design -- Application of free-Wilson selectivity analysis for combinatorial library design -- Application of QSAR and shape pharmacophore modeling approaches for targeted chemical library design -- Combinatorial library design from reagent pharmacophore fingerprints -- Docking methods for structure-based library design -- Structure-based library design in efficient discovery of novel inhibitors -- Structure-based and property-compliant library design of 11[beta]-HSD1 adamantyl amide inhibitors -- Design of screening collections for successful fragment-based lead discovery -- Fragment-based drug design -- LEAP into the Pfizer Global Virtual Library (PGVL) space: Creation of readily synthesizable design ideas automatically -- The design, annotation, and application of a kinase-targeted library -- PGVL hub: An integrated desktop tool for medicinal chemists to streamline design and synthesis of chemical libraries and singleton compounds -- Design of targeted libraries against the human Chk1 kinase using PGVLhub -- GLARE: A tool for product-oriented design of combinatorial libraries -- CLEVER: A general design tool for combinatorial libraries.
Print version record.
Chemical library technologies have brought about dramatic changes in the drug discovery process, and, though still evolving, they have become an integral part of ongoing drug discovery research. In Chemical Library Design, experts in the field provide methods and detailed protocols delving into this key process of selecting useful, biologically relevant compounds from large pools of synthesizable candidates. This compendium includes chapters on historical overviews, state-of-the-art methodologies, including structure-based and fragment-based library design, practical software tools, and successful and important applications of chemical library design. As a volume in the popular Methods in Molecular Biology series, the thorough contributions provide the kind of meticulous description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Chemical Library Design is an ideal reference for all scientists seeking the technology needed to aid in the search for new and vital drugs.