Photosensitive molecules for controlling biological function / edited by James J. Chambers, Richard H. Kramer.

Contributor(s): Chambers, James J | Kramer, Richard H
Material type: TextTextSeries: Springer protocols (Series): ; Neuromethods: 55.Publisher: New York, N.Y. : Humana Press, ©2011Description: 1 online resource (xiv, 297 pages) : illustrations (some color)Content type: text Media type: computer Carrier type: online resourceISBN: 9781617790317; 1617790311Subject(s): Photosensitization, Biological | Molecular neurobiology | Luminescent Proteins | Photoreceptor Cells | Neurobiology | Molecular neurobiology | Photosensitization, Biological | Human Anatomy & Physiology | Health & Biological Sciences | Neuroscience | neurochemie | neurochemistry | biomedische wetenschappen | biomedicine | neurowetenschap | neuroscience | neurobiologie | neurobiology | Medicine (General) | Geneeskunde (algemeen)Genre/Form: Electronic books. Additional physical formats: Print version:: Photosensitive molecules for controlling biological function.DDC classification: 573.8/4 LOC classification: QP82.2.L5 | P46 2011Online resources: Click here to access online
Contents:
Introduction to part I : caged neurotransmitters / James J. Chambers and Richard H. Kramer -- Targeting and excitation of photoactivatable molecules : design considerations for neurophysiology experiments / Eugene F. Civillico, J. Peter Rickgauer, and Samuel S.-H Wang -- Are caged compounds still useful / Graham C.R. Ellis-Davis -- Chromophores for the delivery of bioactive molecules with two-photon excitation / Timothy M. Dore and Hunter C. Wilson -- Introduction to part II : natural photosensitive proteins / James J. Chambers and Richard H. Kramer -- Light-activated ion pumps and channels for temporally precise optical control of activity in genetically targeted neurons / Brian Y. Chow [and others] -- Vertebrate and invertebrate rhodopsins : light control of G-protein signaling / Davina V. Gutierrez, Eugene Oh, and Stefan Herlitze -- Restoring visual function after photoreceptor degeneration : ectopic expression of photosensitive proteins in retinal neurons / Bin Lin and Richard H. Masland -- Introduction to part III : small molecule photoswitches / James J. Chambers and Richard H. Kramer -- Photoswitch design / Doris L. Fortin and Richard H. Kramer -- Optical manipulation of protein activity and protein interactions using caged proteins and optical switch protein conjugates / Yuling Yan and Gerard Marriott -- Structure-based design of light-controlled proteins / Harald Janovjak and Ehud Y. Isacoff -- Photoswitchable ligand-gated ion channels / Pau Gorostiza and Ehud Y. Isacoff.
Summary: The development of new photochemical tools, some synthesized by chemists and some provided by nature, is rapidly changing the way neurobiological research is performed in the modern laboratory. In Photosensitive Molecules for Controlling Biological Function, expert researchers in the field examine the most cutting-edge tools currently available. Divided into three sections, this detailed compendium features techniques involving natural photosensitive proteins, caged neurotransmitters, and small molecule photoswitches that bestow light sensitivity on ion channels and receptors. Written for the Neuromethods series, this volume features the type of meticulous description and implementation advice that is crucial for getting optimal results in the lab. Authoritative and practical, Photosensitive Molecules for Controlling Biological Function provides an unbiased comparison of the various photochemical tools currently available for controlling neuronal activity in order to aid scientists in the vital goal of choosing the right tools for the right job.
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Includes bibliographical references and index.

Introduction to part I : caged neurotransmitters / James J. Chambers and Richard H. Kramer -- Targeting and excitation of photoactivatable molecules : design considerations for neurophysiology experiments / Eugene F. Civillico, J. Peter Rickgauer, and Samuel S.-H Wang -- Are caged compounds still useful / Graham C.R. Ellis-Davis -- Chromophores for the delivery of bioactive molecules with two-photon excitation / Timothy M. Dore and Hunter C. Wilson -- Introduction to part II : natural photosensitive proteins / James J. Chambers and Richard H. Kramer -- Light-activated ion pumps and channels for temporally precise optical control of activity in genetically targeted neurons / Brian Y. Chow [and others] -- Vertebrate and invertebrate rhodopsins : light control of G-protein signaling / Davina V. Gutierrez, Eugene Oh, and Stefan Herlitze -- Restoring visual function after photoreceptor degeneration : ectopic expression of photosensitive proteins in retinal neurons / Bin Lin and Richard H. Masland -- Introduction to part III : small molecule photoswitches / James J. Chambers and Richard H. Kramer -- Photoswitch design / Doris L. Fortin and Richard H. Kramer -- Optical manipulation of protein activity and protein interactions using caged proteins and optical switch protein conjugates / Yuling Yan and Gerard Marriott -- Structure-based design of light-controlled proteins / Harald Janovjak and Ehud Y. Isacoff -- Photoswitchable ligand-gated ion channels / Pau Gorostiza and Ehud Y. Isacoff.

Print version record.

The development of new photochemical tools, some synthesized by chemists and some provided by nature, is rapidly changing the way neurobiological research is performed in the modern laboratory. In Photosensitive Molecules for Controlling Biological Function, expert researchers in the field examine the most cutting-edge tools currently available. Divided into three sections, this detailed compendium features techniques involving natural photosensitive proteins, caged neurotransmitters, and small molecule photoswitches that bestow light sensitivity on ion channels and receptors. Written for the Neuromethods series, this volume features the type of meticulous description and implementation advice that is crucial for getting optimal results in the lab. Authoritative and practical, Photosensitive Molecules for Controlling Biological Function provides an unbiased comparison of the various photochemical tools currently available for controlling neuronal activity in order to aid scientists in the vital goal of choosing the right tools for the right job.

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