Animal models of movement disorders. Volume II / edited by Emma L. Lane, Stephen B. Dunnett.Material type: TextSeries: NeuromethodsPublication details: New York : Humana Press, ©2011. Description: 1 online resource (xv, 443 pages)Content type: text Media type: computer Carrier type: online resourceISBN: 9781617793011; 1617793019; 9781617793004; 1617793000Subject(s): Movement disorders -- Animal models | Nervous System | Central Nervous System Diseases | Models, Animal | Models, Biological | Animal Diseases | Disease | Nervous System Diseases | Models, Theoretical | Anatomy | Investigative Techniques | Analytical, Diagnostic and Therapeutic Techniques and Equipment | Central Nervous System | Disease Models, Animal | Movement Disorders | Movement disorders -- Animal models | biomedische wetenschappen | biomedicine | neurowetenschap | neuroscience | neurologie | neurology | diermodellen | animal models | Medicine (General) | Geneeskunde (algemeen)Genre/Form: Electronic books. Additional physical formats: Printed edition:: No titleDDC classification: 616.8/3 LOC classification: RC376.5 | .A55 v.2NLM classification: WL 390Online resources: Click here to access online
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Part I Generic methods of assessment -- Why cannot a rodent be more like a man? a clinical perspective / Anne E. Rosser -- Zebrafish as a vertebrate model organism for studying movement disorders / Maria Sundvik and Pertti Panula -- Methodological strategies to evaluate functional effectors related to parkinson's disease through application of caenorhabditis elegans models / Kim A. Caldwell and Guy A. Caldwell -- Effects of alpha-synuclein expression on behavioral activity in drosophila : a simple model of parkinson's disease / Robert G. Pendleton [and others] -- Neurological evaluation of movement disorders in mice / Simon P. Brooks -- Rodent skilled reaching for modeling pathological conditions of the human motor system / Jenni M. Karl and Ian Q. Whishaw -- High-throughput mouse phenotyping / Sabine M. Holter and Lisa Glasl -- MRI of neurological damage in rats and mice / Mathias Hoehn -- Quantification of brain function and neurotransmission system in vivo by positron emission tomography : a review of technical aspects and practical considerations in preclinical research / Nadja Van Coup, Yann Bramoulle, and Philippe Hantraye -- Optical approaches to studying the basal ganglia / Joshua L. Plotkin [and others] -- Electrophysiological analysis of movement disorders in mice / Shilpa P. Rao [and others] -- Part II Dopamine systems -- Genetic models of parkinson's disease / Ralf Kuhn, Daniela Vogt-Weisenborn, and Wolfgang Wurst -- 6-OHDA lesion models of parkinson's disease in the rat / Eduardo M. Torres and Stephen B. Dunnett -- 6-OHDA toxin model in mouse / Gaynor A. Smith and Andreas Heuer -- Rotation in the 6-OHDA-lesioned rat / Stephen B. Dunnett and Eduardo M. Torres -- Of rats and patients : some thoughts about why rats turn in circles and parkinson's disease patients cannot move normally / Gordon W. Arbuthnott -- Comparing behavioral assessment of sensorimotor function in rat and mouse models of parkinson's disease and stroke / Sheila M. Fleming and Timothy Schallert -- Rodent models of 1-DOPA-induced dyskinesia / Hanna S. Lindgren and Emma L. Lane -- Using the MPTP mouse model to understand neuroplasticity : a new therapeutic target for parkinson's disease? / Giselle M. Petzinger [and others] -- MPTP-treated primate, with specific reference to the use of the common marmoset (callitbrix jacchus) / Michael J. Jackson and Peter Jenner -- Behavioral assessment in the african green monkey after MPTP administration / D. Eugene Redmond, Jr.
Movement is the way that animals interact with their environment and is under the organization and complex control of the brain and spinal cord. Multiple central nervous systems, including cortex, basal ganglia, cerebellum, and brainstem, interact to provide precise motor control and integration. Damage or disease within these systems cause profound motor disturbances in man, which can be effectively modeled in animals to develop a better understanding and treatment of the human condition. Animal Models of Movement Disorders introduces a variety of methods and techniques used to model and assess motor function in experimental animals from lower orders, such as drosophila and c. elegans, through vertebrate species including fish, to mammals, such as rodents and non-human primates. The most advanced contemporary models in each system are presented at multiple levels of analysis from molecular and genetic modeling, lesions, anatomy, neurochemistry, to imaging and behavior. Volume II of this detailed collection contains sections on the basal ganglia, neo- and allo-cortical systems, cerebellar and brain stem systems, as well as spinal cord systems. Comprehensive and meticulous, Animal Models of Movement Disorders serves as a valuable reference for those studying motor disorders by covering methodologies in detail and providing the information necessary to consider both the appropriate models and assessment tools that can most informatively answer the key experimental issues in the field.
Includes bibliographical references and index.