Cancer epigenetics : methods and protocols / edited by Ramona G. Dumitrescu, Mukesh Verma.

Contributor(s): Dumitrescu, Ramona G | Verma, Mukesh
Material type: TextTextSeries: Methods in molecular biology (Clifton, N.J.): v. 863.Publisher: New York : Humana Press, ©2012Description: 1 online resource (xiii, 492 pages)Content type: text Media type: computer Carrier type: online resourceISBN: 9781617796128; 1617796123; 1617796115; 9781617796111Subject(s): Cancer -- Genetic aspects -- Laboratory manuals | Epigenetics -- Laboratory manuals | Methylation | Genetic Phenomena | Biochemical Phenomena | Disease | Gene Expression Regulation | Alkylation | Chemical Phenomena | Metabolism | Phenomena and Processes | DNA Methylation | Neoplasms | Epigenesis, Genetic | Cancer -- Genetic aspects | Epigenetics | Medicine | Oncology | Biomedicine | Cancer Research | biomedische wetenschappen | neoplasms | Medicine (General) | Geneeskunde (algemeen)Genre/Form: Laboratory Manual. | Electronic books. | Laboratory manuals. Additional physical formats: Printed edition:: No titleDDC classification: 616.99/4042 LOC classification: RC268.4 | .C36 2012Online resources: Click here to access online
Contents:
Epigenetic markers of early tumor development / Ramona G. Dumitrescu -- Epigenetics of solid cancer stem cells / Alok Mishra and Mukesh Verma -- DNA methylation and histone modifications in breast cancer / Ramona G. Dumitrescu -- DNA methylation changes in prostate cancer / Wolfgang Goering, Michael Kloth, and Wolfgang A. Schulz -- DNA methylation in promoter region as biomarkers in prostate cancer / Mihi Yang and Jong Y. Park -- Epigenetics of bladder cancer / Wun-Jae Kim and Yong-June Kim -- Epigenetics in myeloid malignancies / Stefan Deneberg -- The epigenetics of brain tumors / Adrian M. Dubuc [and others] -- DNA methylation changes in cervical cancers / Qiang Lu, Dehua Ma, and Shuping Zhao -- Epigenetics of colon cancer / Sharad Khare and Mukesh Verma -- Promoter methylation in head and neck tumorigenesis / Jesena K. Stephen [and others] -- Epigenome and DNA methylation in oral squamous cell carcinoma / Mario Pérez-Sayáns García and Abel García-García -- Clinical implications of epigenetic alterations in human thoracic malignancies : epigenetic alterations in lung cancer / Keiko Shinjo and Yutaka Kondo -- The role of microRNAs in the management of liver cancer / Krishna K. Banaudha and Mukesh Verma -- Epigenetics in ovarian cancer / L.M.S. Seeber and P.J. van Diest -- DNA methylation in pancreatic cancer : protocols for the isolation of DNA and bisulfite modification / Katja Biewusch [and others] -- Detection and analysis of DNA methylation by pyrosequencing / Hilary A.A. Colyer [and others] -- Screening for miRNA expression changes using quantitative PCR (Q-PCR) / Richard N. Armstrong, Hilary A.A. Colyer, and Ken I. Mills -- Genome-wide methylation analysis / Alexander Unterberger, Adrian M. Dubuc, and Michael D. Taylor -- Microarray for epigenetic changes : gene expression arrays / Hilary A.A. Colyer, Richard N. Armstrong, and Ken I. Mills -- Detecting DNA methylation using the methylated CpG island amplification and microarray technique / Hilary A.A. Colyer, Margaret Dellett, and Ken I. Mills -- Nutrigenomics : implications for breast and colon cancer prevention / Gabriela Riscuta and Ramona G. Dumitrescu -- Dietary and lifestyle factors of DNA methylation / Unhee Lim and Min-Ae Song -- Diet, epigenetics, and cancer / L. Joseph Su -- Role of epigenetics in cancer health disparities / Sulma I. Mohammed, Sanya Springfield, and Rina Das -- Multifactorial etiology of gastric cancer / Jovanny Zabaleta -- Epigenetic epidemiology for cancer risk : harnessing germline epigenetic variation / Kevin Brennan and James M. Flanagan -- Epigenetic biomarkers in cancer epidemiology / Mukesh Verma.
Summary: The epigenetic regulation plays an important role in normal development and maintenance of tissue specific genes expression in humans and the disturbance of these patterns lead to changes involved in tumor formation. More recently, epigenetic changes have been observed in early stages of tumor development and together with the genetic alterations have been defined as abnormalities, necessary for cancer initiation and progression. In, Cancer Epigenetics: Methods and Protocols, expert researchers reviewed these epigenetics changes in different tumor types and described several technologies that are currently available to detect epigenetic changes. These technologies have lead to a better understanding of the processes in normal and cancerous cells. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Cancer Epigenetics: Methods and Protocols aids scientists in continuing to study epigenetic alterations used in clinical practice as biomarkers of early cancerous lesions or markers of progression and prognosis.
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Includes index.

Epigenetic markers of early tumor development / Ramona G. Dumitrescu -- Epigenetics of solid cancer stem cells / Alok Mishra and Mukesh Verma -- DNA methylation and histone modifications in breast cancer / Ramona G. Dumitrescu -- DNA methylation changes in prostate cancer / Wolfgang Goering, Michael Kloth, and Wolfgang A. Schulz -- DNA methylation in promoter region as biomarkers in prostate cancer / Mihi Yang and Jong Y. Park -- Epigenetics of bladder cancer / Wun-Jae Kim and Yong-June Kim -- Epigenetics in myeloid malignancies / Stefan Deneberg -- The epigenetics of brain tumors / Adrian M. Dubuc [and others] -- DNA methylation changes in cervical cancers / Qiang Lu, Dehua Ma, and Shuping Zhao -- Epigenetics of colon cancer / Sharad Khare and Mukesh Verma -- Promoter methylation in head and neck tumorigenesis / Jesena K. Stephen [and others] -- Epigenome and DNA methylation in oral squamous cell carcinoma / Mario Pérez-Sayáns García and Abel García-García -- Clinical implications of epigenetic alterations in human thoracic malignancies : epigenetic alterations in lung cancer / Keiko Shinjo and Yutaka Kondo -- The role of microRNAs in the management of liver cancer / Krishna K. Banaudha and Mukesh Verma -- Epigenetics in ovarian cancer / L.M.S. Seeber and P.J. van Diest -- DNA methylation in pancreatic cancer : protocols for the isolation of DNA and bisulfite modification / Katja Biewusch [and others] -- Detection and analysis of DNA methylation by pyrosequencing / Hilary A.A. Colyer [and others] -- Screening for miRNA expression changes using quantitative PCR (Q-PCR) / Richard N. Armstrong, Hilary A.A. Colyer, and Ken I. Mills -- Genome-wide methylation analysis / Alexander Unterberger, Adrian M. Dubuc, and Michael D. Taylor -- Microarray for epigenetic changes : gene expression arrays / Hilary A.A. Colyer, Richard N. Armstrong, and Ken I. Mills -- Detecting DNA methylation using the methylated CpG island amplification and microarray technique / Hilary A.A. Colyer, Margaret Dellett, and Ken I. Mills -- Nutrigenomics : implications for breast and colon cancer prevention / Gabriela Riscuta and Ramona G. Dumitrescu -- Dietary and lifestyle factors of DNA methylation / Unhee Lim and Min-Ae Song -- Diet, epigenetics, and cancer / L. Joseph Su -- Role of epigenetics in cancer health disparities / Sulma I. Mohammed, Sanya Springfield, and Rina Das -- Multifactorial etiology of gastric cancer / Jovanny Zabaleta -- Epigenetic epidemiology for cancer risk : harnessing germline epigenetic variation / Kevin Brennan and James M. Flanagan -- Epigenetic biomarkers in cancer epidemiology / Mukesh Verma.

The epigenetic regulation plays an important role in normal development and maintenance of tissue specific genes expression in humans and the disturbance of these patterns lead to changes involved in tumor formation. More recently, epigenetic changes have been observed in early stages of tumor development and together with the genetic alterations have been defined as abnormalities, necessary for cancer initiation and progression. In, Cancer Epigenetics: Methods and Protocols, expert researchers reviewed these epigenetics changes in different tumor types and described several technologies that are currently available to detect epigenetic changes. These technologies have lead to a better understanding of the processes in normal and cancerous cells. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Cancer Epigenetics: Methods and Protocols aids scientists in continuing to study epigenetic alterations used in clinical practice as biomarkers of early cancerous lesions or markers of progression and prognosis.

Includes bibliographical references and index.

English.

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