Molecular diagnostics for melanoma : methods and protocols / edited by Magdalena Thurin, Cancer Diagnosis Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, Francesco M. Marincola, Sidra Medical and Research Center, Qatar Foundation, Doha, Qatar.

Contributor(s): Thurin, Magdalena [editor.] | Marincola, Francesco M [editor.]
Material type: TextTextSeries: Methods in molecular biology (Clifton, N.J.): v. 1102.Publisher: New York : Humana Press, [2014]Copyright date: ©2014Description: 1 online resource (xxiii, 712 pages) : illustrations (some color)Content type: text Media type: computer Carrier type: online resourceISBN: 9781627037273; 1627037276; 1627037268; 9781627037266Subject(s): Melanoma -- Molecular diagnosis -- Laboratory manuals | Nevi and Melanomas | Analytical, Diagnostic and Therapeutic Techniques and Equipment | Clinical Laboratory Techniques | Investigative Techniques | Biological Factors | Neuroendocrine Tumors | Publication Formats | Genetic Techniques | Neuroectodermal Tumors | Publication Characteristics | Chemicals and Drugs | Neoplasms by Histologic Type | Neoplasms | Neoplasms, Nerve Tissue | Neoplasms, Germ Cell and Embryonal | Disease | Melanoma | Methods | Molecular Diagnostic Techniques | Biomarkers | Diagnosis | Laboratory Manuals | biomedische wetenschappen | biomedicine | neoplasms | oncologie | oncology | Medicine (General) | Geneeskunde (algemeen)Genre/Form: Electronic books. | Laboratory manuals. Additional physical formats: Print version:: Molecular diagnostics for melanoma.DDC classification: 616.99477 LOC classification: RC280.M37Online resources: Click here to access online
Contents:
Novel insights/translational implication from the emerging biology of melanoma / Antoni Ribas -- Emerging clinical issues in melanoma in the molecularly targeted era / Ryan J. Sullivan and Michael B. Atkins -- Integrating molecular biomarkers into current clinical management in melanoma / Ragini Kudchadkar, Geoffrey Gibney, and Vernon K. Sondak -- Advances in adjuvant therapy : potential for prognostic and predictive biomarkers / Diwakar Davar [and three others] -- Immunologic monitoring of cancer vaccine trials using the ELISPOT assay / Lisa H. Butterfield and Mary Jo Buffo -- Markers for anti-cytotoxic T-lymphocyte antigen 4 (CTLA- 4) therapy in melanoma / Michael A. Postow [and four others] -- Marker utility for combination therapy / Ester Simeone, Antonio M. Grimaldi, and Paolo A. Ascierto -- Assaying for BRAF V600E in tissue and blood in melanoma / David J. Panka, James W. Mier, and Ryan J. Sullivan -- Selecting patients for KIT inhibition in melanoma / Richard D. Carvajal, Omid Hamid, and Cristina R. Antonescu -- Detecting mechanisms of acquired BRAF inhibitor resistance in melanoma / Roger S. Lo and Hubing Shi -- Current status of diagnostic and prognostic markers in melanoma / Danielle Levine and David E. Fisher -- Chromosomal copy number analysis in melanoma diagnostics / Jeffrey P. North, Swapna S. Vemula, and Boris C. Bastian -- Construction and analysis of multiparameter prognostic models for melanoma outcome / Bonnie E. Gould Rothberg and David L. Rimm -- Immunohistochemical diagnostic and prognostic markers for melanoma / Mehdi Nosrati and Mohammed Kashani-Sabet -- Lymphatic invasion as a prognostic biomarker in primary cutaneous melanoma / Xiaowei Xu [and four others] -- Tumor-infiltrating lymphocytes and their significance in melanoma prognosis / Tobias Schatton [and three others] -- Pathological staging of melanoma / David E. Elder -- Genotyping of human leukocyte antigen (HLA) ancestral haplotypes as prognostic marker in cancer using PCR analysis / Lisa Villabona [and three others] -- B7-H abnormalities in melanoma and clinical relevance / Barbara Seliger -- Melanoma susceptibility genes and risk assessment / Alexander Marzuka-Alcalá, Michele Jacobs Gabree, and Hensin Tsao -- Clinical, pathologic, and imaging features and biological markers of uveal melanoma / Alia B. Rashid and Hans E. Grossniklaus -- Prognostic test to predict the risk of metastasis in uveal melanoma based on a 15-gene expression profile / J. William Harbour -- Molecular karyotyping for detection of prognostic markers in fine needle aspiration biopsy samples of uveal melanoma / Arupa Ganguly, Jennifer Richards-Yutz, and Kathryn G. Ewens -- ERBB4 mutation analysis : emerging molecular target for melanoma treatment / Christopher Lau [and three others] -- Epigenetic markers of prognosis in melanoma / Luca Sigalotti [and four others] -- Isolation of melanoma cell subpopulations using negative selection / Ana Slipicevic [and three others] -- Circulating tumor cells as prognostic biomarkers in cutaneous melanoma patients / Eiji Kiyohara [and three others] -- Detection of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma / Yangyang Wang [and three others] -- Targeting damage-associated molecular pattern molecules (DAMPs) and DAMP receptors in melanoma / Brian A. Boone and Michael T. Lotze -- The clinical use of PET/CT in the evaluation of melanoma / Khun Visith Keu and Andrei H. Iagaru -- Immune system functional pathway analysis using single cell network profiling (SCNP) : a novel tool in cancer immunotherapy / Alessandra Cesano and David Spellmeyer -- Quantitative and spatial image analysis of tumor and draining lymph nodes using immunohistochemistry and high-resolution multispectral imaging to prdict metastasis / Kim R.M. Blenman and Peter P. Lee -- COLD-PCR enriches low-level variant DNA sequences and increases the sensitivity of genetic testing / Elena Castellanos-Rizaldos [and seven others] -- Isolation of circulating microRNAs from microvesicles found in human plasma / John F. Quackenbush [and seven others] -- Detection of circulating tumor cells by photoacoustic flowmetry / Ryan M. Weight and John A. Viator -- Statistical design and evaluation of biomarker studies / Kevin K. Dobbin -- Tissue resources for clinical use and marker studies in melanoma / Jonathan L. Curry [and five others].
Summary: In Molecular Diagnostics for Melanoma: Methods and Protocols, expert researchers and clinicians in the field of melanoma provide updated information on biomarkers and assays for diagnosis, prognosis, and assays predicting response to treatment for routine testing. The focus of the volume is on biomarkers with established clinical validity rather than those on early discovery stage. With additional in-depth discussion of the molecular biology and pathology of melanoma, treatment options in adjuvant and metastatic setting, and implications of biomarker testing for clinical management of melanoma patients. Written in the highly successful Methods in Molecular Biology series format, chapters include extensive introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Molecular Diagnostics for Melanoma: Methods and Protocols seeks to provide both clinicians and scientists with technical information and extensive background information on the wide ranging approaches available in the field of diagnostics of melanoma.
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Novel insights/translational implication from the emerging biology of melanoma / Antoni Ribas -- Emerging clinical issues in melanoma in the molecularly targeted era / Ryan J. Sullivan and Michael B. Atkins -- Integrating molecular biomarkers into current clinical management in melanoma / Ragini Kudchadkar, Geoffrey Gibney, and Vernon K. Sondak -- Advances in adjuvant therapy : potential for prognostic and predictive biomarkers / Diwakar Davar [and three others] -- Immunologic monitoring of cancer vaccine trials using the ELISPOT assay / Lisa H. Butterfield and Mary Jo Buffo -- Markers for anti-cytotoxic T-lymphocyte antigen 4 (CTLA- 4) therapy in melanoma / Michael A. Postow [and four others] -- Marker utility for combination therapy / Ester Simeone, Antonio M. Grimaldi, and Paolo A. Ascierto -- Assaying for BRAF V600E in tissue and blood in melanoma / David J. Panka, James W. Mier, and Ryan J. Sullivan -- Selecting patients for KIT inhibition in melanoma / Richard D. Carvajal, Omid Hamid, and Cristina R. Antonescu -- Detecting mechanisms of acquired BRAF inhibitor resistance in melanoma / Roger S. Lo and Hubing Shi -- Current status of diagnostic and prognostic markers in melanoma / Danielle Levine and David E. Fisher -- Chromosomal copy number analysis in melanoma diagnostics / Jeffrey P. North, Swapna S. Vemula, and Boris C. Bastian -- Construction and analysis of multiparameter prognostic models for melanoma outcome / Bonnie E. Gould Rothberg and David L. Rimm -- Immunohistochemical diagnostic and prognostic markers for melanoma / Mehdi Nosrati and Mohammed Kashani-Sabet -- Lymphatic invasion as a prognostic biomarker in primary cutaneous melanoma / Xiaowei Xu [and four others] -- Tumor-infiltrating lymphocytes and their significance in melanoma prognosis / Tobias Schatton [and three others] -- Pathological staging of melanoma / David E. Elder -- Genotyping of human leukocyte antigen (HLA) ancestral haplotypes as prognostic marker in cancer using PCR analysis / Lisa Villabona [and three others] -- B7-H abnormalities in melanoma and clinical relevance / Barbara Seliger -- Melanoma susceptibility genes and risk assessment / Alexander Marzuka-Alcalá, Michele Jacobs Gabree, and Hensin Tsao -- Clinical, pathologic, and imaging features and biological markers of uveal melanoma / Alia B. Rashid and Hans E. Grossniklaus -- Prognostic test to predict the risk of metastasis in uveal melanoma based on a 15-gene expression profile / J. William Harbour -- Molecular karyotyping for detection of prognostic markers in fine needle aspiration biopsy samples of uveal melanoma / Arupa Ganguly, Jennifer Richards-Yutz, and Kathryn G. Ewens -- ERBB4 mutation analysis : emerging molecular target for melanoma treatment / Christopher Lau [and three others] -- Epigenetic markers of prognosis in melanoma / Luca Sigalotti [and four others] -- Isolation of melanoma cell subpopulations using negative selection / Ana Slipicevic [and three others] -- Circulating tumor cells as prognostic biomarkers in cutaneous melanoma patients / Eiji Kiyohara [and three others] -- Detection of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma / Yangyang Wang [and three others] -- Targeting damage-associated molecular pattern molecules (DAMPs) and DAMP receptors in melanoma / Brian A. Boone and Michael T. Lotze -- The clinical use of PET/CT in the evaluation of melanoma / Khun Visith Keu and Andrei H. Iagaru -- Immune system functional pathway analysis using single cell network profiling (SCNP) : a novel tool in cancer immunotherapy / Alessandra Cesano and David Spellmeyer -- Quantitative and spatial image analysis of tumor and draining lymph nodes using immunohistochemistry and high-resolution multispectral imaging to prdict metastasis / Kim R.M. Blenman and Peter P. Lee -- COLD-PCR enriches low-level variant DNA sequences and increases the sensitivity of genetic testing / Elena Castellanos-Rizaldos [and seven others] -- Isolation of circulating microRNAs from microvesicles found in human plasma / John F. Quackenbush [and seven others] -- Detection of circulating tumor cells by photoacoustic flowmetry / Ryan M. Weight and John A. Viator -- Statistical design and evaluation of biomarker studies / Kevin K. Dobbin -- Tissue resources for clinical use and marker studies in melanoma / Jonathan L. Curry [and five others].

Includes index.

In Molecular Diagnostics for Melanoma: Methods and Protocols, expert researchers and clinicians in the field of melanoma provide updated information on biomarkers and assays for diagnosis, prognosis, and assays predicting response to treatment for routine testing. The focus of the volume is on biomarkers with established clinical validity rather than those on early discovery stage. With additional in-depth discussion of the molecular biology and pathology of melanoma, treatment options in adjuvant and metastatic setting, and implications of biomarker testing for clinical management of melanoma patients. Written in the highly successful Methods in Molecular Biology series format, chapters include extensive introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Molecular Diagnostics for Melanoma: Methods and Protocols seeks to provide both clinicians and scientists with technical information and extensive background information on the wide ranging approaches available in the field of diagnostics of melanoma.

Online resource; title from PDF title page (SpringerLink, viewed November 25, 2013).

Includes bibliographical references and index.

English.

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