Clinical epidemiology : practice and methods / edited by Patrick S. Parfrey and Brendan J. Barrett.
Contributor(s): Parfrey, Patrick S [editor.] | Barrett, Brendan [editor.]Material type: TextSeries: Methods in molecular biology (Clifton, N.J.): v. 1281.; Springer protocols (Series): Publisher: New York, N.Y. : Humana Press : Springer, Copyright date: ©2015Edition: Second editionDescription: 1 online resource (xiii, 533 pages) : illustrationsContent type: text Media type: computer Carrier type: online resourceISBN: 9781493924288; 1493924281Subject(s): Epidemiology | Epidemiology -- Methodology | Epidemiologic Methods | Evidence-Based Practice | Research Design | Epidemiology | Epidemiology -- Methodology | geneeskunde | medicine | biomedische wetenschappen | biomedicine | Medicine (General) | Geneeskunde (algemeen)Genre/Form: Electronic books. Additional physical formats: Print version:: Clinical epidemiology.DDC classification: 614.4 LOC classification: RA652Online resources: Click here to access online
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Includes bibliographical references and index.
On framing the research question and choosing the appropriate research design / Patrick S. Parfrey and Pietro Ravani -- Research ethics for clinical researchers / John D. Harnett and Richard Neuman -- Definitions of bias in clinical research / Geoffrey Warden -- Longitudinal studies 1 : determination of risk / Sean W. Murphy -- Longitudinal studies 2 : modeling data using multivariate analysis / Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey -- Longitudinal studies 3 : data modeling using standard regression models and extensions / Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey -- Longitudinal studies 4 : matching strategies to evaluate risk / Matthew T. James -- Longitudinal studies 5 : development of risk prediction models for patients with chronic disease / Navdeep Tangri and Claudio Rigatto -- Randomized controlled trials 1 : design / Bryan M. Curtis, Brendan J. Barrett, and Patrick S. Parfrey -- Randomized controlled trials 2 : analysis / Robert N. Foley -- Randomized controlled trials 3 : measurement and analysis of patient-reported outcomes / Michelle M. Richardson, Megan E. Grobert, and Klemens B. Meyer -- Randomized controlled trials 4 : biomarkers and surrogate outcomes / Claudio Rigatto and Brendan J. Barrett -- Randomized controlled trials 5 : determining the sample size and power for clinical trials and cohort studies / Tom Greene -- Randomized controlled trials 6 : on contamination and estimating the actual treatment effect / Patrick S. Parfrey -- Randomized controlled trials 7 : analysis and interpretation of quality-of-life scores / Robert N. Foley and Patrick S. Parfrey -- Randomized controlled trials : planning, monitoring, and execution / Elizabeth Hatfield, Elizabeth Dicks, and Patrick S. Parfrey -- Evaluation of diagnostic tests / John M. Fardy and Brendan J. Barrett -- Qualitative research in clinical epidemiology / Deborah M. Gregory and Christine Y. Way -- Health economics in clinical research / Braden J. Manns -- Clinical genetic research 1 : bias / Susan Stuckless and Patrick S. Parfrey -- Clinical genetic research 2 : genetic epidemiology of complex phenotypes / Darren D. O'Rielly and Proton Rahman -- Clinical genetic research 3 : genetics ELSI (ethical, legal, and social issues) research / Daryl Pullman and Holly Etchegary -- Evidence-based decision-making 1 : critical appraisal / Laurie K. Twells -- Evidence-based decision-making 2: systematic reviews and meta-analysis / Aminu Bello, Natasha Wiebe, Amit Garg, and Marcello Tonelli -- Evidence-based decision-making 3 : health technology assessment / Daria O'Reilly [and 6 others] -- Evidence-based decision-making 4: development and limitations of clinical practice guidelines / Bruce Culleton -- Evidence-based decision-making 5 : translational research / Deborah M. Gregory and Laurie K. Twells -- Evidence-based decision-making 6 : utilization of administrative databases for health services research / Tanvir Turin Chowdhury and Brenda Hemmelgarn -- Evidence-based decision-making 7: knowledge translation / Braden J. Manns -- Evidence-based decision-making 8 : health policy, a primer for researchers / Victor Maddalena.
Focusing on improving the diagnosis, prognosis, and management of human disease, this book takes on the issues of research design, measurement, and evaluation which are critical to clinical epidemiology. This second edition of Clinical Epidemiology: Practice and Methods opens with how best to frame a clinical research question, the ethics associated with doing a research project in humans, and the definition of various biases that occur in clinical research. From there, it continues by examining issues of design, measurement, and analysis associated with various research designs, including determination of risk in longitudinal studies, assessment of therapy in randomized controlled clinical trials, and evaluation of diagnostic tests, and then delves into the more specialized area of clinical genetic research, before concluding with basic methods used in evidence-based decision making including critical appraisal, aggregation of multiple studies using meta-analysis, health technology assessment, clinical practice guidelines, development of health policy, translational research, how to utilize administrative databases, and knowledge translation. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and practical advice to ensure real world success. Comprehensive and authoritative, Clinical Epidemiology: Practice and Methods, Second Edition is intended to educate researchers on how to undertake clinical research and should be helpful not only to medical practitioners but also to basic scientists who want to extend their work to humans, to allied health professionals interested in scientific evaluation, and to trainees in clinical epidemiology.