Serotonin-Dopamine Interaction : Experimental Evidence and Therapeutic Relevance / edited by Giuseppe Di Giovanni, Vincenzo Di Matteo and Ennio Esposito.

Contributor(s): Di Giovanni, Giuseppe [editor,, dedicatee.] | Di Matteo, Vincenzo [editor.] | Esposito, Ennio [editor.]
Material type: TextTextSeries: Progress in brain research: v. 172.Publisher: Amsterdam ; New York : Elsevier, 2008Edition: First editionDescription: 1 online resource (xv, 665 pages, 6 pages of plates) : illustrations (some color)Content type: text Media type: computer Carrier type: online resourceISBN: 9780080932682; 0080932681; 9780444532350; 0444532358Subject(s): Serotonin -- Physiological effect -- Research | Serotonin -- Therapeutic use -- Research | Serotonin -- Antagonists -- Research | Dopamine -- Physiological effect -- Research | Dopamine -- Therapeutic use -- Research | Dopamine -- Agonists -- Research | Neurotransmitters -- Research | Neurochemistry | MEDICAL -- Neuroscience | PSYCHOLOGY -- Neuropsychology | Neurochemistry | Dopamine -- physiology | Serotonin -- physiology | Dopamine Agonists | Drug Interactions | Serotonin AgonistsGenre/Form: Electronic books. Additional physical formats: Print version:: Serotonin-dopamine interaction.DDC classification: 612.8042 LOC classification: QP376 | .P7 v.172ebOther classification: 44.90 Online resources: Click here to access online
Contents:
1. SEROTONIN-DOPAMINE INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM; 1. Serotonin-Dopamine Interaction: an overview; 2. Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies; 3. Serotonin-Dopamine Interaction: electrophysiological evidence; 4. Functional genetic polymorphisms in serotonin and dopamine gene systems and their significance in behavioural disorders; ; 2. SEROTONIN-DOPAMINE INTERACTIONS IN SCHIZOPHRENIA; 5. Distribution of 5-HT and DA receptors in primate prefrontal cortex: implications for pathophysiology and treatment; 6. Alterations of dopamine and serotonin transmission in schizophrenia; 7. Serotonin and dopamine interactions in psychosis prevention; 8. Role of serotonin and dopamine receptor binding in antipsychotic efficacy; 9. In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems; 10.
Neuropharmacology of second-generation antipsychotic drugs: a validity of the serotonin-dopamine hypothesis; 11. Serotonin-dopamine interactions: implications for the design of novel therapeutic agents for psychiatric disorders; ; 3. SEROTONIN-DOPAMINE INTERACTIONS IN DEPRESSION; 12. The dorsal raphe nucleus and serotonin -implications for neuroplasticity linked to major depression and Alzheimer's disease; 13. Dynamics of the dopaminergic system as a key component to the understanding of depression; 14. Physiological and therapeutic relevance of constitutive activity of 5-HT2A and 5-HT2C receptors for the treatment of depression; 15. The role of dopamine and serotonin in suicidal behaviour and aggression; ; 4. SEROTONIN-DOPAMINE INTERACTIONS IN DRUG ADDICTION; 16. Prospects for serotonin 5-HT2R pharmacotherapy in psychostimulant abuse; 17.
Pharmacological inhibition of dopamine- and serotonin activity blocks spontaneous and cocaine-activated behaviour; 18. Serotonin receptors as potential targets for modulation of nicotine use and dependence; 19. Dopamine/Serotonin releasers as medications for stimulant addictions; 20. PTEN-5-HT2C coupling: A new target for treating drug addiction; ; 5. SEROTONIN-DOPAMINE INTERACTIONS IN MOTOR DISORDERS; 21. Serotonin modulation of the basal ganglia circuitry: therapeutic implication for Parkinson's disease and other motor disorders; 22. Serotonin-Dopamine interaction in the induction and maintenance of LDOPA-induced dyskinesias; 23. Parkinson's disease -- opportunities for novel therapeutics to reduce the problems of levodopa therapy; 24. Neurobiological basis of serotonin-dopamine antagonists in the treatment of Gilles de la Tourette syndrome; ; 6. SEROTONIN-DOPAMINE INTERACTIONS IN ATTENTIONAL PROCESSES, LEARNING AND MEMORY; 25.
Serotonergic and dopaminergic modulation of attentional processes; 26. Dopamine-serotonin interactions in attention-deficit/hyperactivity disorder (ADHD); 27. Serotonin/dopamine interaction in learning; 28. Serotonin-dopamine interaction in memory formation; 29. The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking.
Summary: This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and behavioral data of the serotonin (5-HT)-dopamine (DA) interactions. Central serotonergic and dopaminergic systems play a critical role in the regulation of normal and abnormal behaviors. Moreover, recent evidence suggests that the dysfunction of the DA and 5-HT neurotransmitter systems contribute to various mental disorders including depression, schizophrenia, drug addiction and Parkinson?s disease. This extremely important topic is of wide interest within th.
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Text in English.

Includes bibliographical references and index.

This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and behavioral data of the serotonin (5-HT)-dopamine (DA) interactions. Central serotonergic and dopaminergic systems play a critical role in the regulation of normal and abnormal behaviors. Moreover, recent evidence suggests that the dysfunction of the DA and 5-HT neurotransmitter systems contribute to various mental disorders including depression, schizophrenia, drug addiction and Parkinson?s disease. This extremely important topic is of wide interest within th.

Print version record.

1. SEROTONIN-DOPAMINE INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM; 1. Serotonin-Dopamine Interaction: an overview; 2. Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies; 3. Serotonin-Dopamine Interaction: electrophysiological evidence; 4. Functional genetic polymorphisms in serotonin and dopamine gene systems and their significance in behavioural disorders; ; 2. SEROTONIN-DOPAMINE INTERACTIONS IN SCHIZOPHRENIA; 5. Distribution of 5-HT and DA receptors in primate prefrontal cortex: implications for pathophysiology and treatment; 6. Alterations of dopamine and serotonin transmission in schizophrenia; 7. Serotonin and dopamine interactions in psychosis prevention; 8. Role of serotonin and dopamine receptor binding in antipsychotic efficacy; 9. In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems; 10.

Neuropharmacology of second-generation antipsychotic drugs: a validity of the serotonin-dopamine hypothesis; 11. Serotonin-dopamine interactions: implications for the design of novel therapeutic agents for psychiatric disorders; ; 3. SEROTONIN-DOPAMINE INTERACTIONS IN DEPRESSION; 12. The dorsal raphe nucleus and serotonin -implications for neuroplasticity linked to major depression and Alzheimer's disease; 13. Dynamics of the dopaminergic system as a key component to the understanding of depression; 14. Physiological and therapeutic relevance of constitutive activity of 5-HT2A and 5-HT2C receptors for the treatment of depression; 15. The role of dopamine and serotonin in suicidal behaviour and aggression; ; 4. SEROTONIN-DOPAMINE INTERACTIONS IN DRUG ADDICTION; 16. Prospects for serotonin 5-HT2R pharmacotherapy in psychostimulant abuse; 17.

Pharmacological inhibition of dopamine- and serotonin activity blocks spontaneous and cocaine-activated behaviour; 18. Serotonin receptors as potential targets for modulation of nicotine use and dependence; 19. Dopamine/Serotonin releasers as medications for stimulant addictions; 20. PTEN-5-HT2C coupling: A new target for treating drug addiction; ; 5. SEROTONIN-DOPAMINE INTERACTIONS IN MOTOR DISORDERS; 21. Serotonin modulation of the basal ganglia circuitry: therapeutic implication for Parkinson's disease and other motor disorders; 22. Serotonin-Dopamine interaction in the induction and maintenance of LDOPA-induced dyskinesias; 23. Parkinson's disease -- opportunities for novel therapeutics to reduce the problems of levodopa therapy; 24. Neurobiological basis of serotonin-dopamine antagonists in the treatment of Gilles de la Tourette syndrome; ; 6. SEROTONIN-DOPAMINE INTERACTIONS IN ATTENTIONAL PROCESSES, LEARNING AND MEMORY; 25.

Serotonergic and dopaminergic modulation of attentional processes; 26. Dopamine-serotonin interactions in attention-deficit/hyperactivity disorder (ADHD); 27. Serotonin/dopamine interaction in learning; 28. Serotonin-dopamine interaction in memory formation; 29. The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking.

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