Molecular design and modeling. Volume 203 : Concepts and applications. Part B, Antibodies and antigens, nucleic acids, polysaccharides, and drugs / edited by John J. Langone.

Contributor(s): Langone, John J. (John Joseph), 1944- [editor.]
Material type: TextTextSeries: Methods in enzymology: volume 203.Publisher: San Diego : Academic Press, ©1991Description: 1 online resource (xxxi, 764 pages) : illustrations (some color)Content type: text Media type: computer Carrier type: online resourceISBN: 0121821048; 9780121821043Other title: Part B, Antibodies and antigens, nucleic acids, polysaccharides, and drugsSubject(s): Antigen-antibody reactions | Nucleic acids | Drugs -- Design | Molecules -- Models | Models, Molecular | Antibodies | Antigen-Antibody Reactions | Nucleic Acids | Polysaccharides | Drug Design | Antigen-antibody reactions | Drugs -- Design | Molecules -- Models | Nucleic acidsGenre/Form: Electronic books. Additional physical formats: Print version:: Molecular design and modeling.DDC classification: 612.012 LOC classification: QP601Online resources: Click here to access online
Contents:
Modeling of antibody combining sites / Eduardo A. Padlan, Elvin A. Kabat -- Computer modeling of combining site structure of anti-hapten monoclonal antibodies / Michael B. Bolger, Mark A. Sherman -- Protein engineering of single-chain Fv analogs and fusion proteins / James S. Huston [and others] -- Construction of single-chain Fv derivatives of monoclonal antibodies and their production in Escherichia coli / Syd Johnson, Robert E. Bird -- Humanization of monoclonal antibodies / Detlef Güssow, Gerhard Seemann -- Molecular modeling of antibody combining sites / Andrew C. R. Martin [and others] -- X-ray crystallographic analysis of free and antigen-complexed Fab fragments to investigate structural basis of immune recognition / Ian A. Wilson [and others] -- Predicting location of continuous epitopes in proteins from their primary structures / J. L. Pellequer [and others] -- Use of two-dimensional 1H nuclear magnetic resonance to study high-affinity antibody-peptide interactions / Janet C. Cheetham [and others] -- Nuclear magnetic resonance for studying peptide -- Antibody complexes by transferred nuclear overhauser effect difference spectroscopy / Jacob Anglister, Fred Naider -- Isotope-edited nuclear magnetic resonance studies of fab-peptide complexes / P. Tsang [and others] -- Reductive methylation and carbon-13 nuclear magnetic resonance in structure--function studies of Fc fragment and its subfragments / Joyce E. Jentoft -- Immunoelectron microscopy and image processing for epitope mapping / Nicolas Boisset, Jean N. Lamy -- Characterization of antigenic structures by mapping on resin-bound epitope analogs / Wan Syu, Jr., Lawrence Kahan -- Epitope mapping of allergens for rapid localization of continuous allergenic determinants / Bradley J. Walsh, Merlin E. Howden -- Design and production of bispecific monoclonal antibodies by hybrid hybridomas for use in immunoassay / Miyoko Takahashi [and others] -- Catalytic antibodies / Kevan M. Shokat, Peter G. Schultz -- Antibody catalysis of concerted, carbon---carbon bond-forming reactions / Donald Hilvert, Kenneth W. Hill -- Selection of T cell epitopes and vaccine engineering / Francesco Sinigaglia [and others].
Design, construction, and characterization of poliovirus antigen chimeras / David J. Evans, Jeffrey W. Almond -- Computer simulation of DNA supercoiling / Wilma K. Olson, Peisen Zhang -- Molecular modeling to study DNA intercalation by anti-tumor drugs / Stephen Neidle, Terence C. Jenkins -- Molecular modeling in mutagenesis and carcinogenesis / Edward L. Loechler -- In Situ hybridization and immunodetection techniques for simultaneous localization of messenger RNAs and protein epitopes in tissue sections and cultured cells / Juha Peltonen [and others] -- Transfer RNA with double identity for in Vitro kinetic modeling of transfer RNA identity in Vivo / Paul Schimmel, Jonathan J. Burbaum -- Design of simplified ribonuclease P RNA by phylogenetic comparison / Norman R. Pace, David S. Waugh -- Molecular modeling and electron diffraction of polysaccharides / Serge Pérez -- Molecular design and modeling of protein--heparin interactions / Alan D. Cardin [and others] -- Computer-assisted rational drug design / Yvonne Connolly Martin -- Pattern recognition methods in rational drug design / David J. Livingstone -- Molecular electrostatic potentials for characterizing drug-biosystem interactions / Pierre-Alain Carrupt [and others] -- Pharmacophore for nicotinic agonists / T. M. Gund, C. E. Spivak -- Related chapters published in previous volumes of Methods in Enzymology.
Summary: Computer-based design and modeling, computational approaches, and instrumental methods for elucidating molecular mechanisms of protein folding and ligand-acceptor interactions are included in Volumes 202 and 203, as are genetic and chemical methods for the production of functional molecules including antibodies and antigens, enzymes, receptors, nucleic acids and polysaccharides, and drugs.
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Called Part B in continuation of Part A issued as volume 202 of Methods in enzymology.

Includes bibliographical references and indexes.

Modeling of antibody combining sites / Eduardo A. Padlan, Elvin A. Kabat -- Computer modeling of combining site structure of anti-hapten monoclonal antibodies / Michael B. Bolger, Mark A. Sherman -- Protein engineering of single-chain Fv analogs and fusion proteins / James S. Huston [and others] -- Construction of single-chain Fv derivatives of monoclonal antibodies and their production in Escherichia coli / Syd Johnson, Robert E. Bird -- Humanization of monoclonal antibodies / Detlef Güssow, Gerhard Seemann -- Molecular modeling of antibody combining sites / Andrew C. R. Martin [and others] -- X-ray crystallographic analysis of free and antigen-complexed Fab fragments to investigate structural basis of immune recognition / Ian A. Wilson [and others] -- Predicting location of continuous epitopes in proteins from their primary structures / J. L. Pellequer [and others] -- Use of two-dimensional 1H nuclear magnetic resonance to study high-affinity antibody-peptide interactions / Janet C. Cheetham [and others] -- Nuclear magnetic resonance for studying peptide -- Antibody complexes by transferred nuclear overhauser effect difference spectroscopy / Jacob Anglister, Fred Naider -- Isotope-edited nuclear magnetic resonance studies of fab-peptide complexes / P. Tsang [and others] -- Reductive methylation and carbon-13 nuclear magnetic resonance in structure--function studies of Fc fragment and its subfragments / Joyce E. Jentoft -- Immunoelectron microscopy and image processing for epitope mapping / Nicolas Boisset, Jean N. Lamy -- Characterization of antigenic structures by mapping on resin-bound epitope analogs / Wan Syu, Jr., Lawrence Kahan -- Epitope mapping of allergens for rapid localization of continuous allergenic determinants / Bradley J. Walsh, Merlin E. Howden -- Design and production of bispecific monoclonal antibodies by hybrid hybridomas for use in immunoassay / Miyoko Takahashi [and others] -- Catalytic antibodies / Kevan M. Shokat, Peter G. Schultz -- Antibody catalysis of concerted, carbon---carbon bond-forming reactions / Donald Hilvert, Kenneth W. Hill -- Selection of T cell epitopes and vaccine engineering / Francesco Sinigaglia [and others].

Design, construction, and characterization of poliovirus antigen chimeras / David J. Evans, Jeffrey W. Almond -- Computer simulation of DNA supercoiling / Wilma K. Olson, Peisen Zhang -- Molecular modeling to study DNA intercalation by anti-tumor drugs / Stephen Neidle, Terence C. Jenkins -- Molecular modeling in mutagenesis and carcinogenesis / Edward L. Loechler -- In Situ hybridization and immunodetection techniques for simultaneous localization of messenger RNAs and protein epitopes in tissue sections and cultured cells / Juha Peltonen [and others] -- Transfer RNA with double identity for in Vitro kinetic modeling of transfer RNA identity in Vivo / Paul Schimmel, Jonathan J. Burbaum -- Design of simplified ribonuclease P RNA by phylogenetic comparison / Norman R. Pace, David S. Waugh -- Molecular modeling and electron diffraction of polysaccharides / Serge Pérez -- Molecular design and modeling of protein--heparin interactions / Alan D. Cardin [and others] -- Computer-assisted rational drug design / Yvonne Connolly Martin -- Pattern recognition methods in rational drug design / David J. Livingstone -- Molecular electrostatic potentials for characterizing drug-biosystem interactions / Pierre-Alain Carrupt [and others] -- Pharmacophore for nicotinic agonists / T. M. Gund, C. E. Spivak -- Related chapters published in previous volumes of Methods in Enzymology.

Print version record.

Computer-based design and modeling, computational approaches, and instrumental methods for elucidating molecular mechanisms of protein folding and ligand-acceptor interactions are included in Volumes 202 and 203, as are genetic and chemical methods for the production of functional molecules including antibodies and antigens, enzymes, receptors, nucleic acids and polysaccharides, and drugs.

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