Multiscale modeling of developmental systems / edited by Santiago Schnell [and others].

Contributor(s): Schnell, Santiago | Society for Developmental BiologyMaterial type: TextTextSeries: Current topics in developmental biology ; v. 81.Publication details: Amsterdam ; London : Elsevier in affiliation with Society for Developmental Biology, 2008. Description: 1 online resource (xxv, 539 pages) : illustrations (chiefly color)Content type: text Media type: computer Carrier type: online resourceSubject(s): Developmental biology -- Mathematical models | Biology -- Mathematical models | Developmental Biology | Models, Theoretical | Morphogenesis | Investigative Techniques | Biology | Growth and Development | Analytical, Diagnostic and Therapeutic Techniques and Equipment | Biological Science Disciplines | Physiological Phenomena | Natural Science Disciplines | Disciplines and Occupations | Phenomena and Processes | SCIENCE -- Life Sciences -- Developmental Biology | Biology -- Mathematical models | Developmental biology -- Mathematical models | Ontwikkelingsbiologie | Biophysics | Biology | Health & Biological SciencesGenre/Form: Electronic books. DDC classification: 571.8015118 LOC classification: QL951 | .M85 2008ebOther classification: 42.23 Online resources: Click here to access online
Contents:
Models of biological pattern formation : from elementary steps to the organization of embryonic axes / Hans Meinhardt -- Robustness of embryonic spatial patterning in Drosophila melanogaster / David Umulis, Michael B. O'Connor, and Hans G. Othmer -- Integrating morphogenesis with underlying mechanics and cell biology / Lance A. Davidson -- The mechanisms underlying primitive streak formation in the chick embryo / Manli Chuai and Cornelis J. Weijer -- Grid-free models of multicellular systems, with an application to large-scale vortices accompanying primitive streak formation / Timothy J. Newman -- Mathematical models for somite formation / Ruth E. Baker, Santiago Schnell, and Philip K. Maini -- Coordinated action of N-CAM, N-cahedrin, EphA4, end ephrinB2 translates genetic prepatterns into structure during somitogenesis in chick / James A. Glazier ... [et al.] -- Branched organs : mechanics of morphogenesis by multiple mechanisms / Sharon R. Lubkin -- Multicellular sprouting during vasculogenesis / Andras Czirok ... [et al.] -- Modeling lung branching morphogenesis / Takashi Miura -- Multiscale models for vertebrate limb development / Stuart A. Newman ... [et al.] -- Tooth morphogenesis in vivo, in vitro, and in silico / Isaac Salazar-Ciudad -- Delaunay-object-dynamics : cell mechanics with a 3D kinetic and dynamic weighted Delaunay-triangulation / Michael Meyer-Hermann -- Cellular automata as microscopic models of cell migration in heterogeneous environments / Haralambos Hatzikirou and Andreas Deutsch -- Multiscale modeling of biological pattern formation / Ramon Grima -- Relating biophysical properties across scales / Elijah Flenner ... [et al.] -- Complex multicellular systems and immune competition : new paradigms looking for a mathematical theory / Nicola Bellomo and Guido Forni.
Summary: Mathematical and computational biology is playing an increasingly important role in the biological sciences. This science brings forward unique challenges, many of which are, at the moment, beyond the theoretical techniques available. Developmental biology, due to its complexity, has lagged somewhat behind its sister disciplines (such as molecular biology and population biology) in making use of quantitative modeling to further biological understanding. This volume comprises work that is among the best developmental modeling available and we feel it will do much to remedy this situation. This book is aimed at all those with an interest in the interdisciplinary field of computer and mathematical modeling of multi-cellular and developmental systems. It is also a goal of the Editors to attract more developmental biologists to consider integrating modeling components into their research. Most importantly, this book is intended to serve as a portal into this research area for younger scientists - especially graduate students and post-docs, from both biological and quantitative backgrounds. * Articles written by leading exponents in the field * Provides techniques to address multiscale modelling * Coverage includes a wide spectrum of modeling approaches * Includes descriptions of the most recent advances in the field.
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Includes bibliographical references and index.

Print version record.

Models of biological pattern formation : from elementary steps to the organization of embryonic axes / Hans Meinhardt -- Robustness of embryonic spatial patterning in Drosophila melanogaster / David Umulis, Michael B. O'Connor, and Hans G. Othmer -- Integrating morphogenesis with underlying mechanics and cell biology / Lance A. Davidson -- The mechanisms underlying primitive streak formation in the chick embryo / Manli Chuai and Cornelis J. Weijer -- Grid-free models of multicellular systems, with an application to large-scale vortices accompanying primitive streak formation / Timothy J. Newman -- Mathematical models for somite formation / Ruth E. Baker, Santiago Schnell, and Philip K. Maini -- Coordinated action of N-CAM, N-cahedrin, EphA4, end ephrinB2 translates genetic prepatterns into structure during somitogenesis in chick / James A. Glazier ... [et al.] -- Branched organs : mechanics of morphogenesis by multiple mechanisms / Sharon R. Lubkin -- Multicellular sprouting during vasculogenesis / Andras Czirok ... [et al.] -- Modeling lung branching morphogenesis / Takashi Miura -- Multiscale models for vertebrate limb development / Stuart A. Newman ... [et al.] -- Tooth morphogenesis in vivo, in vitro, and in silico / Isaac Salazar-Ciudad -- Delaunay-object-dynamics : cell mechanics with a 3D kinetic and dynamic weighted Delaunay-triangulation / Michael Meyer-Hermann -- Cellular automata as microscopic models of cell migration in heterogeneous environments / Haralambos Hatzikirou and Andreas Deutsch -- Multiscale modeling of biological pattern formation / Ramon Grima -- Relating biophysical properties across scales / Elijah Flenner ... [et al.] -- Complex multicellular systems and immune competition : new paradigms looking for a mathematical theory / Nicola Bellomo and Guido Forni.

Mathematical and computational biology is playing an increasingly important role in the biological sciences. This science brings forward unique challenges, many of which are, at the moment, beyond the theoretical techniques available. Developmental biology, due to its complexity, has lagged somewhat behind its sister disciplines (such as molecular biology and population biology) in making use of quantitative modeling to further biological understanding. This volume comprises work that is among the best developmental modeling available and we feel it will do much to remedy this situation. This book is aimed at all those with an interest in the interdisciplinary field of computer and mathematical modeling of multi-cellular and developmental systems. It is also a goal of the Editors to attract more developmental biologists to consider integrating modeling components into their research. Most importantly, this book is intended to serve as a portal into this research area for younger scientists - especially graduate students and post-docs, from both biological and quantitative backgrounds. * Articles written by leading exponents in the field * Provides techniques to address multiscale modelling * Coverage includes a wide spectrum of modeling approaches * Includes descriptions of the most recent advances in the field.

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