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Biothermodynamics. Part C / edited by Michael L. Johnson, Jo M. Holt and Gary K. Ackers.

Contributor(s): Johnson, Michael L, 1947- | Holt, Jo M | Ackers, Gary KMaterial type: TextTextSeries: Methods in enzymology ; v. 488.Publication details: Amsterdam [Netherlands] ; Boston [Mass.] : Elsevier/Academic Press, 2011. Edition: 1st edDescription: 1 online resource (xlv, 354 pages, 8 unnumbered pages of plates) : illustrations (some color)Content type: text Media type: computer Carrier type: online resourceISBN: 9780123812681; 0123812682Subject(s): Thermodynamics | Protein binding | Protein-protein interactions | Ligands (Biochemistry) | SCIENCE -- Life Sciences -- Biochemistry | Ligands (Biochemistry) | Protein binding | Protein-protein interactions | Thermodynamics | Carrier Proteins | Hemoglobins | Ligands | ThermodynamicsGenre/Form: Electronic books. | Electronic books. Additional physical formats: Print version:: Biothermodynamics. Part C.DDC classification: 571.4 LOC classification: QP517.T48NLM classification: QU 55.9 | QU 25Online resources: Click here to access online
Contents:
1. Measurement and analysis of equilibrium binding titrations : a beginner's guide / Dorothy Beckett -- 2. Macromolecular competition titration method : accessing thermodynamics of the unmodified macromolecule-ligand interactions through spectroscopic titrations of fluorescent analogs / Wlodzimierz Bujalowksi and Maria J. Jezewska -- 3. Analysis of PKR-RNA interactions by sedimentation velocity / C. Jason Wong, Katherine Launer-Felty, and James L. Cole -- 4. Structural and thermodynamic analysis of PDZ-ligand interactions / Tyson R. Shepherd and Ernesto J. Fuentes -- 5. Thermodynamic analysis of metal ion-induced protein assembly / Andrew B. Herr and Deborah G. Conrady -- 6. Thermodynamic dissection of colicin interactions / Nicholas G. Housden and Colin Kleanthous -- 7. Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling / John E. Ladbury and Stefan T. Arold -- 8. Structural and functional energetic linkages in allosteric regulation of muscle pyruvate kinase / J. Ching Lee and Petr Herman -- 9. Analysis of free energy versus temperature curves in protein folding and macromolecular interactions / Vince J. LiCata and Chin-Chi Liu -- 10. Application of the sequential n-step kinetic mechanism to polypeptide translocases / Aaron L. Lucius, Justin M. Miller, and Burki Rajendar -- 11. A coupled equilibrium approach to study nucleosome thermodynamics / Andrew J. Andrews and Karolin Luger -- 12. Quantitative methods for measuring DNA flexibility in vitro and in vivo / Justin P. Peters, Nicole A. Becker, Emily M. Rueter, Zeljko Bajzer, Jason D. Kahn, and L. James Maher III.
Summary: The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions. Elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules.
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Includes bibliographical references and indexes.

1. Measurement and analysis of equilibrium binding titrations : a beginner's guide / Dorothy Beckett -- 2. Macromolecular competition titration method : accessing thermodynamics of the unmodified macromolecule-ligand interactions through spectroscopic titrations of fluorescent analogs / Wlodzimierz Bujalowksi and Maria J. Jezewska -- 3. Analysis of PKR-RNA interactions by sedimentation velocity / C. Jason Wong, Katherine Launer-Felty, and James L. Cole -- 4. Structural and thermodynamic analysis of PDZ-ligand interactions / Tyson R. Shepherd and Ernesto J. Fuentes -- 5. Thermodynamic analysis of metal ion-induced protein assembly / Andrew B. Herr and Deborah G. Conrady -- 6. Thermodynamic dissection of colicin interactions / Nicholas G. Housden and Colin Kleanthous -- 7. Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling / John E. Ladbury and Stefan T. Arold -- 8. Structural and functional energetic linkages in allosteric regulation of muscle pyruvate kinase / J. Ching Lee and Petr Herman -- 9. Analysis of free energy versus temperature curves in protein folding and macromolecular interactions / Vince J. LiCata and Chin-Chi Liu -- 10. Application of the sequential n-step kinetic mechanism to polypeptide translocases / Aaron L. Lucius, Justin M. Miller, and Burki Rajendar -- 11. A coupled equilibrium approach to study nucleosome thermodynamics / Andrew J. Andrews and Karolin Luger -- 12. Quantitative methods for measuring DNA flexibility in vitro and in vivo / Justin P. Peters, Nicole A. Becker, Emily M. Rueter, Zeljko Bajzer, Jason D. Kahn, and L. James Maher III.

The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions. Elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules.

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Biothermodynamics. ©2009
Biothermodynamics. ©2009
Biothermodynamics. ©2009

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