TY  - BOOK
AU  - Hoffman,Robert M.
TI  - Methionine dependence of cancer and aging: methods and protocols 
T2  - Methods in molecular biology,
SN  - 9781493987962
AV  - QP562.M4 M48 2019
U1  - 572/.65 23
PY  - 2019///]
CY  - New York, NY
PB  - Humana Press, Springer
KW  - Methionine
KW  - Cancer
KW  - Molecular aspects
KW  - Chemotherapy
KW  - Neoplasms
KW  - metabolism
KW  - Aging
KW  - fast
KW  - Laboratory Manual
KW  - Electronic books
N1  - Includes bibliographical references and index; Methods to study the role of methionine-restricted diet and methioninase in cancer growth control; Shushma Chaturvedi and Joseph R. Bertino --; Altered methionine metabolism in cancer cells; Robert M. Hoffman, Peter H. Stern, DennisW. Coalson, C. DouglasWallace, and Richard W. Erbe --; Linkage of methionine dependence and other features of malignancy; Robert M. Hoffman and Richard W. Erbe --; Isolation and characterization of methionine-independent clones from methionine-dependent cancer cells; Stacey L. Borrego, Da-Wei Lin, and Peter Kaiser --; Tumor-specific S/G2-phase cell cycle arrest of cancer cells by methionine restriction; Robert M. Hoffman and Shuya Yano --; Preclinical breast cancer models to investigate metabolic priming by methionine restriction; Elena Strekalova, Dmitry Malin, Harisha Rajanala, and Vincent L. Cryns --; Efficacy of methionine-restricted diets on cancers in vivo; Robert M. Hoffman, Yasunori Hoshiya, and Weiyan Guo --; Dietary methionine restriction-based cancer chemotherapy in rodents; Robert M. Hoffman and Peter H. Stern --; Clinical studies of methionine-restricted diets for cancer patients; Robert M. Hoffman --; Development of recombinant methioninase for cancer treatment; Robert M. Hoffman, Yuying Tan, Shukuan Li, Qinghong Han, Shigeo Yagi, Tomoaki Takakura, Akio Takimoto, Kenji Inagaki, and Daizou Kudou --; Methioninase cell-cycle trap cancer chemotherapy; Robert M. Hoffman, Shuya Yano, and Kentaro Igarashi --; High efficacy of recombinant methioninase on patient-derived orthotopic xenograft (PDOX) mouse models of cancer; Robert M. Hoffman, Takashi Murakami, Kei Kawaguchi, Kentaro Igarashi, Yuying Tan, Shukuan Li, and Qinghong Han --; Total methionine restriction treatment of cancer; Robert M. Hoffman, Demetrius M. Kokkinakis, and Eugene P. Frenkel --; Methioninase gene therapy; Robert M. Hoffman, Kenji Miki, Waddah Al-Refaie, Mingxu Xu, and Yuying Tan --; Selenomethionine and methioninase : selenium free radical anticancer activity; Julian E. Spallholz --; Safety and toxicity of recombinant methioninase and polyethylene glycol (PEG) recombinant methioninase in primates; Robert M. Hoffman, Zhijian Yang, Yuying Tan, Qinghong Han, Shukuan Li, and Shigeo Yagi --; Pilot phase I clinical trial of methioninase on high-stage cancer patients : rapid depletion of circulating methionine; Robert M. Hoffman, Yuying Tan, Shukuan Li, Qinghong Han, Jorge Zavala Sr, and Jorge Zavala Jr --; Methionine gamma lyase from Clostridium sporogenes increases the anticancer efficacy of doxorubicin on A549 cancer cells in vitro and human cancer xenografts; V.S. Pokrovsky, N. Yu. Anisimova, D. Zh. Davydov, S.V. Bazhenov, N.V. Bulushova, G.B. Zavilgelsky, V.Y. Kotova, and I.V. Manukhov --; Methionine restriction and life-span extension; Robert M. Hoffman --; L-[Methyl-11C] methionine-positron-emission tomography (MET-PET); Robert M. Hoffman --; Is the Hoffman effect for methionine overuse analogous to the warburg effect for glucose overuse in cancer?; Robert M. Hoffman --; Recombinant methioninase as a DNA demethylation agent; Robert M. Hoffman and David Machover --; Homocysteine, thioretinaco ozonide, and oxidative phosphorylation in cancer and aging : a proposed clinical trial protocol; Kilmer S. McCully --; Afterword : oral methioninase--answer to cancer and fountain of youth?; Robert M. Hoffman, Qinghong Han, Kei Kawaguchi, Shukuan Li, and Yuying Tan --; Epilogue : why do we keep mis-targeting cancer chemotherapy when the methionine target has been obvious for more than a half-century?
UR  - https://link-springer-com.libraryproxy.ist.ac.at/10.1007/978-1-4939-8796-2
ER  -