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019 _a964869748
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020 _a9781627037099
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020 _a1627037098
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020 _a162703708X
020 _a9781627037082
020 _z9781627037082
024 7 _a10.1007/978-1-62703-709-9
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082 0 4 _a572.88
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049 _aMAIN
245 0 0 _aRNA sequence, structure, and function :
_bcomputational and bioinformatic methods /
_cedited by Jan Gorodkin, Walter L. Ruzzo.
264 1 _aNew York :
_bHumana Press,
_c[2014]
264 4 _c©2014
300 _a1 online resource (xi, 533 pages) :
_billustrations (chiefly black and white)
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMethods in molecular biology,
_x1940-6029 ;
_v1097
505 0 0 _tConcepts and Introduction to RNA Bioinformatics --
_tThe Principles of RNA Structure Architecture --
_tThe Determination of RNA Folding Nearest Neighbor Parameters --
_tEnergy Directed RNA Structure Prediction --
_tIntroduction to Stochastic Context Free Grammars --
_tAn Introduction to RNA Databases --
_tEnergy-based RNA Consensus Secondary Structure Prediction in Multiple Sequence Alignments --
_tSCFGs in RNA Secondary Structure Prediction: A Hands-on Approach --
_tAnnotating Functional RNAs in Genomes using Infernal --
_tClass-specific Prediction of ncRNAs --
_tAbstract Shape Analysis of RNA --
_tIntroduction to RNA Secondary Structure Comparison --
_tRNA Structural Alignments, Part I: Sankoff Based Approaches for Structural Alignments --
_tRNA Structural Alignments, Part II: Non-Sankoff Approaches for Structural Alignments --
_tDe novo Discovery of Structured ncRNA Motifs in Genomic Sequences., -- Phylogeny and Evolution of RNA Structure --
_tThe Art of Editing RNA Structural Alignments --
_tAutomated Modeling of RNA 3D Structure --
_tComputational Prediction of RNA-RNA Interactions --
_tComputational Prediction of microRNA Genes --
_tMicroRNA Target Finding by Comparative Genomics --
_tBioinformatics of siRNA Design --
_tRNA-protein Interactions: An Overview.
504 _aIncludes bibliographical references and index.
520 _aThe existence of genes for RNA molecules not coding for proteins (ncRNAs) has been recognized since the 1950's, but until recently, aside from the critically important ribosomal and transfer RNA genes, most focus has been on protein coding genes. However, a long series of striking discoveries, from RNA's ability to carry out catalytic function, to discovery of riboswitches, microRNAs and other ribo-regulators performing critical tasks in essentially all living organisms, has created a burgeoning interest in this primordial component of the biosphere. However, the structural characteristics and evolutionary constraints on RNA molecules are very different from those of proteins, necessitating development of a completely new suite of informatic tools to address these challenges. In RNA Sequence, Structure, Function: Computational and Bioinformatic Methods, expert researchers in the field describe a substantial and relevant fraction of these methodologies from both practical and computational/algorithmic perspectives. Focusing on both of these directions addresses both the biologist interested in knowing more about RNA bioinformatics as well as the bioinformaticist interested in more detailed aspects of the algorithms. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results. Thorough and intuitive, RNA Sequence, Structure, Function: Computational and Bioinformatic Methods aids scientists in continuing to study key methods and principles of RNA bioinformatics.
588 0 _aPrint version record.
546 _aEnglish.
610 2 7 _aInstitut für Ressourcenschonende und Nachhaltige Systeme
_2gnd
_989475
650 0 _aRNA.
_979961
650 0 _aNucleotide sequence.
_919015
650 2 _aMolecular Conformation.
_986319
650 2 _aNatural Science Disciplines.
_912499
650 2 _aInvestigative Techniques
_912500
650 2 _aNucleic Acids.
_979965
650 2 _aSequence Analysis.
_918393
650 2 _aBiology.
_94937
650 2 _aGenetic Structures.
_980975
650 2 _aGenetic Techniques.
_92075
650 2 _aNucleic Acids, Nucleotides, and Nucleosides
_979966
650 2 _aAnalytical, Diagnostic and Therapeutic Techniques and Equipment
_912503
650 2 _aGenetic Phenomena.
_94405
650 2 _aBiological Science Disciplines.
_912496
650 2 _aMolecular Structure.
_913251
650 2 _aDisciplines and Occupations
_912501
650 2 _aPhenomena and Processes
_912502
650 2 _aBiochemical Phenomena.
_95597
650 2 _aChemicals and Drugs
_913222
650 2 _aChemical Phenomena.
_989476
650 2 _aNucleic Acid Conformation.
_986581
650 2 _aComputational Biology.
_989477
650 2 _aSequence Analysis, RNA.
_989478
650 2 _aRNA.
_979961
650 2 _aChemistry.
_91851
650 2 _aMethods.
_934001
650 7 _aNucleotide sequence.
_2fast
_0(OCoLC)fst01041106
_919015
650 7 _aRNA.
_2fast
_0(OCoLC)fst01086244
_979961
650 7 _aBioinformatik
_2gnd
_917085
650 7 _aMethode
_2gnd
_92960
655 4 _aAufsatzsammlung.
_92773
700 1 _aGorodkin, Jan,
_eeditor.
_989479
700 1 _aRuzzo, Walter L.,
_eeditor.
_989480
776 0 8 _iPrint version:
_tRNA sequence, structure, and function.
_dNew York : Humana Press, [2014]
_z9781627037082
_w(DLC) 2013955606
_w(OCoLC)870978448
830 0 _aMethods in molecular biology (Clifton, N.J.) ;
_vv. 1097.
_x1064-3745
_989481
856 4 0 _uhttps://link-springer-com.libraryproxy.ist.ac.at/10.1007/978-1-62703-709-9
938 _aYBP Library Services
_bYANK
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994 _a92
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999 _c391218
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